: Long-term Results of Transoral Robotic Surgery for Oropharyngeal Carcinoma

SciVee ◽  
2012 ◽  
Author(s):  
Eric J. Moore ◽  
Steven M. Olson ◽  
Rebecca R. Laborde ◽  
Joaquin J. Garcia ◽  
Francis J. Walsh ◽  
...  
Keyword(s):  
Robotic Surgery ◽  
Transoral Robotic Surgery ◽  
Long Term Results ◽  
Oropharyngeal Carcinoma

Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial

2022 ◽  
Author(s):  
Anthony C. Nichols ◽  
Julie Theurer ◽  
Eitan Prisman ◽  
Nancy Read ◽  
Eric Berthelet ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Robotic Surgery ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transoral Robotic Surgery ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Md Anderson ◽  
Anderson Dysphagia Inventory ◽  
Over Time

PURPOSE The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has risen rapidly, because of an epidemic of human papillomavirus infection. The optimal management of early-stage OPSCC with surgery or radiation continues to be a clinical controversy. Long-term randomized data comparing these paradigms are lacking. METHODS We randomly assigned patients with T1-T2, N0-2 (≤ 4 cm) OPSCC to radiotherapy (RT) (with chemotherapy if N1-2) versus transoral robotic surgery plus neck dissection (TORS + ND) (with or without adjuvant therapy). The primary end point was swallowing quality of life (QOL) at 1-year using the MD Anderson Dysphagia Inventory. Secondary end points included adverse events, other QOL outcomes, overall survival, and progression-free survival. All analyses were intention-to-treat. Herein, we present long-term outcomes from the trial. RESULTS Sixty-eight patients were randomly assigned (n = 34 per arm) between August 10, 2012, and June 9, 2017. Median follow-up was 45 months. Longitudinal MD Anderson Dysphagia Inventory analyses demonstrated statistical superiority of RT arm over time ( P = .049), although the differences beyond 1 year were of smaller magnitude than at the 1-year timepoint (year 2: 86.0 ± 13.5 in the RT arm v 84.8 ± 12.5 in the TORS + ND arm, P = .74; year 3: 88.9 ± 11.3 v 83.3 ± 13.9, P = .12). These differences did not meet the threshold to qualify as a clinically meaningful change at any timepoint. Certain differences in QOL concerns including more pain and dental concerns in the TORS + ND arm seen at 1 year resolved at 2 and 3 years; however, TORS patients started to use more nutritional supplements at 3 years ( P = .015). Dry mouth scores were higher in RT patients over time ( P = .041). CONCLUSION On longitudinal analysis, the swallowing QOL difference between primary RT and TORS + ND approaches persists but decreases over time. Patients with OPSCC should be informed about the pros and cons of both treatment options (ClinicalTrials.gov identifier: NCT01590355 ).

scholarly journals Oncologic Outcomes Following Transoral Robotic Surgery for Human Papillomavirus–Associated Oropharyngeal Carcinoma in Older Patients

2020 ◽  
Vol 146 (12) ◽  
pp. 1167
Author(s):  
Harman S. Parhar ◽  
David Shimunov ◽  
Jason G. Newman ◽  
Steven B. Cannady ◽  
Karthik Rajasekaran ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Robotic Surgery ◽  
Older Patients ◽  
Transoral Robotic Surgery ◽  
Oncologic Outcomes ◽  
Oropharyngeal Carcinoma

Muscle invasion in oropharyngeal carcinoma undergoing transoral robotic surgery

Head & Neck ◽  
2020 ◽  
Author(s):  
Robert M. McKenzie ◽  
Harman S. Parhar ◽  
Tony L. Ng ◽  
Eitan Prisman
Keyword(s):  
Robotic Surgery ◽  
Transoral Robotic Surgery ◽  
Oropharyngeal Carcinoma ◽  
Muscle Invasion

Long-term swallowing performance following transoral robotic surgery for obstructive sleep apnea

2018 ◽  
Vol 129 (2) ◽  
pp. 422-428 ◽  
Author(s):  
Miki Paker ◽  
Irit Duek ◽  
Faten Awwad ◽  
Limor Benyamini ◽  
Tsipi Meshyeev ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Robotic Surgery ◽  
Transoral Robotic Surgery ◽  
Obstructive Sleep

Transoral robotic surgery for oropharyngeal carcinoma and its impact on patient-reported quality of life and function

Head & Neck ◽  
2011 ◽  
Vol 34 (2) ◽  
pp. 146-154 ◽  
Author(s):  
Fernando Danelon Leonhardt ◽  
Harry Quon ◽  
Marcio Abrahão ◽  
Bert W. O'Malley ◽  
Gregory S. Weinstein
Keyword(s):  
Quality Of Life ◽  
Robotic Surgery ◽  
Transoral Robotic Surgery ◽  
Oropharyngeal Carcinoma ◽  
Patient Reported ◽  
And Function

scholarly journals Transoral Robotic Surgery for Advanced Oropharyngeal Carcinoma

2010 ◽  
Vol 136 (11) ◽  
pp. 1079 ◽  
Author(s):  
Gregory S. Weinstein ◽  
Bert W. O’Malley ◽  
Marc A. Cohen ◽  
Harry Quon
Keyword(s):  
Robotic Surgery ◽  
Transoral Robotic Surgery ◽  
Oropharyngeal Carcinoma
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