High Molecular Weight Poly-Gamma-Glutamic Acid Regulates Lipid Metabolism in Rats Fed a High-Fat Diet and Humans

2011 ◽  
Vol 21 (7) ◽  
pp. 766-775 ◽  
Author(s):  
Ji Ho Park
Keyword(s):  
Molecular Weight ◽  
Lipid Metabolism ◽  
Glutamic Acid ◽  
High Molecular Weight ◽  
High Fat Diet ◽  
High Fat ◽  
High Molecular Weight Poly

Persimmon Tannin accounts for hypolipidemic effects of persimmon through activating of AMPK and suppressing NF-κB activation and inflammatory responses in High-Fat Diet Rats

2014 ◽  
Vol 5 (7) ◽  
pp. 1536-1546 ◽  
Author(s):  
Bo Zou ◽  
Zhen-zhen Ge ◽  
Ying Zhang ◽  
Jing Du ◽  
Ze Xu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
High Fat Diet ◽  
Inflammatory Responses ◽  
Central Component ◽  
High Fat ◽  
Ampk Pathway

High molecular weight persimmon tannin is a central component accounting for the anti-hyperlipidemic effects of consuming persimmon fruits via AMPK pathway.

scholarly journals Synthesis of controlled, high-molecular weight poly(l-glutamic acid) brush polymers

2017 ◽  
Vol 5 (9) ◽  
pp. 1836-1844 ◽  
Author(s):  
Ryan Baumgartner ◽  
Diane Kuai ◽  
Jianjun Cheng
Keyword(s):  
Molecular Weight ◽  
Glutamic Acid ◽  
High Molecular Weight ◽  
Synthesis And Characterization ◽  
High Molecular Weight Poly ◽  
Brush Polymers

We report the synthesis and characterization of high-molecular weight poly(l-glutamic acid) based brush polymers.

scholarly journals Functional Comparison of High and Low Molecular Weight Chitosan on Lipid Metabolism and Signals in High-Fat Diet-Fed Rats

2018 ◽  
Author(s):  
Shing-Hwa Liu ◽  
Chen-Yuan Chiu ◽  
Ching-Ming Shi ◽  
Meng-Tsan Chiang
Keyword(s):  
Molecular Weight ◽  
Lipid Metabolism ◽  
Protein Expression ◽  
High Fat Diet ◽  
Liver Lipid ◽  
Lipid Absorption ◽  
Low Molecular Weight ◽  
High Fat ◽  
Apo E ◽  
Protein Expressions

The present study examined and compared the effects of high- and low-molecular weight (MW) chitosan, a nutraceutical, on intestinal and liver lipid metabolism in rats fed with high-fat diet. Both high- and low-MW chitosan decreased liver weight, elongated small intestine, improved the dysregulation of blood lipids and liver fat accumulation, and increased fecal lipid excretion in high-fat diet-fed rats. Supplementation of both high- and low-MW chitosan significantly inhibited the decreased phosphorylated AMP-activated protein kinase (AMPK)α and peroxisome proliferator-activated receptor (PPAR)α protein expressions and the increased lipogenesis/cholesterogenesis-associated protein expressions (sterol regulatory element binding protein (SREBP)1c, SREBP2, and PPARγ) and the decreased apolipoprotein (Apo)E and microsomal triglyceride transfer protein (MTTP) protein expressions in the livers of high-fat diet-fed rats. Both high and low-MW chitosan supplementation could also suppress the increased MTTP protein expression and the decreased angiopoietin-like protein (Angptl)4 protein expression in the intestines of high-fat diet-fed rats. Comparison between high and low-MW chitosan, high-MW chitosan has a higher efficiency than low-MW chitosan on the inhibition of intestinal lipid absorption and the increase of hepatic fatty acid oxidation, which can improve liver lipid biosynthesis and accumulation.

Synthesis of super-high-molecular-weight poly-γ-glutamic acid by Bacillus subtilis subsp. chungkookjang

2005 ◽  
Vol 35 (4-6) ◽  
pp. 128-133 ◽  
Author(s):  
Chung Park ◽  
Jae-Chul Choi ◽  
Yoon-Ho Choi ◽  
Hisaaki Nakamura ◽  
Kazuya Shimanouchi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Bacillus Subtilis ◽  
Glutamic Acid ◽  
High Molecular Weight ◽  
Subtilis Subsp ◽  
High Molecular Weight Poly
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