Coumarin-containing Amino Acids and Oxy Acids as Chiral Discriminating Agents. Part III. Novel Crystalline (R)-(+)- and (S)-(-)-O-Coumarinyl Lactic Acids as Chiral Derivatizing Agents for 1H NMR Inspection of Optical Purities of Alcohols and Amines

Heterocycles ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 567 ◽  
Author(s):  
Kazuo Nagasawa ◽  
Noriko Seto ◽  
Keiichi Ito
Keyword(s):  
Amino Acids ◽  
1H Nmr ◽  
Chiral Derivatizing Agents ◽  
Lactic Acids

Synthesis and characterization of novel chiral derivatizing agents containing β-keto-anthracene adducts (KAAs) by 1H-NMR: aromatic influence and chiral alcohol absolute configuration determination

2019 ◽  
Vol 17 (3) ◽  
pp. 541-554
Author(s):  
Neeranuth Intakaew ◽  
Puracheth Rithchumpon ◽  
Chanatkran Prommin ◽  
Saranphong Yimklan ◽  
Nawee Kungwan ◽  
...  
Keyword(s):  
1H Nmr ◽  
Absolute Configuration ◽  
Synthesis And Characterization ◽  
Chiral Alcohols ◽  
Chiral Alcohol ◽  
Aromatic Rings ◽  
H Nmr ◽  
Chiral Derivatizing Agents

New chiral derivatizing agents and the effect of aromatic rings were investigated for absolute configuration of chiral alcohols via1H-NMR.

Discrimination of Enantiomers of Amides with Two Stereogenic Centers Enabled by Chiral Bisthiourea Derivatives Using 1H NMR Spectroscopy

2021 ◽  
Author(s):  
Hanchang Zhang ◽  
Hongmei Zhao ◽  
Jie Wen ◽  
Zhanbin Zhang ◽  
Pericles Stavropoulos ◽  
...  
Keyword(s):  
Amino Acids ◽  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Chiral Recognition ◽  
Stereogenic Centers

Enantiomers of a few new amides containing two stereogenic centers have been derived from D- and L-α-amino acids as guests for chiral recognition by 1H NMR spectroscopy. A variety of...

scholarly journals Changes in hepatic metabolic profile during the evolution of STZ-induced diabetic rats via an 1H NMR-based metabonomic investigation

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Minjiang Chen ◽  
Hong Zheng ◽  
Min Xu ◽  
Liangcai Zhao ◽  
Qianqian Zhang ◽  
...  
Keyword(s):  
Amino Acids ◽  
1H Nmr ◽  
Metabolic Pathways ◽  
Metabolic Profile ◽  
Diabetic Rats ◽  
Proton Nuclear Magnetic Resonance ◽  
Control Group ◽  
Resonance Spectroscopy ◽  
Discriminate Analysis ◽  
Protective Function

Abstract Background: The present study aimed to explore the changes in the hepatic metabolic profile during the evolution of diabetes mellitus (DM) and verify the key metabolic pathways. Methods: Liver samples were collected from diabetic rats induced by streptozotocin (STZ) and rats in the control group at 1, 5, and 9 weeks after STZ administration. Proton nuclear magnetic resonance spectroscopy (1H NMR)-based metabolomics was used to examine the metabolic changes during the evolution of DM, and partial least squares-discriminate analysis (PLS-DA) was performed to identify the key metabolites. Results: We identified 40 metabolites in the 1H NMR spectra, and 11 metabolites were further selected by PLS-DA model. The levels of α-glucose and β-glucose, which are two energy-related metabolites, gradually increased over time in the DM rats, and were significantly greater than those of the control rats at the three-time points. The levels of choline, betaine, and methionine decreased in the DM livers, indicating that the protective function in response to liver injury may be undermined by hyperglycemia. The levels of the other amino acids (leucine, alanine, glycine, tyrosine, and phenylalanine) were significantly less than those of the control group during DM development. Conclusions: Our results suggested that the hepatic metabolic pathways of glucose, choline-betaine-methionine, and amino acids were disturbed during the evolution of diabetes, and that choline-betaine-methionine metabolism may play a key role.

Strong spin-spin coupling in the two-dimensional J-resolved 360-MHz 1H NMR spectra of the common amino acids

1981 ◽  
Vol 42 (1) ◽  
pp. 73-87 ◽  
Author(s):  
Gerhard Wider ◽  
Rudolf Baumann ◽  
Kuniaki Nagayama ◽  
Richard R Ernst ◽  
Kurt Wüthrich
Keyword(s):  
Amino Acids ◽  
1H Nmr ◽  
Nmr Spectra ◽  
1H Nmr Spectra ◽  
Spin Coupling ◽  
Two Dimensional ◽  
The Common ◽  
Spin Spin Coupling ◽  
Strong Spin
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