Artificial Intelligence-Designed Stereoselective One-Pot Synthesis of trans-β-Lactams and Its Application to Cholesterol Absorption Inhibitor SCH 47949 Synthesis

Heterocycles ◽  
2020 ◽  
Vol 100 (1) ◽  
pp. 60
Author(s):  
Masahiro Toyota ◽  
Tetsuhiko Takabatake ◽  
Takumi Yoneda ◽  
Jyo Otsuka ◽  
Natsuko Kagawa
2020 ◽  
Vol 61 (36) ◽  
pp. 152275
Author(s):  
Tetsuhiko Takabatake ◽  
Keisuke Fujiwara ◽  
Sho Okamoto ◽  
Ryo Kishimoto ◽  
Natsuko Kagawa ◽  
...  

2020 ◽  
Author(s):  
Lucien Caspers ◽  
Julian Spils ◽  
Mattis Damrath ◽  
Enno Lork ◽  
Boris Nachtsheim

In this article we describe an efficient approach for the synthesis of cyclic diaryliodonium salts. The method is based on benzyl alcohols as starting materials and consists of an Friedel-Crafts-arylation/oxidation sequence. Besides a deep optimization, particluar focusing on the choice and ratios of the utilized Bronsted-acids and oxidants, we explore the substrate scope of this transformation. We also discuss an interesting isomerism of cyclic iodonium salts substituted with aliphatic substituents at the bridge head carbon. <br>


2017 ◽  
Vol 7 (12) ◽  
pp. 1192-1195
Author(s):  
Y. I. Shaikh ◽  
G. M. Nazeruddin ◽  
Khursheed Ahmed

2013 ◽  
Vol 30 (6) ◽  
pp. 636-642
Author(s):  
Xueli Zhang ◽  
Zhilan Lin ◽  
Huiling Hu ◽  
Jiaxin He ◽  
Yuan Gao

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