Facile Synthetic Methods for 3- and 5-Trifluoromethyl-4-trifluoroacetylpyrazoles and Their Conversion into Pyrazole-4-carboxylic Acids

Heterocycles ◽  
1992 ◽  
Vol 34 (4) ◽  
pp. 791 ◽  
Author(s):  
Masaru Hojo ◽  
Etsuji Okada ◽  
Ryoichi Masuda
Keyword(s):  
Carboxylic Acids ◽  
Synthetic Methods

Reagents and synthetic methods. 31. Silylations with N-trimethylsilyl-2-oxazolidinone (TMSO)

1984 ◽  
Vol 62 (2) ◽  
pp. 336-340 ◽  
Author(s):  
Jesús M. Aizpurua ◽  
Claudio Palomo ◽  
Antonio L. Palomo
Keyword(s):  
Carboxylic Acids ◽  
Synthetic Methods ◽  
Triflic Acid ◽  
Points Of View

Silylation of ketones, alcohols, mercaptans, and carboxylic acids with N-trimethylsilyl-2-oxazolidinone (TMSO) and triflic acid as catalyst has been described from synthetic and mechanistic points of view.

scholarly journals Direct β- and γ-C(sp3)–H Alkynylation of Free Carboxylic Acids

2020 ◽  
Author(s):  
Francesca Ghiringhelli ◽  
Manuel van Gemmeren
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Synthetic Methods ◽  
Broad Scope ◽  
Palladium Catalyzed ◽  
Directing Group

In this study we report the identification of a novel class of ligands for palladium-catalyzed C(sp3)–H activation that enables the direct alkynylation of free carboxylic acid substrates. In contrast to previous synthetic methods no introduction/removal of an exogenous directing group is required. A broad scope of acids including both α-quaternary and challenging α-non-quaternary can be used as substrates. Additionally, the alkynylation in the distal γ-position is reported. Finally, this study encompasses preliminary findings on an enantioselective variant of the title transformation as well as synthetic applications of the products obtained.

An Overview of Synthetic Methods for the Preparation of Halolactones

2019 ◽  
Vol 16 (1) ◽  
pp. 98-111 ◽  
Author(s):  
Małgorzata Grabarczyk ◽  
Katarzyna Wińska ◽  
Wanda Mączka
Keyword(s):  
Secondary Metabolites ◽  
Chemical Synthesis ◽  
Carboxylic Acids ◽  
Synthetic Methods ◽  
Unsaturated Esters ◽  
Racemic Mixtures ◽  
Unsaturated Carboxylic Acids ◽  
Living Organisms

Halolactones are used both in chemical synthesis as intermediates as well as in various industries. These compounds may be secondary metabolites of living organisms, although they are mainly obtained by chemical synthesis. The substrates for the synthesis of chloro-, bromo- and iodolactones are often unsaturated carboxylic acids, and sometimes they are unsaturated esters. The article presents a number of different methods for the production of halolactones, both racemic mixtures and enantiomerically enriched compounds.

Sign in / Sign up

Export Citation Format

Share Document