scholarly journals Protection of ischemic brain metabolism by CBM 36-733 in spontaneously hypertensive rats.

Nosotchu ◽  
1991 ◽  
Vol 13 (4) ◽  
pp. 244-248
Author(s):  
Seizo Sadoshima ◽  
Yasushi Okada ◽  
Hiroshi Yao ◽  
Setsuro Ibayashi ◽  
Masatoshi Fujishima
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Brain Metabolism ◽  
Hypertensive Rats ◽  
Ischemic Brain ◽  
Spontaneously Hypertensive

scholarly journals Cilostazol, Not Aspirin, Reduces Ischemic Brain Injury via Endothelial Protection in Spontaneously Hypertensive Rats

Stroke ◽  
2011 ◽  
Vol 42 (9) ◽  
pp. 2571-2577 ◽  
Author(s):  
Naoki Oyama ◽  
Yoshiki Yagita ◽  
Miki Kawamura ◽  
Yukio Sugiyama ◽  
Yasukazu Terasaki ◽  
...  
Keyword(s):  
Brain Injury ◽  
Spontaneously Hypertensive Rats ◽  
Ischemic Brain Injury ◽  
Hypertensive Rats ◽  
Ischemic Brain ◽  
Spontaneously Hypertensive

scholarly journals Effects of arterial hypotension on brain metabolism in normotensive and spontaneously hypertensive rats.

Stroke ◽  
1981 ◽  
Vol 12 (3) ◽  
pp. 356-359 ◽  
Author(s):  
Y Nakatomi ◽  
M Fujishima ◽  
T Ishitsuka ◽  
K Tamaki ◽  
T Omae
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Brain Metabolism ◽  
Arterial Hypotension ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Excitatory and inhibitory amino acid changes in ischemic brain regions in spontaneously hypertensive rats

1991 ◽  
Vol 16 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Hiroaki Ooboshi ◽  
Hiroshi Yao ◽  
Takashi Matsumoto ◽  
Makoto Hirano ◽  
Hideyuki Uchimura ◽  
...  
Keyword(s):  
Amino Acid ◽  
Spontaneously Hypertensive Rats ◽  
Brain Regions ◽  
Hypertensive Rats ◽  
Ischemic Brain ◽  
Spontaneously Hypertensive

A preventive injection of endothelial progenitor cells prolongs lifespan in stroke-prone spontaneously hypertensive rats

2018 ◽  
Vol 132 (16) ◽  
pp. 1797-1810 ◽  
Author(s):  
Cheng Peng ◽  
Xiao-Hui Dong ◽  
Jia-Lin Liu ◽  
Yu-Long Tao ◽  
Chun-Fang Xu ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Spontaneously Hypertensive Rats ◽  
Single Injection ◽  
Ischemic Injury ◽  
Hypertensive Rats ◽  
Ischemic Brain ◽  
Spontaneously Hypertensive ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

There is a pressing need for new approaches to prevent stroke. Endothelial progenitor cells (EPCs) promote vascular repair and revascularization in the ischemic brain. The present study sought to evaluate whether preventive delivery of EPCs could prevent or protect against stroke. Stroke-prone spontaneously hypertensive rats (SHR-SP) received a single injection of EPCs, and their survival time was monitored. In addition, at 28 and/or 42 days after a single injection of EPCs, SHR-SP and mice were subjected to cerebral ischemia, and cerebral ischemic injury, local angiogenesis and in vivo EPC integration were determined. Other experiments examined the effects of EPC conditioned medium, and the distribution of donor EPCs taken from GFP transgenic mice. It was found that EPC-pretreated SHR-SP showed longer lifespans than untreated controls. A single preventive injection of EPCs could produce persistent protective effects against cerebral ischemic injury (lasting at least 42 days), and promote local angiogenesis in the ischemic brain, in two types of animals (SHR-SP and normotensive mice). EPCs of donor origin could be detected in the recipient peripheral blood, and integrated into the recipient ischemic brains. Furthermore, it was suggested that mouse EPCs might exert paracrine effects on cerebral ischemic injury in addition to their direct angiogenic effects. In conclusion, a single preventive injection of EPCs prolonged the lifespan of SHR-SP, and protected against cerebral ischemic injury for at least 7 weeks. It is implied that EPC injection might be a promising candidate for a preventive role in patients at high risk for stroke.

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