scholarly journals Les usagers des refuges : terra incognita de la fréquentation de la montagne ? Étude sur les refuges des Pyrénées centrales en haute saison touristique

2020 ◽  
pp. 47-64
Author(s):  
Olivier Hoibian
Keyword(s):  
Terra Incognita

Terra incognita Hausarztpraxis – Tabakentwöhnung in der deutschen Primärversorgung

2014 ◽  
Vol 60 (3) ◽  
pp. 175-187 ◽  
Author(s):  
Sven Schneider ◽  
Katharina Diehl ◽  
Christina Bock ◽  
Raphael M. Herr ◽  
Manfred Mayer ◽  
...  
Keyword(s):  
Status Quo ◽  
Expert Review ◽  
Terra Incognita

Zielsetzung: Die Hausarztpraxis gilt als ideales Setting für die Tabakentwöhnung. Die bundesweite „ÄSP-kardio-Studie“ liefert aktuelle Daten zum Status quo der Tabakentwöhnung nach der „5 A-Strategie“ in deutschen Hausarztpraxen. Methodik: Zwischen 10/2011 und 03/2012 wurden über 4.000 Hausärzte repräsentativ befragt. Der Fragebogen wurde vorab einem Expert Review unterzogen, durch kognitive Interviews validiert und in einer Pilotstudie getestet. Ergebnisse: Routinemäßig erfassten 89 % der Hausärzte etwaigen Tabakkonsum („Assess“), 82 % rieten Rauchern zu einem Rauchstopp („Advise“) und 12 % vereinbarten schriftliche Ziele einer Entwöhnung („Agree“). Hilfestellungen („Assist“) in Form einer Kurzintervention fanden mit 72 % deutlich häufiger statt als in Form von Informationsmaterial (33 %) oder einer Entwöhnungstherapie (27 %). Etwa die Hälfte (54 %) vereinbarte Folgetermine zur Überprüfung des Rauchstopps („Arrange“). Das Angebot war von arzt-, praxis- sowie patientenspezifischen Faktoren abhängig und in den nordöstlichen Bundesländern unterdurchschnittlich. Acht von 10 Hausärzten (77 %) bewerteten ihre Maßnahmen als nicht erfolgreich. Schlussfolgerungen: Deutlich wird die suboptimale und ungleich verteilte Versorgung von Rauchern mit angemessenen Entwöhnungsmaßnahmen in deutschen Hausarztpraxen.

Europäische Grundfreiheiten - terra incognita?

2000 ◽  
Vol 12 (3) ◽  
Author(s):  
Norbert Reich
Keyword(s):  
Terra Incognita

Am Beispiel eines Urteils des LG Düsseldorfwird die Praxis deutscher Gerichte untersucht, die Abwendung der Zwangsvollstreckung gegen Sicherheitsleistung durch eine Bankbürgschaft gerade einer deutschen oder im Inland ansässigen Bank oder Sparkasse zuzulassen. Dabei dräng} sich die Frage auf, ob der Ausschluß von Bankbürgschaften EG-ausländischer Banken und Sparkassen als prozessuale Sicherheiten etwa durch die Autonomie der Mitgliedstaaten hinsichtlich ihres Verfahrensrechts gerechtfertigt ist oder aber gegen den europarechtlichen Grundsatz der Dienstleistungsfreiheit verstößt

Possibilities and prospects of conservative therapy for endometriosis, as a chronical progressing disease (review of literature)

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Tatyana Yu. Pestrikova ◽  
Elena A. Yurasova ◽  
Igor V. Yurasov
Keyword(s):  
Quality Of Life ◽  
Abnormal Uterine Bleeding ◽  
Modern Medicine ◽  
Reproductive Age ◽  
Aim Analysis ◽  
Scientific Publications ◽  
Terra Incognita ◽  
Positive Effect

