scholarly journals Radiation Effects of Carbon Ions and Gamma Ray on UDMA Based Dental Resin.

2001 ◽  
Vol 20 (4) ◽  
pp. 325-338 ◽  
Author(s):  
Sejuty HAQUE ◽  
Shuichi TAKINAMI ◽  
Fumio WATARI ◽  
Mahfujul Haq KHAN ◽  
Motoyasu NAKAMURA
Keyword(s):  
Radiation Effects ◽  
Gamma Ray ◽  
Carbon Ions ◽  
Dental Resin

Ionized Radiation-Mediated Retinoid Oxidation in the Retina and Retinal Pigment Epithelium of the Murine Eye

2021 ◽  
Author(s):  
Marina A. Yakovleva ◽  
Tatiana B. Feldman ◽  
Kristina N. Lyakhova ◽  
Dina M. Utina ◽  
Inna A. Kolesnikova ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Radiation Effects ◽  
Gamma Ray ◽  
Degradation Products ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Mouse Retina ◽  
Fluorescent Properties

The present study evaluated the effects of proton and gamma-ray ionizing radiation on the mouse eye. The aim of this work was to analyze radiation-mediated retinoid oxidation in the retina and retinal pigment epithelium (RPE). The findings from this analysis can be used to develop a noninvasive method for rapid assessment of the effects of ionizing radiation. Comparative fluorescence and chromatographic analyses of retinoids before and after irradiations were performed. The fluorescent properties of chloroform extracts from irradiated mouse retina and RPE exhibited an increase in fluorescence intensity in the short-wave region of the spectrum (λ < 550 nm). This change is due to increased retinal and RPE retinoid oxidation and degradation products after radiation exposure. Comparative analyses of radiation effects demonstrated that the effect of proton exposure on the retina and RPE was higher than that of gamma-ray exposure. The present study revealed a new approach to assessing the level of radiation exposure in ocular tissues.

Gamma-ray radiation effects in graphene-based transistors with h-BN nanometer film substrates

2019 ◽  
Vol 115 (22) ◽  
pp. 223504 ◽  
Author(s):  
E. Cazalas ◽  
M. R. Hogsed ◽  
S. Vangala ◽  
M. R. Snure ◽  
J. W. McClory
Keyword(s):  
Radiation Effects ◽  
Gamma Ray

scholarly journals Radiation effects in CdZnTe gamma-ray detectors produced by 199-MeV protons

1996 ◽  
Author(s):  
Larry S. Varnell ◽  
William A. Mahoney ◽  
Ethan L. Hull ◽  
Jack F. Butler ◽  
Ahsan Wong
Keyword(s):  
Radiation Effects ◽  
Gamma Ray ◽  
Gamma Ray Detectors ◽  
Mev Protons

Gamma-ray and fast neutron radiation effects on thin film superconductors

1994 ◽  
Vol 41 (6) ◽  
pp. 2521-2524 ◽  
Author(s):  
J.A. Cooksey ◽  
W.D. Brown ◽  
S.S. Ang ◽  
H.A. Naseem ◽  
R.K. Ulrich ◽  
...  
Keyword(s):  
Thin Film ◽  
Fast Neutron ◽  
Radiation Effects ◽  
Gamma Ray ◽  
Neutron Radiation ◽  
Neutron Radiation Effects

scholarly journals Evaluation of Histone Deacetylase Inhibitors as Radiosensitizers for Proton and Light Ion Radiotherapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Alicia M. Johnson ◽  
Paula V. Bennett ◽  
Katherine Z. Sanidad ◽  
Anthony Hoang ◽  
James H. Jardine ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Gamma Ray ◽  
Ion Irradiation ◽  
Clinical Effectiveness ◽  
Clonogenic Survival ◽  
Low Doses ◽  
Carbon Ions

