Facile Synthesis of Indolines by a Tandem Nitro-reduction Aza Michael Addition Reaction

Heterocycles ◽  
2013 ◽  
Vol 87 (10) ◽  
pp. 2023 ◽  
Author(s):  
Jason Guy Taylor ◽  
Wellington Martins Ventura ◽  
Luiz Guilherme Souza de Assis
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
Facile Synthesis ◽  
Nitro Reduction

ChemInform Abstract: Facile Synthesis of Indolines by a Tandem Nitro-Reduction Aza Michael Addition Reaction.

ChemInform ◽  
2014 ◽  
Vol 45 (9) ◽  
pp. no-no
Author(s):  
Wellington Martins Ventura ◽  
Luiz Guilherme Souza de Assis ◽  
Jason Guy Taylor
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
Facile Synthesis ◽  
Nitro Reduction

A Facile Synthesis of 1,6-Diketonesvia a Three-Component Michael Addition Reaction

Synlett ◽  
2003 ◽  
pp. 1506-1508 ◽  
Author(s):  
Romesh C Boruah ◽  
Anil Saikia ◽  
Apurba Chetia ◽  
Utpal Bora
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
Facile Synthesis

A facile synthesis of β-amino carbonyl compounds through an aza-Michael addition reaction under solvent-free conditions

RSC Advances ◽  
2014 ◽  
Vol 4 (20) ◽  
pp. 10188 ◽  
Author(s):  
Chao Huang ◽  
Yanqing Yin ◽  
Jiahui Guo ◽  
Jiong Wang ◽  
Baomin Fan ◽  
...  
Keyword(s):  
Michael Addition ◽  
Carbonyl Compounds ◽  
Addition Reaction ◽  
Solvent Free ◽  
Michael Addition Reaction ◽  
Facile Synthesis ◽  
Solvent Free Conditions

A Facile Synthesis of 1,6-Diketones via a Three-Component Michael Addition Reaction.

ChemInform ◽  
2003 ◽  
Vol 34 (50) ◽  
Author(s):  
Anil Saikia ◽  
Apurba Chetia ◽  
Utpal Bora ◽  
Romesh C. Boruah
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
Facile Synthesis

Cupin Variants as Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes

2019 ◽  
Author(s):  
Nobutaka Fujieda ◽  
Miho Yuasa ◽  
Yosuke Nishikawa ◽  
Genji Kurisu ◽  
Shinobu Itoh ◽  
...  
Keyword(s):  
Michael Addition ◽  
In Silico ◽  
Addition Reaction ◽  
Single Point ◽  
Point Mutations ◽  
Unsaturated Ketone ◽  
Michael Addition Reaction ◽  
Beta Barrel ◽  
Cupin Superfamily ◽  
Single Point Mutations

Cupin superfamily proteins (TM1459) work as a macromolecular ligand framework with a double-stranded beta-barrel structure ligating to a Cu ion through histidine side chains. Variegating the first coordination sphere of TM1459 revealed that H52A and H54A/H58A mutants effectively catalyzed the diastereo- and enantio-selective Michael addition reaction of nitroalkanes to an α,β-unsaturated ketone. Moreover, in silico substrate docking signified C106N and F104W single-point mutations, which inverted the diastereoselectivity of H52A and further improved the stereoselectivity of H54A/H58A, respectively.

Tandem Alkylation/Michael Addition Reaction of Dithiocarbamic Acids with Alkyl γ-Bromocrotonates: Access to Functionalized 1,3-Thiazolidine-2-thiones

Synthesis ◽  
2021 ◽  
Author(s):  
Azim Ziyaei Halimehjani ◽  
Petr Beier ◽  
Maryam Khalili Foumeshi ◽  
Ali Alaei ◽  
Blanka Klepetářová
Keyword(s):  
Amino Acids ◽  
Carbon Disulfide ◽  
Multicomponent Reaction ◽  
Michael Addition ◽  
Addition Reaction ◽  
Primary Amines ◽  
Oxidation Reactions ◽  
Michael Addition Reaction ◽  
Synthetic Utility ◽  
Reaction Proceeds

AbstractThiazolidine-2-thiones were prepared via a novel multicomponent reaction of primary amines (amino acids), carbon disulfide, and γ-bromocrotonates. The reaction proceeds via a domino alkylation/intramolecular Michael addition to provide the corresponding thiazolidine-2-thiones in high to excellent yields. By using diamines in this protocol, bis(thiazolidine-2-thiones) derivatives were synthesized. The synthetic utility of the adducts was demonstrated by hydrolysis, amidation, and oxidation reactions.

Bisphosphine catalyzed sequential [3 + 2] cycloaddition and Michael addition of ynones with benzylidenepyrazolones via dual α′,α′-C(sp3)–H bifunctionalization to construct cyclopentanone-fused spiro-pyrazolones

2018 ◽  
Vol 16 (48) ◽  
pp. 9461-9471 ◽  
Author(s):  
Jiayong Zhang ◽  
Zhiwei Miao
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction

A sequential [3 + 2] cycloaddition and Michael addition reaction of ynones with benzylidenepyrazolones afforded cyclopentanone-fused spiro-pyrazolones catalyzed by DPPB via dual α′,α′-C(sp3)–H bifunctionalization.

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