Orientia tsutsugamushi Infection Induces CD4+ T Cell Activation via Human Dendritic Cell Activity

2013 ◽  
Vol 23 (8) ◽  
pp. 1159-1166 ◽  
Author(s):  
Hyuk Chu
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cell Activity ◽  
Cd4 T Cell ◽  
Human Dendritic Cell ◽  
Orientia Tsutsugamushi

Functionalized Polystyrene Nanoparticles Trigger Human Dendritic Cell Maturation Resulting in Enhanced CD4+T Cell Activation

2012 ◽  
Vol 12 (12) ◽  
pp. 1637-1647 ◽  
Author(s):  
Stefanie U. Frick ◽  
Nicole Bacher ◽  
Grit Baier ◽  
Volker Mailänder ◽  
Katharina Landfester ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Dendritic Cell Maturation ◽  
Cd4 T Cell ◽  
Cell Maturation ◽  
Human Dendritic Cell ◽  
Polystyrene Nanoparticles

Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4 + T‐cell activation and dendritic cell maturation

2016 ◽  
Vol 94 (7) ◽  
pp. 689-700 ◽  
Author(s):  
Harold Oliva ◽  
Rodrigo Pacheco ◽  
José M Martinez‐Navio ◽  
Marta Rodríguez‐García ◽  
Mar Naranjo‐Gómez ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cytidine Deaminase ◽  
Subcellular Location ◽  
Dendritic Cell Maturation ◽  
Cd4 T Cell ◽  
Cell Maturation

scholarly journals Nanoparticle-Mediated Combinatorial Targeting of Multiple Human Dendritic Cell (DC) Subsets Leads to Enhanced T Cell Activation via IL-15–Dependent DC Crosstalk

2014 ◽  
Vol 193 (5) ◽  
pp. 2297-2305 ◽  
Author(s):  
Kartik Sehgal ◽  
Ragy Ragheb ◽  
Tarek M. Fahmy ◽  
Madhav V. Dhodapkar ◽  
Kavita M. Dhodapkar
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Dendritic Cell

scholarly journals Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse

2018 ◽  
Vol 3 ◽  
pp. 84 ◽  
Author(s):  
Chiara Beilin ◽  
Kaushik Choudhuri ◽  
Gerben Bouma ◽  
Dessislava Malinova ◽  
Jaime Llodra ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Immunological Synapse ◽  
Nk Cell ◽  
Severe Combined Immunodeficiency ◽  
Cd4 T Cell ◽  
Gamma Chain

Background:Mutations of the common cytokine receptor gamma chain (γc) cause Severe Combined Immunodeficiency characterized by absent T and NK cell development. Although stem cell therapy restores these lineages, residual immune defects are observed that may result from selective persistence of γc-deficiency in myeloid lineages. However, little is known about the contribution of myeloid-expressed γc to protective immune responses.  Here we examine the importance of γc for myeloid dendritic cell (DC) function.Methods:We utilize a combination ofin vitroDC/T-cell co-culture assays and a novel lipid bilayer system mimicking the T cell surface to delineate the role of DC-expressed γc during DC/T-cell interaction.Results:We observed that γc in DC was recruited to the contact interface following MHCII ligation, and promoted IL-15Rα colocalization with engaged MHCII. Unexpectedly, trans-presentation of IL-15 was required for optimal CD4+T cell activation by DC and depended on DC γc expression. Neither recruitment of IL-15Rα nor IL-15 trans-signaling at the DC immune synapse (IS), required γc signaling in DC, suggesting that γc facilitates IL-15 transpresentation through induced intermolecularcisassociations or cytoskeletal reorganization following MHCII ligation.Conclusions:These findings show that DC-expressed γc is required for effective antigen-induced CD4+ T cell activation. We reveal a novel mechanism for recruitment of DC IL-15/IL-15Rα complexes to the IS, leading to CD4+ T cell costimulation through localized IL-15 transpresentation that is coordinated with antigen-recognition.

scholarly journals Multistage T Cell–Dendritic Cell Interactions Control Optimal CD4 T Cell Activation through the ADAP-SKAP55–Signaling Module

2013 ◽  
Vol 191 (5) ◽  
pp. 2372-2383 ◽  
Author(s):  
Jason S. Mitchell ◽  
Brandon J. Burbach ◽  
Rupa Srivastava ◽  
Brian T. Fife ◽  
Yoji Shimizu
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cell Interactions ◽  
Cd4 T Cell

HIV-1 Nef Induces Dendritic Cell Differentiation: A Possible Mechanism of Uninfected CD4+ T Cell Activation

2002 ◽  
Vol 275 (2) ◽  
pp. 243-254 ◽  
Author(s):  
Maria Giovanna Quaranta ◽  
Elena Tritarelli ◽  
Luciana Giordani ◽  
Marina Viora
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd4 T Cell ◽  
Dendritic Cell Differentiation ◽  
Hiv 1

scholarly journals Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse

2018 ◽  
Vol 3 ◽  
pp. 84 ◽  
Author(s):  
Chiara Beilin ◽  
Kaushik Choudhuri ◽  
Gerben Bouma ◽  
Dessislava Malinova ◽  
Jaime Llodra ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Immunological Synapse ◽  
Nk Cell ◽  
Severe Combined Immunodeficiency ◽  
Cd4 T Cell ◽  
Gamma Chain

Background:Mutations of the common cytokine receptor gamma chain (γc) cause Severe Combined Immunodeficiency characterized by absent T and NK cell development. Although stem cell therapy restores these lineages, residual immune defects are observed that may result from selective persistence of γc-deficiency in myeloid lineages. However, little is known about the contribution of myeloid-expressed γc to protective immune responses.  Here we examine the importance of γc for myeloid dendritic cell (DC) function.Methods:We utilize a combination ofin vitroDC/T-cell co-culture assays and a novel lipid bilayer system mimicking the T cell surface to delineate the role of DC-expressed γc during DC/T-cell interaction.Results:We observed that γc in DC was recruited to the contact interface following MHCII ligation, and promoted IL-15Rα colocalization with engaged MHCII. Unexpectedly, trans-presentation of IL-15 was required for optimal CD4+T cell activation by DC and depended on DC γc expression. Neither recruitment of IL-15Rα nor IL-15 trans-signaling at the DC immune synapse (IS), required γc signaling in DC, suggesting that γc facilitates IL-15 transpresentation through induced intermolecularcisassociations or cytoskeletal reorganization following MHCII ligation.Conclusions:These findings show that DC-expressed γc is required for effective antigen-induced CD4+ T cell activation. We reveal a novel mechanism for recruitment of DC IL-15/IL-15Rα complexes to the IS, leading to CD4+ T cell costimulation through localized IL-15 transpresentation that is coordinated with antigen-recognition.

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