Homeostatic Regulation of Photoreceptor Cell Integrity: Significance of the Potent Mediator Neuroprotectin D1 Biosynthesized from Docosahexaenoic Acid (The Proctor Lecture)

SciVee ◽  
2011 ◽  
Keyword(s):  
Docosahexaenoic Acid ◽  
Photoreceptor Cell ◽  
Homeostatic Regulation ◽  
Cell Integrity ◽  
Neuroprotectin D1

scholarly journals Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Dennis S. Rice ◽  
Jorgelina M. Calandria ◽  
William C. Gordon ◽  
Bokkyoo Jun ◽  
Yongdong Zhou ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Opposite Effect ◽  
Photoreceptor Cell ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Adiponectin Receptor ◽  
Cell Integrity ◽  
Photoreceptor Degeneration ◽  
Adiponectin Receptor 1

Abstract The identification of pathways necessary for photoreceptor and retinal pigment epithelium (RPE) function is critical to uncover therapies for blindness. Here we report the discovery of adiponectin receptor 1 (AdipoR1) as a regulator of these cells’ functions. Docosahexaenoic acid (DHA) is avidly retained in photoreceptors, while mechanisms controlling DHA uptake and retention are unknown. Thus, we demonstrate that AdipoR1 ablation results in DHA reduction. In situ hybridization reveals photoreceptor and RPE cell AdipoR1 expression, blunted in AdipoR1−/− mice. We also find decreased photoreceptor-specific phosphatidylcholine containing very long-chain polyunsaturated fatty acids and severely attenuated electroretinograms. These changes precede progressive photoreceptor degeneration in AdipoR1−/− mice. RPE-rich eyecup cultures from AdipoR1−/− reveal impaired DHA uptake. AdipoR1 overexpression in RPE cells enhances DHA uptake, whereas AdipoR1 silencing has the opposite effect. These results establish AdipoR1 as a regulatory switch of DHA uptake, retention, conservation and elongation in photoreceptors and RPE, thus preserving photoreceptor cell integrity.

scholarly journals Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

2010 ◽  
Vol 51 (8) ◽  
pp. 2018-2031 ◽  
Author(s):  
Nicolas G. Bazan ◽  
Jorgelina M. Calandria ◽  
Charles N. Serhan
Keyword(s):  
Docosahexaenoic Acid ◽  
Photoreceptor Cell ◽  
Cell Renewal ◽  
Neuroprotectin D1

scholarly journals Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e15816 ◽  
Author(s):  
Yuhai Zhao ◽  
Frederic Calon ◽  
Carl Julien ◽  
Jeremy W. Winkler ◽  
Nicos A. Petasis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Docosahexaenoic Acid ◽  
Neuronal Survival ◽  
Disease Models ◽  
Neuroprotectin D1

Essentiality of docosahexaenoic acid in retina photoreceptor cell development

Lipids ◽  
1999 ◽  
Vol 34 (S1) ◽  
pp. S115-S115 ◽  
Author(s):  
N. P. Rotstein ◽  
M. I. Aveldaño ◽  
L. E. Politi
Keyword(s):  
Docosahexaenoic Acid ◽  
Photoreceptor Cell ◽  
Cell Development

P2-396: Docosahexaenoic acid and neuroprotectin D1 signaling in Alzheimer's disease brain and in Alzheimer models

2008 ◽  
Vol 4 ◽  
pp. T489-T489
Author(s):  
Walter J. Lukiw ◽  
Yuhai Zhao ◽  
Jian-Guo Cui ◽  
Nicolas G. Bazan ◽  
Pranab K. Mukherjee
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Docosahexaenoic Acid ◽  
Neuroprotectin D1
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