A Novel Synthesis of Cyclohexylnorstatine Isopropyl Ester, the C-Terminal Component of a Renin Inhibitor

Shiro Terashima; Yoshio Ito; Tetsuhide Kamijo; Hiromu Harada

doi:10.3987/com-89-s41

A Novel Synthesis of Cyclohexylnorstatine Isopropyl Ester, the C-Terminal Component of a Renin Inhibitor

Heterocycles ◽

10.3987/com-89-s41 ◽

1990 ◽

Vol 30 (1) ◽

pp. 299 ◽

Cited By ~ 3

Author(s):

Shiro Terashima ◽

Yoshio Ito ◽

Tetsuhide Kamijo ◽

Hiromu Harada

Keyword(s):

Renin Inhibitor ◽

Isopropyl Ester ◽

Novel Synthesis ◽

Terminal Component

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ChemInform Abstract: A Novel Synthesis of Cyclohexylnorstatine Isopropyl Ester, the C-Terminal Component of a Renin Inhibitor.

ChemInform ◽

10.1002/chin.199034279 ◽

1990 ◽

Vol 21 (34) ◽

Author(s):

Y. ITO ◽

T. KAMIJO ◽

H. HARADA ◽

S. TERASHIMA

Keyword(s):

Renin Inhibitor ◽

Isopropyl Ester ◽

Novel Synthesis ◽

Terminal Component

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Quantitation of 4-cyclohexyl-2-hydroxyl-3-(3-methylsulfanyl-2-{2- [(morpholine-4-carbonyl)amino]-3- phenylpropionylamino}propionylamino)butyric acid isopropyl ester (CP-80, 794), a renin inhibitor, and its hydrolytic cleavage metabolite 2-[(morphine-4-carbonyl)amino]-3-phenylpropionic acid (CP-84,364) in dog and human plasma by high-performance liquid chromatography

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/s0378-4347(97)00236-3 ◽

1997 ◽

Vol 696 (2) ◽

pp. 243-251 ◽

Cited By ~ 2

Author(s):

Mary C. Allen ◽

Caroline G. Stafford ◽

Mark R. Nocerini

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Human Plasma ◽

Butyric Acid ◽

High Performance ◽

Renin Inhibitor ◽

Isopropyl Ester ◽

Hydrolytic Cleavage ◽

Phenylpropionic Acid

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A novel synthesis of the (2R,3S)- and (2S3R)-3-amino-2-hydroxycarboxylic acid derivatives, the key components of a renin inhibitor and bestatin, from methyl (R)- and (S-mandelate

Tetrahedron Letters ◽

10.1016/s0040-4039(00)89018-8 ◽

1990 ◽

Vol 31 (21) ◽

pp. 3031-3034 ◽

Cited By ~ 45

Author(s):

Yuko Kobayashi ◽

Yoshiji Takemoto ◽

Yoshio Ito ◽

Shiro Terashima

Keyword(s):

Renin Inhibitor ◽

Hydroxycarboxylic Acid ◽

Novel Synthesis

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ChemInform Abstract: A Novel Synthesis of the (2R,3S)- and (2S,3R)-3-Amino-2- hydroxycarboxylic Acid Derivatives, the Key Components of a Renin Inhibitor, and Bestatin, from Methyl (R)- and (S)-Mandelate.

ChemInform ◽

10.1002/chin.199123242 ◽

2010 ◽

Vol 22 (23) ◽

pp. no-no

Author(s):

Y. KOBAYASHI ◽

Y. TAKEMOTO ◽

Y. ITO ◽

S. TERASHIMA

Keyword(s):

Renin Inhibitor ◽

Hydroxycarboxylic Acid ◽

Novel Synthesis

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Palladium-Catalyzed Asymmetric Annulation Between Aryl Iodides and Racemic Epoxides Using a Chiral Norbornene Cocatalyst

10.26434/chemrxiv.6635312 ◽

2018 ◽

Author(s):

Guangbin Dong ◽

Renhe Li

Keyword(s):

Isopropyl Ester ◽

Synthetic Route ◽

Initial Development ◽

Aryl Iodides ◽

Palladium Catalyzed

Herein, we describe our initial development of an asymmetric Pd-catalyzed annulation between aryl iodides and racemic epoxides for synthesis of 2,3-dihydrobenzofurans using a chiral norbornene cocatalyst. A series of enantiopure ester-, amide- and imide-substituted norbornenes have been prepared with a reliable synthetic route. Promising enantioselectivity (42-45% ee) has been observed using the isopropyl ester-substituted norbornene (N1*) and the amide-substituted norbornene (N7*).

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