Role of the Neural Crest in Vertebrate Development and Evolution - Part 2: The Role of the Neural Crest in Head Development and in Vertebrate Evolution (30:04)

SciVee ◽  
2009 ◽  
Development ◽  
2021 ◽  
Vol 148 (4) ◽  
pp. dev196030
Author(s):  
Natalie J. Milmoe ◽  
Abigail S. Tucker

ABSTRACTWithin the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues of the head. In the eye and ear, these neural crest cells then transform back into an epithelium, via mesenchymal-to-epithelial transition (MET), highlighting the flexibility of this population. Elsewhere in the head, the epithelium loses its integrity and transforms into mesenchyme. Here, we review these craniofacial transitions, looking at why they happen, the factors that trigger them, and the cell and molecular changes they involve. We also discuss the consequences of aberrant EMT and MET in the head.


2021 ◽  
pp. 105971232110306
Author(s):  
Vincenzo Raimondi

Genetic reductionism is increasingly seen as a severely limited approach to understanding living systems. The Neo-Darwinian explanatory framework tends to overlook the role of the organism for an understanding of development and evolution. In the current fast-changing theoretical landscape, the autopoietic approach provides conceptual distinctions and tools that may contribute to building an alternative framework. In this article, I examine the implications of the theories of autopoiesis and natural drift for an organism-centered view of evolution. By shifting the attention from genes to ontogenetic organism-niche configurations and their transformations over generations, this approach presents a compelling perspective on the role of organismal behavior in guiding phylogenetic drift.


2006 ◽  
Vol 235 (10) ◽  
pp. 2722-2735 ◽  
Author(s):  
Binnur Eroglu ◽  
Guanghu Wang ◽  
Naxin Tu ◽  
Xutong Sun ◽  
Nahid F. Mivechi

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