scholarly journals Evaluation of Cytotoxicity of Calcium Phosphate Cement Consisting of .ALPHA.-Tricalcium Phosphate and Dicalcium Phosphate Dihydrate.

1998 ◽  
Vol 17 (3) ◽  
pp. 186-194 ◽  
Author(s):  
Sen HIGASHI ◽  
Tomoko OHSUMI ◽  
Keiko OZUMI ◽  
Kayoko KUROKI ◽  
Yuri INOKUCHI ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate

Preparation of Calcium Phosphate Cement Utilizing Dicalcium Phosphate Dihydrate and Calcium Carbonate

2014 ◽  
Vol 608 ◽  
pp. 280-286
Author(s):  
Nudthakarn Kosachan ◽  
Angkhana Jaroenworaluck ◽  
Sirithan Jiemsirilers ◽  
Supatra Jinawath ◽  
Ron Stevens
Keyword(s):  
Calcium Carbonate ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Raw Materials ◽  
Setting Time ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Cement Pastes ◽  
Setting Times ◽  
Phosphate Dihydrate

Calcium phosphate cement has been widely used as a bone substitute because of its chemical similarity to natural bone. In this study, calcium phosphate cement was prepared using dicalcium phosphate dihydrate (CaHPO4.2H2O) and calcium carbonate (CaCO3) as starting raw materials. The cement pastes were mixed and the chemistry adjusted with two different aqueous solutions of sodium hydroxide (NaOH) and disodium hydrogen phosphate (Na2HPO4). Concentrations of the solution were varied in the range 0.5 to 5.0 mol/L with the ratio of solid/liquid = 2 g/ml. The cement paste was then poured into a silicone mold having a diameter of 10 mm and a height 15 mm. Setting times for the cement were measured using a Vicat apparatus. XRD, FT-IR, and SEM techniques were used to characterize properties and microstructure of the cement. From the experimental results, it is clear that different concentrations of Na2HPO4 and NaOH have affected the setting times of the cement. The relationship between concentration of NaOH and Na2HPO4 and setting time, including final properties of the cement, is discussed.

Fully-Interconnected Pore Forming Calcium Phosphate Cement

2011 ◽  
Vol 493-494 ◽  
pp. 832-835 ◽  
Author(s):  
Ishikawa Kunio ◽  
Kanji Tsuru ◽  
Trung Kien Pham ◽  
Michito Maruta ◽  
Shigeki Matsuya
Keyword(s):  
Calcium Phosphate ◽  
Porous Structure ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Porous Body ◽  
Phosphate Solution ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate ◽  
Bone Defect Reconstruction ◽  
Interconnected Pore

Calcium phosphate cement that foams fully-interconnected porous structure along with its gradual replacement to bone may be ideal for bone defect reconstruction. In the present study, α-tricalcium phosphate (αTCP) microspheres were exposed to acidic calcium phosphate solution. It was found that the αTCP microspheres set in approximately 10 min to form fully-interconnected porous structure. The porosity was approximately 50% and the pore size was 300µm. The surface of the porous body was dicalcium phosphate dihydrate whereas the inside was αTCP.

Effect of Different Granular Size on the Properties of Porous β-Tricalcium Phosphate Foam Granular Cements

2019 ◽  
Vol 829 ◽  
pp. 23-27 ◽  
Author(s):  
Haifaa' Auni Mohammad Zaki ◽  
Khairul Anuar Shariff ◽  
Mohamad Hafizi Abu Bakar ◽  
Mohamad Nurul Azmi
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Reaction Times ◽  
Range Size ◽  
Dicalcium Phosphate ◽  
Morphological Observation ◽  
Phosphate Solution ◽  
Dicalcium Phosphate Dihydrate ◽  
Setting Reaction ◽  
Phosphate Dihydrate

Porous β-tricalcium phosphate (β-TCP) foam granular cements was obtained by exposing different range size of β-TCP foam granular (300-600 μm and 600-1000 μm) with 1.4 mol/L of saturated acidic calcium phosphate solution at various setting reaction times. It was found that large amount of dicalcium phosphate dihydrate (DCPD) was formed in the set specimens after exposing small size of β-TCP foam granular with saturated acidic calcium phosphate solution. Morphological observation shows that the bridging of DCPD platelet-like crystals between β-TCP foam granular surfaces were detected as early as 10 mins after exposing 300-600 μm of β-TCP foam granules with saturated acidic calcium phosphate solution. In fact, the amount of DCPD formed in the specimens obtained from small size of β-TCP foam granules is higher than large sized foam granules. These results demonstrated that small size of β-TCP foam granules induced fast setting reaction of β-TCP foam granules to produce porous β-TCP foam granular cements.

