scholarly journals A case of Goodpasture's syndrome presenting with acute renal failure before pulmonary hemorrhage.

2001 ◽  
Vol 34 (8) ◽  
pp. 1205-1210
Author(s):  
Yoshiaki Nishioka ◽  
Yasuhide Kanamoto ◽  
Hiroshige Kawano ◽  
Masanobu Miyazaki ◽  
Takashi Harada ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Pulmonary Hemorrhage ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome

scholarly journals Acute Renal Failure in Elderly due to Goodpasture’s Syndrome

Nephron ◽  
1991 ◽  
Vol 57 (3) ◽  
pp. 381-382 ◽  
Author(s):  
A. Volpi ◽  
G. Battini ◽  
F. Conte ◽  
G.M. Ferrario ◽  
F. Giordano ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome

scholarly journals Goodpasture's syndrome: survival after acute renal failure.

BMJ ◽  
1967 ◽  
Vol 4 (5571) ◽  
pp. 95-95 ◽  
Author(s):  
J F Munro ◽  
A M Geddes ◽  
W L Lamb
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome

scholarly journals Pulmonary Hemorrhage and Acute Renal Failure as an Initial Presentation of Multiple Myeloma

2010 ◽  
Vol 49 (14) ◽  
pp. 1401-1403 ◽  
Author(s):  
Yoshikata Morita ◽  
Mako Yasuda ◽  
Mitsushige Nakao ◽  
Yoshinori Tsujimura ◽  
Motohide Isono
Keyword(s):  
Multiple Myeloma ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Pulmonary Hemorrhage ◽  
Initial Presentation

scholarly journals Fcγ Receptor Iib–Deficient Mice Develop Goodpasture's Syndrome upon Immunization with Type IV Collagen

2000 ◽  
Vol 191 (5) ◽  
pp. 899-906 ◽  
Author(s):  
Akira Nakamura ◽  
Takae Yuasa ◽  
Azusa Ujike ◽  
Masao Ono ◽  
Toshihiro Nukiwa ◽  
...  
Keyword(s):  
Rapidly Progressive Glomerulonephritis ◽  
Pulmonary Hemorrhage ◽  
Basement Membranes ◽  
Collagen Type Iv ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome ◽  
Type Iv ◽  
Suitable Animal Model ◽  
And Function

The combination of hemorrhagic pneumonitis and rapidly progressive glomerulonephritis is a characteristic feature of Goodpasture's syndrome (GPS), an autoimmune disease resulting from the interaction of pathogenic anti–collagen type IV (C-IV) antibodies with alveolar and glomerular basement membranes. Lack of a suitable animal model for this fatal disease has hampered both a basic understanding of its etiology and the development of therapeutic strategies. We now report a novel model for GPS using mice deficient in a central regulatory receptor for immunoglobulin (Ig)G antibody expression and function, the type IIB Fc receptor for IgG (FcγRIIB). Mutant mice immunized with bovine C-IV reproducibly develop massive pulmonary hemorrhage with neutrophil and macrophage infiltration and crescentic glomerulonephritis. The distinctive linear, ribbon-like deposition of IgG immune complex seen in GPS was observed along the glomerular and tubulointerstitial membranes of diseased animals. These results highlight the role of FcγRIIB in maintaining tolerance and suggest that it may play a role in the pathogenesis of human GPS.

Autoantibodies to native myeloperoxidase in patients with pulmonary hemorrhage and acute renal failure

1991 ◽  
Vol 11 (6) ◽  
pp. 389-397 ◽  
Author(s):  
Douglas E. Roberts ◽  
Carol Peebles ◽  
John G. Curd ◽  
Eng M. Tan ◽  
Robert L. Rubin
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Pulmonary Hemorrhage

scholarly journals Goodpasture's Syndrome and Silica: A Case Report and Literature Review

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
James Dahlgren ◽  
Marla Wardenburg ◽  
Trevor Peckham
Keyword(s):  
Renal Failure ◽  
Childhood Asthma ◽  
Acute Onset ◽  
Cigarette Use ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome ◽  
History Of Childhood ◽  
Silica Exposure ◽  
History Of ◽  
High Level

We report a case of Goodpasture's syndrome following chronic low level and an acute, high level of exposure to crystalline silica. A 38-year-old male tilesetter was admitted to the emergency room with dyspnea and respiratory failure. He reported that his symptoms had developed over the previous week after inhaling a large amount of dust while dry-sanding and sweeping a silica-based product used to fill cracks in a cement floor. Over the following days, his pulmonary function declined and he developed acute renal failure. Tests of antiglomerular basement membrane antibody were positive and renal biopsy revealed global glomerulonephritis. He was diagnosed with Goodpasture's syndrome and treated with steroids, plasmapheresis, and hemodialysis. This man had a history of childhood asthma and a remote, one pack-year history of cigarette use. He used the flooring product for seven years prior to the inciting event, however, previous jobs had utilized significantly smaller amounts. Goodpasture's syndrome and other autoimmune diseases have been reported in association with silica exposure. The acute onset following high level silica exposure in this previously healthy man, suggest that clinicians should investigate silica exposure as a causal factor in cases of Goodpasture's syndrome.

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