scholarly journals Study of the effects of dietary polyunsaturated fatty acids: Molecular mechanisms involved in intestinal inflammation

2008 ◽  
Vol 60 (1) ◽  
Author(s):  
Warren C. McNabb ◽  
Bianca Knoch ◽  
Matthew P.G. Barnett ◽  
Nicole C. Roy
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Molecular Mechanisms ◽  
Intestinal Inflammation ◽  
Dietary Polyunsaturated Fatty Acids

INDUCTION OF APOPTOSIS IN HL-60 CELLS BY DIETARY POLYUNSATURATED FATTY ACIDS.

Shock ◽  
2001 ◽  
Vol 15 (Supplement) ◽  
pp. 73-74
Author(s):  
R. Gillis ◽  
P. Tithof ◽  
N. Neilsen ◽  
M. Barnhill ◽  
R. Andrews ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Dietary Polyunsaturated Fatty Acids ◽  
Induction Of Apoptosis

Maternal dietary polyunsaturated fatty acids in the early development of the immune system

2011 ◽  
Vol 668 ◽  
pp. e39-e40
Author(s):  
A. Hogenkamp⁎ ◽  
N. van Vlies ◽  
E. van Esch ◽  
A. Fear ◽  
P. Calder ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Immune System ◽  
Polyunsaturated Fatty Acids ◽  
Early Development ◽  
Dietary Polyunsaturated Fatty Acids

Function of dietary polyunsaturated fatty acids in the nervous system

1993 ◽  
Vol 48 (1) ◽  
pp. 5-15 ◽  
Author(s):  
J.M. Bourre ◽  
M. Bonneil ◽  
M. Clément ◽  
O. Dumont ◽  
G. Durand ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Nervous System ◽  
Polyunsaturated Fatty Acids ◽  
Dietary Polyunsaturated Fatty Acids

scholarly journals Chemopreventive effect of omega-3 polyunsaturated fatty acids and atorvastatin in rats with bladder cancer

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769225 ◽  
Author(s):  
Nahla E El-Ashmawy ◽  
Eman G Khedr ◽  
Hoda A El-Bahrawy ◽  
Samar M Al-Tantawy
Keyword(s):  
Fatty Acids ◽  
Bladder Cancer ◽  
Polyunsaturated Fatty Acids ◽  
Molecular Mechanisms ◽  
Combined Treatment ◽  
Lipid Peroxidation Product ◽  
Apoptotic Bodies ◽  
Omega 3 ◽  
Chemopreventive Effect ◽  
Anti Inflammatory

Bladder cancer remains a huge concern for the medical community because of its incidence and prevalence rates, as well as high percentage of recurrence and progression. Omega-3 polyunsaturated fatty acids and atorvastatin proved anti-inflammatory effects through peroxisome proliferator-activated receptor gamma mechanism. However, their chemopreventive effect still remained to be examined and clarified. In this study, bladder cancer was induced in rats by the chemical carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Omega-3 polyunsaturated fatty acids (docosahexaenoic acid and eicosapentaenoic acid: 2:3 w/w; 1200 mg/kg) and/or atorvastatin (6 mg/kg) were given orally daily to rats for eight consecutive weeks concomitantly with N-butyl-N-(4-hydroxybutyl)nitrosamine and continued for further 4 weeks after cessation of N-butyl-N-(4-hydroxybutyl)nitrosamine administration. The histopathological examination of rat bladder revealed the presence of tumors and the absence of apoptotic bodies in sections from N-butyl-N-(4-hydroxybutyl)nitrosamine group, while tumors were absent and apoptotic bodies were clearly observed in sections from rat groups treated with omega-3 polyunsaturated fatty acids, atorvastatin, or both drugs. The study of the molecular mechanisms illustrated downregulation of COX-2 and P53 (mutant) genes and suppression of transforming growth factor beta-1 and the lipid peroxidation product malondialdehyde in serum of rats of the three treated groups. This chemopreventive effect was confirmed by and associated with lower level of bladder tumor antigen in urine. However, the combined treatment with both drugs exhibited the major protective effect and nearly corrected the dyslipidemia that has been induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Collectively, omega-3 polyunsaturated fatty acids and atorvastatin, besides having anti-inflammatory properties, proved a chemopreventive effect against bladder cancer, which nominates them to be used as adjuvant therapy with other chemotherapeutics.

scholarly journals The Anti-Inflammatory and Antioxidant Properties of n-3 PUFAs: Their Role in Cardiovascular Protection

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 306 ◽  
Author(s):  
Francesca Oppedisano ◽  
Roberta Macrì ◽  
Micaela Gliozzi ◽  
Vincenzo Musolino ◽  
Cristina Carresi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Vascular Reactivity ◽  
Molecular Mechanisms ◽  
Antioxidant Properties ◽  
Cardiac Cells ◽  
Membrane Phospholipids ◽  
Mitochondrial Functions ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Polyunsaturated fatty acids (n-3 PUFAs) are long-chain polyunsaturated fatty acids with 18, 20 or 22 carbon atoms, which have been found able to counteract cardiovascular diseases. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in particular, have been found to produce both vaso- and cardio-protective response via modulation of membrane phospholipids thereby improving cardiac mitochondrial functions and energy production. However, antioxidant properties of n-3 PUFAs, along with their anti-inflammatory effect in both blood vessels and cardiac cells, seem to exert beneficial effects in cardiovascular impairment. In fact, dietary supplementation with n-3 PUFAs has been demonstrated to reduce oxidative stress-related mitochondrial dysfunction and endothelial cell apoptosis, an effect occurring via an increased activity of endogenous antioxidant enzymes. On the other hand, n-3 PUFAs have been shown to counteract the release of pro-inflammatory cytokines in both vascular tissues and in the myocardium, thereby restoring vascular reactivity and myocardial performance. Here we summarize the molecular mechanisms underlying the anti-oxidant and anti-inflammatory effect of n-3 PUFAs in vascular and cardiac tissues and their implication in the prevention and treatment of cardiovascular disease.

Sign in / Sign up

Export Citation Format

Share Document