scholarly journals Successful treatment of acute lung injury with high-dose methylprednisolone therapy: a case report

2004 ◽  
Vol 37 (2) ◽  
pp. 157-162
Author(s):  
Hiroyuki Terawaki ◽  
Kazunobu Yoshimura ◽  
Toshio Hasegawa ◽  
Masaaki Nakayama ◽  
Tatsuo Hosoya
Keyword(s):  
Acute Lung Injury ◽  
Case Report ◽  
Lung Injury ◽  
Successful Treatment ◽  
High Dose ◽  
High Dose Methylprednisolone

scholarly journals Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Ahmed Alsolami ◽  
Kevin Shiley
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Successful Treatment ◽  
Clinical Presentation ◽  
Healthy Adult ◽  
Influenza Infection ◽  
Therapeutic Benefit ◽  
High Dose ◽  
High Dose Methylprednisolone ◽  
Acute Necrotizing

Abstract A case of influenza-associated acute necrotizing encephalitis (ANE) is described in an otherwise healthy adult. The patient was treated successfully with a combination of high-dose methylprednisolone and high-dose oseltamivir. The patient relapsed after discontinuing 150 mg twice daily oseltamivir but quickly improved and eventually recovered after reinitiation of high-dose oseltamivir for an additional 2 weeks. The clinical presentation, pathogenesis, and treatment of influenza-associated ANE is reviewed. The use of high-dose oseltamivir in combination with methylprednisolone may offer additional therapeutic benefit for this rare and poorly understood complication of influenza infection.

The harmful effect of prolonged high-dose methylprednisolone in acute lung injury

2013 ◽  
Vol 15 (2) ◽  
pp. 223-226 ◽  
Author(s):  
Da Teng ◽  
Qing-feng Pang ◽  
Wen-jin Yan ◽  
Wing Zhao Xin ◽  
Chuan-yi Xu
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Harmful Effect ◽  
High Dose ◽  
High Dose Methylprednisolone

Improved Cerebral Oxygenation After High-Dose Inhaled Aerosolized Prostacyclin Therapy for Acute Lung Injury: A Case Report

2007 ◽  
Vol 63 (5) ◽  
pp. 1155-1158 ◽  
Author(s):  
Michael F. Stiefel ◽  
Kareem A. Zaghloul ◽  
Stephanie Bloom ◽  
Vicente H. Gracias ◽  
Peter D. LeRoux
Keyword(s):  
Acute Lung Injury ◽  
Case Report ◽  
Lung Injury ◽  
Cerebral Oxygenation ◽  
High Dose

scholarly journals GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival in murine hypoxic acute lung injury

2018 ◽  
Vol 124 (4) ◽  
pp. 899-905 ◽  
Author(s):  
Nathan D. Putz ◽  
Ciara M. Shaver ◽  
Kobina Dufu ◽  
Chien-Ming Li ◽  
Qing Xu ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Oxygen Affinity ◽  
High Dose ◽  
Novel Therapy ◽  
Oxygen Affinity Of Hemoglobin

Acute respiratory distress syndrome (ARDS) is characterized by lung inflammation and pulmonary edema, leading to arterial hypoxemia and death if the hypoxemia is severe. Strategies to correct hypoxemia have the potential to improve clinical outcomes in ARDS. The goal of this study was to evaluate the potential of hemoglobin modification as a novel therapy for ARDS-induced hypoxemia. The therapeutic effect of two different doses of GBT1118, a compound that increases the oxygen affinity of hemoglobin, was evaluated in a murine model of acute lung injury induced by intratracheal LPS instillation 24 h before exposure to 5% or 10% hypoxia ( n = 8–15 per group). As expected, administration of GBT1118 to mice significantly increased the oxygen affinity of hemoglobin. Compared with mice receiving vehicle control, mice treated with GBT1118 had significantly lower mortality after LPS + 5% hypoxia (47% with vehicle vs. 22% with low-dose GBT1118, 13% with high-dose GBT1118, P = 0.032 by log rank) and had reduced severity of illness. Mice treated with GBT1118 showed a sustained significant increase in SpO2 over 4 h of hypoxia exposure. Treatment with GBT1118 did not alter alveolar-capillary permeability, bronchoalveolar lavage (BAL) inflammatory cell counts, or BAL concentrations of IL-1β, TNF-α, or macrophage inflammatory protein-1α. High-dose GBT1118 did not affect histological lung injury but did decrease tissue hypoxia as measured intensity of pimonidazole (Hypoxyprobe) staining in liver ( P = 0.043) and kidney ( P = 0.043). We concluded that increasing the oxygen affinity of hemoglobin using GBT1118 may be a novel therapy for treating hypoxemia associated with acute lung injury. NEW & NOTEWORTHY In this study, we show that GBT1118, a compound that increases hemoglobin affinity for oxygen, improves survival and oxygen saturation in a two-hit lung injury model of intratracheal LPS without causing tissue hypoxia. Modulation of hemoglobin oxygen affinity represents a novel therapeutic approach to treatment of acute lung injury and acute respiratory distress syndrome, conditions characterized by hypoxemia.

scholarly journals Transfusion related acute lung injury with massive pulmonary secretion during cardiac surgery. A case report

2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Julien Teodori ◽  
Kamal Rampersad ◽  
Giovanni Teodori ◽  
Roland Roopchand ◽  
Gianni Davide Angelini
Keyword(s):  
Cardiac Surgery ◽  
Acute Lung Injury ◽  
Case Report ◽  
Lung Injury

scholarly journals Acute lung injury following gadolinium contrast: a case report

2021 ◽  
Vol 5 ◽  
pp. 18-18
Author(s):  
Alexandra Lucas ◽  
Gopi Mohan ◽  
Amanda Winkler ◽  
Kelly Gardner ◽  
Michael Whalen
Keyword(s):  
Acute Lung Injury ◽  
Case Report ◽  
Lung Injury ◽  
Gadolinium Contrast

scholarly journals Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report

2012 ◽  
Vol 4 (1) ◽  
pp. e2012020 ◽  
Author(s):  
Puneet Chhabra ◽  
Arjun Dutt law ◽  
Dr vikas Suri ◽  
Dr pankaj Malhotra ◽  
Dr subhash Varma
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Rare Event ◽  
Primary Cns Lymphoma ◽  
Cns Lymphoma ◽  
High Dose ◽  
Connective Tissue Disorders ◽  
High Dose Regimen ◽  
Dose Methotrexate

Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.

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