Synthesis of 2-Substituted 2,3-Dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-3-ones as Potential Peripheral Benzodiazepine-Receptor Ligands

Andrea Cappelli; Maurizio Anzini; Salvatore Vomero

doi:10.3987/com-93-6520

Synthesis of 2-Substituted 2,3-Dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-3-ones as Potential Peripheral Benzodiazepine-Receptor Ligands

Heterocycles ◽

10.3987/com-93-6520 ◽

1994 ◽

Vol 38 (1) ◽

pp. 103 ◽

Cited By ~ 7

Author(s):

Andrea Cappelli ◽

Maurizio Anzini ◽

Salvatore Vomero

Keyword(s):

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl–2 inhibitor HA14–1

Zeitschrift für Gastroenterologie ◽

10.1055/s-2004-831695 ◽

2004 ◽

Vol 42 (08) ◽

Author(s):

A Sutter ◽

K Maaser ◽

P Grabowski ◽

M Höpfner ◽

A Krahn ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Cycle ◽

Cell Cycle Arrest ◽

Benzodiazepine Receptor ◽

Carcinoma Cells ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Cycle Arrest ◽

Human Hepatocellular Carcinoma Cells

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Specific high-affinity binding of peripheral benzodiazepine receptor ligands to brain tumors in rat and man

Cancer ◽

10.1002/1097-0142(19900101)65:1<93::aid-cncr2820650120>3.0.co;2-1 ◽

1990 ◽

Vol 65 (1) ◽

pp. 93-97 ◽

Cited By ~ 45

Author(s):

Keith L. Black ◽

Kiyonobu Ikezaki ◽

Emily Santori ◽

Donald P. Becker ◽

Harry V. Vinters

Keyword(s):

Brain Tumors ◽

Benzodiazepine Receptor ◽

Affinity Binding ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

High Affinity Binding ◽

Benzodiazepine Receptor Ligands ◽

High Affinity

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2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(01)00192-4 ◽

2001 ◽

Vol 9 (10) ◽

pp. 2661-2671 ◽

Cited By ~ 71

Author(s):

Silvia Selleri ◽

Fabrizio Bruni ◽

Camilla Costagli ◽

Annarella Costanzo ◽

Gabriella Guerrini ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1

Journal of Hepatology ◽

10.1016/j.jhep.2004.07.015 ◽

2004 ◽

Vol 41 (5) ◽

pp. 799-807 ◽

Cited By ~ 33

Author(s):

Andreas P. Sutter ◽

Kerstin Maaser ◽

Patricia Grabowski ◽

Gesine Bradacs ◽

Kirsten Vormbrock ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Cycle ◽

Cell Cycle Arrest ◽

Benzodiazepine Receptor ◽

Carcinoma Cells ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Cycle Arrest ◽

Human Hepatocellular Carcinoma Cells

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Modulation of intracellular calcium in human neutrophils by peripheral benzodiazepine receptor ligands

Journal of Chemotherapy ◽

10.1179/joc.1998.10.2.182 ◽

1998 ◽

Vol 10 (2) ◽

pp. 182-183 ◽

Cited By ~ 1

Author(s):

F. Marino ◽

M. Cosentino ◽

S. Cattaneo ◽

L. Di Grazia ◽

E. Caldiroli ◽

...

Keyword(s):

Intracellular Calcium ◽

Benzodiazepine Receptor ◽

Human Neutrophils ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Synthesis and structure–activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2007.06.044 ◽

2008 ◽

Vol 16 (6) ◽

pp. 3428-3437 ◽

Cited By ~ 10

Author(s):

Andrea Cappelli ◽

Germano Giuliani ◽

Salvatore Valenti ◽

Maurizio Anzini ◽

Salvatore Vomero ◽

...

Keyword(s):

Benzodiazepine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands ◽

Structure Activity

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Differential effects of anxiogenic central and peripheral benzodiazepine receptor ligands in tests of learning and memory

Psychopharmacology ◽

10.1007/bf02244187 ◽

1991 ◽

Vol 104 (2) ◽

pp. 249-254 ◽

Cited By ~ 19

Author(s):

Philip V. Holmes ◽

Robert C. Drugan

Keyword(s):

Learning And Memory ◽

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Differential Effects ◽

Benzodiazepine Receptor Ligands

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ChemInform Abstract: Molecular Basis of Peripheral versus Central Benzodiazepine Receptor Selectivity in a New Class of Peripheral Benzodiazepine Receptor Ligands Related to Alpidem (XII).

ChemInform ◽

10.1002/chin.199705175 ◽

2010 ◽

Vol 28 (5) ◽

pp. no-no

Author(s):

M. ANZINI ◽

A. CAPPELLI ◽

S. VOMERO ◽

G. GIORGI ◽

T. LANGER ◽

...

Keyword(s):

Molecular Basis ◽

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Receptor Selectivity ◽

Benzodiazepine Receptor Ligands ◽

New Class ◽

Central Benzodiazepine Receptor

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ChemInform Abstract: Synthesis of 2-Substituted 2,3-Dihydro-9-phenyl-1H-pyrrolo(3,4-b) quinolin-3-ones as Potential Peripheral Benzodiazepine-Receptor Ligands.

ChemInform ◽

10.1002/chin.199425143 ◽

2010 ◽

Vol 25 (25) ◽

pp. no-no

Author(s):

M. ANZINI ◽

A. CAPPELLI ◽

S. VOMERO

Keyword(s):

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Benzodiazepine Receptor Ligands

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Design, synthesis and structure–affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2003.10.050 ◽

2004 ◽

Vol 12 (2) ◽

pp. 423-438 ◽

Cited By ~ 103

Author(s):

Taketoshi Okubo ◽

Ryoko Yoshikawa ◽

Shigeyuki Chaki ◽

Shigeru Okuyama ◽

Atsuro Nakazato

Keyword(s):

Benzodiazepine Receptor ◽

Peripheral Benzodiazepine Receptor ◽

Receptor Ligands ◽

Design Synthesis ◽

Benzodiazepine Receptor Ligands

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