A New Method for Selective Protection of Two Hydroxyl Groups in Carbohydorates, Glycals in Particular

Heterocycles ◽  
1991 ◽  
Vol 32 (8) ◽  
pp. 1445 ◽  
Author(s):  
Cedric W. Holzapfel ◽  
Johan J. Huyser ◽  
Thilo L. van der Merwe ◽  
Fanie R. van Heerden
Keyword(s):  
New Method ◽  
Hydroxyl Groups ◽  
Selective Protection

ChemInform Abstract: A New Method for Selective Protection of Two Hydroxyl Groups in Carbohydrates, Glycals in Particular.

ChemInform ◽  
2010 ◽  
Vol 23 (4) ◽  
pp. no-no
Author(s):  
C. W. HOLZAPFEL ◽  
J. J. HUYSER ◽  
T. L. VAN DER MERWE ◽  
F. R. VAN HEERDEN
Keyword(s):  
New Method ◽  
Hydroxyl Groups ◽  
Selective Protection

New Method of Preparation of Brassinosteroids

1994 ◽  
Vol 59 (2) ◽  
pp. 457-460 ◽  
Author(s):  
Ladislav Kohout
Keyword(s):  
New Method ◽  
Hydroxyl Groups

Brassinosteroids with lactone B-ring (II and IV) were prepared by oxidation of the corresponding 6-keto derivatives I and III without protection of the hydroxyl groups against the action of the oxidation reagent.

scholarly journals A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Sira Defaus ◽  
Maria Gallo ◽  
María A. Abengózar ◽  
Luis Rivas ◽  
David Andreu
Keyword(s):  
Aminoglycoside Antibiotic ◽  
Cell Penetrating Peptides ◽  
Hydroxyl Groups ◽  
Selective Protection ◽  
Synthetic Strategy ◽  
Cell Penetrating ◽  
Successful Approach ◽  
Leishmania Parasites

A successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetrating peptides as vectors for efficiently transporting low-bioavailability drugs into cells.

scholarly journals An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin

2009 ◽  
Vol 5 ◽  
Author(s):  
Nian-Guang Li ◽  
Zhi-Hao Shi ◽  
Yu-Ping Tang ◽  
Jian-Ping Yang ◽  
Jin-Ao Duan
Keyword(s):  
Diphenyl Ether ◽  
Hydroxyl Groups ◽  
Partial Synthesis ◽  
Selective Protection ◽  
Catechol Group

An efficient partial 5-step synthesis of 4′-O-methylquercetin from quercetin in 63% yield is reported. This strategy relies on the selective protection of the catechol group with dichlorodiphenylmethane in diphenyl ether as solvent and on the selective protection of the hydroxyl groups at positions 3 and 7 with chloromethyl ether.

ChemInform Abstract: Selective Protection of the C7 and C10 Hydroxyl Groups in 10-Deacetyl Baccatin III

ChemInform ◽  
2010 ◽  
Vol 29 (30) ◽  
pp. no-no
Author(s):  
R. A. HOLTON ◽  
Z. ZHANG ◽  
P. A. CLARKE ◽  
H. NADIZADEH ◽  
D. J. PROCTER
Keyword(s):  
Hydroxyl Groups ◽  
Baccatin Iii ◽  
Selective Protection

scholarly journals Inhibition of pathophysiological proteases with novel quercetin derivatives

2013 ◽  
Vol 6 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Martina Danihelová ◽  
Miroslav Veverka ◽  
Ernest Šturdík
Keyword(s):  
Serine Proteases ◽  
Proteolytic Enzymes ◽  
Inhibitory Effect ◽  
Biological Properties ◽  
Hydroxyl Groups ◽  
Elastase Activity ◽  
Quercetin Derivatives ◽  
Selective Protection ◽  
Comparable Level ◽  
Micromolar Range

Abstract Novel quercetin derivatives were prepared to change its physicochemical properties and effects on activity of proteolytic enzymes. For them preparation, the selective protection procedures some of the quercetin hydroxyl groups and acylation of the others with acylchlorides were used. The ability of these compounds to inhibit the activity of serine proteases e.g. trypsin, thrombin, urokinase and elastase was studied. In micromolar range, tested derivatives were the most potent inhibitors of thrombin. There was estimated better inhibition of thrombin for prenylated, acetylated, feruloyl and caffeoyl quercetin esters. Slight inhibitory effect of all quercetin derivatives on elastase was found. Among tested derivatives only diquercetin displayed better inhibiton. Trypsin and urokinase were inhibited by quercetin at comparable level. Slight improvement in inhibitory effect of trypsin and urokinase was seen for chloronaphtoquinone quercetin that revealed enhanced inhibiton of thrombin, too. However, no influence on elastase activity was determined for this compound. Obtained results indicate that certain modifications of quercetin structure could improve its biological properties.

ChemInform Abstract: SELECTIVE PROTECTION OF HYDROXYL GROUPS IN DEOXYNUCLEOSIDES USING ALKYLSILYL REAGENTS

1974 ◽  
Vol 5 (48) ◽  
pp. no-no
Author(s):  
K. K. OGILVIE ◽  
E. A. THOMPSON ◽  
M. A. QUILLIAM ◽  
J. B. WESTMORE
Keyword(s):  
Hydroxyl Groups ◽  
Selective Protection
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