Relevance. Endometriosis is a common gynecological disease that affects up to 10% of women of reproductive age worldwide and is the main cause of pain and infertility. Endometriosis is a disease, although it has been known for a long time, nevertheless, in many ways it represents terra incognita for modern medicine. Aim. Analysis of literature on the feasibility of long-term and the use of the drug dienogest 2 mg (Vizanne), which has a positive effect on the quality of life of patients with endometriosis. Materials and methods. To write this review, a search was made for domestic and foreign publications in Russian and international search engines (PubMed, eLibrary, etc.) over the past 13 years. The review included articles from peer-reviewed literature. Results. The review presents data on the difficulties of verifying the diagnosis of endometriosis due to a combination of this pathology with pain, infertility, abnormal uterine bleeding. The pathogenesis of the origin of endometriosis-associated pain is presented. The efficacy of the use of the drug dienogest (Vizanne), which has a powerful antiproliferative effect that reduces the main symptoms of endometriosis (pain, bleeding), is substantiated. The expediency of long-term and safe use of the drug dienogest (Vizanne), which has a positive effect on the quality of life of patients with endometriosis, has been proved. Conclusions. Numerous scientific publications confirm the feasibility of prolonged use of the drug dienogest (Vizanne), to achieve remission during endometriosis.

Le français de spécialité, terra incognita universitaire

2016 ◽  
Vol 90 (1) ◽  
pp. 121-135
Author(s):  
Audrey Viguier
Keyword(s):  
Terra Incognita

scholarly journals Mutations in GDAP1 Influence Structure and Function of the Trans-Golgi Network

2021 ◽  
Vol 22 (2) ◽  
pp. 914
Author(s):  
Katarzyna Binięda ◽  
Weronika Rzepnikowska ◽  
Damian Kolakowski ◽  
Joanna Kaminska ◽  
Andrzej Antoni Szczepankiewicz ◽  
...  
Keyword(s):  
Golgi Apparatus ◽  
Experimental Therapy ◽  
Negative Effects ◽  
Gene Encoding ◽  
Charcot Marie Tooth Disease ◽  
Terra Incognita ◽  
And Function ◽  
Golgi Network ◽  
Cell Phenotypes ◽  
Tooth Disease

Charcot-Marie-Tooth disease (CMT) is a heritable neurodegenerative disease that displays great genetic heterogeneity. The genes and mutations that underlie this heterogeneity have been extensively characterized by molecular genetics. However, the molecular pathogenesis of the vast majority of CMT subtypes remains terra incognita. Any attempts to perform experimental therapy for CMT disease are limited by a lack of understanding of the pathogenesis at a molecular level. In this study, we aim to identify the molecular pathways that are disturbed by mutations in the gene encoding GDAP1 using both yeast and human cell, based models of CMT-GDAP1 disease. We found that some mutations in GDAP1 led to a reduced expression of the GDAP1 protein and resulted in a selective disruption of the Golgi apparatus. These structural alterations are accompanied by functional disturbances within the Golgi. We screened over 1500 drugs that are available on the market using our yeast-based CMT-GDAP1 model. Drugs were identified that had both positive and negative effects on cell phenotypes. To the best of our knowledge, this study is the first report of the Golgi apparatus playing a role in the pathology of CMT disorders. The drugs we identified, using our yeast-based CMT-GDAP1 model, may be further used in translational research.

scholarly journals Inhabiting terra incognita: Two-decadal patterns of negative human-leopard interactions in human-dominating landscape of Maharashtra, India

2021 ◽  
pp. e01740
Author(s):  
Kumar Ankit ◽  
Rucha Ghanekar ◽  
Bhumika Morey ◽  
Indranil Mondal ◽  
Vivek Khandekar ◽  
...  
Keyword(s):  
Terra Incognita

Small business development and tourism: Terra incognita?

1999 ◽  
Vol 20 (4) ◽  
pp. 435-459 ◽  
Author(s):  
S.J. Page ◽  
P. Forer ◽  
G.R. Lawton
Keyword(s):  
Small Business ◽  
Business Development ◽  
Small Business Development ◽  
Terra Incognita
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