Novel Biodegradable Functional Amino Acid-Based Poly(ester Amide) Biomaterials: Design, Synthesis, Property and Biomedical Applications

2012 ◽  
Vol 5 (1) ◽  
pp. 1-31 ◽  
Author(s):  
C. C. Chu
Keyword(s):  
Amino Acid ◽  
Biomedical Applications ◽  
Design Synthesis

scholarly journals Recent Advances in Thermoresponsive OEGylated Poly(amino acid)s

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1813
Author(s):  
Chao Geng ◽  
Shixue Wang ◽  
Hongda Wang
Keyword(s):  
Amino Acid ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Synthesis Method ◽  
Structure Study ◽  
Thermoresponsive Polymers ◽  
Design Synthesis ◽  
Behavior Study ◽  
Potential Applications ◽  
Stimuli Response

Thermoresponsive polymers have been widely studied in the past decades due to their potential applications in biomedicine, nanotechnology, and so on. As is known, poly(N-isopropylacrylamide) (PNIPAM) and poly(oligo(ethylene glycol)methacrylates) (POEGMAs) are the most popular thermoresponsive polymers, and have been studied extensively. However, more advanced thermoresponsive polymers with excellent biocompatibility, biodegradability, and bioactivity also need to be developed for biomedical applications. OEGylated poly(amino acid)s are a kind of novel polymer which are synthesized by attaching one or multiple oligo(ethylene glycol) (OEG) chains to poly(amino acid) (PAA).These polymers combine the great solubility of OEG, and the excellent biocompatibility, biodegradability and well defined secondary structures of PAA. These advantages allow them to have great application prospects in the field of biomedicine. Therefore, the study of OEGylated poly(amino acid)s has attracted more attention recently. In this review, we summarized the development of thermoresponsive OEGylated poly(amino acid)s in recent years, including the synthesis method (such as ring-opening polymerization, post-polymerization modification, and Ugi reaction), stimuli-response behavior study, and secondary structure study. We hope that this periodical summary will be more conducive to design, synthesis and application of OEGylated poly(amino acid)s in the future.

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals Structurally nanoengineered antimicrobial peptide polymers: design, synthesis and biomedical applications

2021 ◽  
Vol 37 (8) ◽  
Author(s):  
Ronisha Ramamurthy ◽  
Chetan H. Mehta ◽  
Usha Y. Nayak
Keyword(s):  
Health Care ◽  
Antimicrobial Peptide ◽  
Biomedical Applications ◽  
Multidrug Resistant ◽  
Chronic Infections ◽  
Synthesis Mechanism ◽  
Design Synthesis ◽  
Global Health Care ◽  
Conventional Antibiotics ◽  
Peptide Polymers

Abstract Antimicrobial resistance not only increases the contagiousness of infectious diseases but also a threat for the future as it is one of the health care concern around the globe. Conventional antibiotics are unsuccessful in combating chronic infections caused by multidrug-resistant (MDR) bacteria, therefore it is important to design and develop novel strategies to tackle this problems. Among various novel strategies, Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs) have been introduced in recent years to overcome this global health care issue and they are found to be more efficient in their performance. Many facile methods are adapted to synthesize complex SNAPPs with required dimensions and unique functionalities. Their unique characteristics and remarkable properties have been exploited for their immense applications in various fields including biomedicine, targeting therapies, gene delivery, bioimaging, and many more. This review article deals with its background, design, synthesis, mechanism of action, and wider applications in various fields of SNAPPs. Graphic abstract

Biomedical applications of amino acid-modified chitosans: A review

Biomaterials ◽  
2012 ◽  
Vol 33 (30) ◽  
pp. 7565-7583 ◽  
Author(s):  
Luca Casettari ◽  
Driton Vllasaliu ◽  
Jenny K.W. Lam ◽  
Mahmoud Soliman ◽  
Lisbeth Illum
Keyword(s):  
Amino Acid ◽  
Biomedical Applications

In vivo metabolizable branched poly(ester amide) based on inositol and amino acids as drug nanocarrier for cancer therapy

2021 ◽  
Author(s):  
Jun Wu ◽  
Qi-Juan Yuan ◽  
Li Wang ◽  
Jun Huang ◽  
Wei Zhao
Keyword(s):  
Mechanical Property ◽  
Amino Acids ◽  
Amino Acid ◽  
Cancer Therapy ◽  
Biomedical Applications ◽  
Bioactive Components ◽  
Good Biocompatibility

Amino acid-based poly(ester amide) (PEA) has been utilized for various biomedical applications for its tunable mechanical property, good biocompatibility, and biodegradability. However, bioactive components have rarely been incorporated into the...

Yolk-Shell Nanostructures: Design, Synthesis, and Biomedical Applications

2017 ◽  
Vol 30 (6) ◽  
pp. 1704639 ◽  
Author(s):  
Li-Sen Lin ◽  
Jibin Song ◽  
Huang-Hao Yang ◽  
Xiaoyuan Chen
Keyword(s):  
Biomedical Applications ◽  
Design Synthesis ◽  
Shell Nanostructures

ChemInform Abstract: Design, Synthesis, SAR, and Biological Evaluation of Highly Potent Benzimidazole-Spaced Phosphono-α-amino Acid Competitive NMDA Antagonists of the AP-6 Type.

ChemInform ◽  
2010 ◽  
Vol 32 (35) ◽  
pp. no-no
Author(s):  
Reinhardt B. Baudy ◽  
Horace Fletcher III ◽  
John P. Yardley ◽  
Margaret M. Zaleska ◽  
Donna R. Bramlett ◽  
...  
Keyword(s):  
Amino Acid ◽  
Biological Evaluation ◽  
Nmda Antagonists ◽  
Design Synthesis ◽  
Competitive Nmda Antagonists

α-Amino Acid-Based Poly(Ester urea)s as Multishape Memory Polymers for Biomedical Applications

2016 ◽  
Vol 5 (10) ◽  
pp. 1176-1179 ◽  
Author(s):  
Gregory I. Peterson ◽  
Andrey V. Dobrynin ◽  
Matthew L. Becker
Keyword(s):  
Amino Acid ◽  
Biomedical Applications

Design, synthesis, and partial characterization of water-soluble .beta.-sheets stabilized by a dibenzofuran-based amino acid

1993 ◽  
Vol 115 (9) ◽  
pp. 3790-3791 ◽  
Author(s):  
Humberto Diaz ◽  
Kwok Yin Tsang ◽  
Danny Choo ◽  
Jose R. Espina ◽  
Jeffery W. Kelly
Keyword(s):  
Amino Acid ◽  
Beta Sheets ◽  
Water Soluble ◽  
Partial Characterization ◽  
Design Synthesis
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