Significant opportunities remain for pharmacologically enhancing the clinical effectiveness of proton and carbon ion-based radiotherapies to achieve both tumor cell radiosensitization and normal tissue radioprotection. We investigated whether pretreatment with the hydroxamate-based histone deacetylase inhibitors (HDACi) SAHA (vorinostat), M344, and PTACH impacts radiation-induced DNA double-strand break (DSB) induction and repair, cell killing, and transformation (acquisition of anchorage-independent growth in soft agar) in human normal and tumor cell lines following gamma ray and light ion irradiation. Treatment of normal NFF28 primary fibroblasts and U2OS osteosarcoma, A549 lung carcinoma, and U87MG glioma cells with 5–10 µM HDACi concentrations 18 h prior to cesium-137 gamma irradiation resulted in radiosensitization measured by clonogenic survival assays and increased levels of colocalized gamma-H2AX/53BP1 foci induction. We similarly tested these HDACi following irradiation with 200 MeV protons, 290 MeV/n carbon ions, and 350 MeV/n oxygen ions delivered in the Bragg plateau region. Unlike uniform gamma ray radiosensitization, effects of HDACi pretreatment were unexpectedly cell type and ion species-dependent with C-12 and O-16 ion irradiations showing enhanced G0/G1-phase fibroblast survival (radioprotection) and in some cases reduced or absent tumor cell radiosensitization. DSB-associated foci levels were similar for proton-irradiated DMSO control and SAHA-treated fibroblast cultures, while lower levels of induced foci were observed in SAHA-pretreated C-12 ion-irradiated fibroblasts. Fibroblast transformation frequencies measured for all radiation types were generally LET-dependent and lowest following proton irradiation; however, both gamma and proton exposures showed hyperlinear transformation induction at low doses (≤25 cGy). HDACi pretreatments led to overall lower transformation frequencies at low doses for all radiation types except O-16 ions but generally led to higher transformation frequencies at higher doses (>50 cGy). The results of these in vitro studies cast doubt on the clinical efficacy of using HDACi as radiosensitizers for light ion-based hadron radiotherapy given the mixed results on their radiosensitization effectiveness and related possibility of increased second cancer induction.

The gamma ray radiation effects in high-electron-mobility transistors

1995 ◽  
Vol 10 (11) ◽  
pp. 1445-1451 ◽  
Author(s):  
N Arpatzanis ◽  
M Papastamatiou ◽  
G J Papaioannou ◽  
Z Hatzopoulos ◽  
G Konstandinides
Keyword(s):  
Electron Mobility ◽  
Radiation Effects ◽  
Gamma Ray ◽  
High Electron Mobility Transistors ◽  
High Electron ◽  
High Electron Mobility ◽  
Electron Mobility Transistors

scholarly journals Synchrotron FTIR Microspectroscopy Investigations on Biochemical Changes Occurring in Human Cells Exposed to Proton Beams

2021 ◽  
Vol 12 (1) ◽  
pp. 336
Author(s):  
Ines Delfino ◽  
Valerio Ricciardi ◽  
Maria Lepore
Keyword(s):  
Radiation Effects ◽  
Human Cells ◽  
Biochemical Changes ◽  
Carbon Ions ◽  
Cancer Treatments ◽  
Heavy Particles ◽  
Proton Beams ◽  
Hadron Therapy ◽  
Particle Irradiation ◽  
Cell Components

Fourier transform infrared microspectroscopy using a synchrotron radiation source (SR-μFTIR) has great potential in the study of the ionizing radiation effects of human cells by analyzing the biochemical changes occurring in cell components. SR-μFTIR spectroscopy has been usefully employed in recent years in some seminal work devoted to shedding light on processes occurring in cells treated by hadron therapy, that is, radiotherapy with charged heavy particles (mainly protons and carbon ions), which is gaining popularity as a cancer treatment modality. These studies are particularly useful for increasing the effectiveness of radiotherapy cancer treatments with charged particles that can offer significant progress in the treatment of deep-seated and/or radioresistant tumors. In this paper, we present a concise revision of these studies together with the basic principles of μFTIR spectroscopy and a brief presentation of the main characteristics of infrared SR sources. From the analysis of the literature regarding the SR-μFTIR spectroscopy investigation on human cells exposed to proton beams, it is clearly shown that changes in DNA, protein, and lipid cell components are evident. In addition, this review points out that the potential offered by SR-μFTIR in investigating the effects induced by charged particle irradiation have not been completely explored. This is a crucial point for the continued improvement of hadron therapy strategies.

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