Seeded Growth of Calcium Phosphates: Effect of Different Calcium Phosphate Seed Material

1976 ◽  
Vol 55 (4) ◽  
pp. 617-624 ◽  
Author(s):  
G.H. Nancollas ◽  
J.S. Wefel
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Calcium Phosphates ◽  
Octacalcium Phosphate ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Seeded Growth ◽  
Seed Crystals ◽  
Phosphate Dihydrate ◽  
Supersaturated Solutions

The growth of calcium phosphates on seed materials, dicalcium PhosPhate dihydrate (DCPD), tricalcium phosphate (TCP), octacalcium phosphate (OCP), and hydroxyapatite (HAP) in stable supersaturated solutions has been studied under conditions of pH and concentration for which the predominant phases are 1, DCPD, and II, HAP. All seed crystals are good nucleators for DCPD in system I, but, aside from HAP itself, only OCP will readily induce growth under condition II.

Analysis on the Setting of Brushite Bone Cement after Storage in the Humid Environment

2016 ◽  
Vol 696 ◽  
pp. 32-35
Author(s):  
Tai Joo Chung ◽  
Kyung Sik Oh
Keyword(s):  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Driving Force ◽  
Activation Barrier ◽  
Setting Time ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Major Phase ◽  
Phosphate Dihydrate ◽  
Humid Environment

The cause of the degradation was analyzed by applying the highly humid conditions during the storage of cement composed of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM). For the β-TCP and MCPM stored separately under the humid environment, the mild increase in the setting time was observed, and the product after the setting was entirely dicalcium phosphate dihydrate (CaHPO42H2O: DCPD). However, for the β-TCP and MCPM stored mixed under the same condition, the setting time significantly increased with the period of storage, and the product contained dicalcium phosphate (CaHPO4: DCP) as major phase, resulting in the loss of setting ability. The formation of DCP could be because of the weak driving force for setting, caused by a feeble supply of water from moisture. As the formation of DCPD requires stronger driving force to overcome the activation barrier, sufficient amount of water is essential. Humid environment during the storage decreased the driving force by the formation of DCP, and the driving force to produce DCPD was lost during the actual setting.

Study on Hydroxyapatite Fibers with Strontium Reinforced Calcium Phosphate Cement

2013 ◽  
Vol 788 ◽  
pp. 119-126 ◽  
Author(s):  
Bin Chu ◽  
Jian Xiong ◽  
Ming Bo Wang ◽  
Xiao Li Li ◽  
Zhen Ding She
Keyword(s):  
Mechanical Property ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Solidification Time ◽  
Cytotoxicity Test ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate ◽  
Main Components ◽  
Sem Morphology

The solidification time of injectable bone cement should be fit for the clinical application. This research find out the effect of the amount of water-absorbent agent and water-retaining agent. The optimal ratio was be determined. The hydroxyapatite fibers with strontium were added into the CPC. The mechanical property, cytotoxicity test, SEM morphology, XRD and degradation performance in vitro were characterized, respectively. The results show the CPC had the solidification time of 12min when the ratio as below: β-TCP 55.5%, Ca (H2PO4)2H2O(MCPM)36%, MgHPO43H2O 5%, MgSO41%, Sodium pyrophosphate2.5%. The main components of solidify CPC were hydroxyapatite (HA) and dicalcium phosphate dihydrate (DCPD). The materials had a good Anti-collapsing performance and the degradation rate up to 16.72% after 9 weeks. The mechanical property of composite materials which combined with hydroxyapatite fibers with strontium has been improved, and the cell proliferation rate is also higher than common CPC. This study shows a potentially effective method to improve the mechanical property and the biological activity of calcium phosphate cement.

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