Studies on Pyrazine Derivatives. XLIX. Synthesis and Antibacterial Activity of 6-Methoxypyrazine-2-carboxylic Acid Hydrazide Derivatives

Heterocycles ◽  
2006 ◽  
Vol 68 (12) ◽  
pp. 2615 ◽  
Author(s):  
Katarzyna Gobis ◽  
Henryk Foks ◽  
Aleksandra Zuralska ◽  
Anna Kedzia
Keyword(s):  
Antibacterial Activity ◽  
Carboxylic Acid ◽  
Acid Hydrazide ◽  
Carboxylic Acid Hydrazide

New Hydrazide-hydrazone Derivatives of Quinoline 3-Carboxylic Acid Hydrazide: Synthesis, Theoretical Modeling and Antibacterial Evaluation

2019 ◽  
Vol 16 (5) ◽  
pp. 430-436 ◽  
Author(s):  
Ihsan Shabeeb ◽  
Luay Al-Essa ◽  
Majed Shtaiwi ◽  
Eveen Al-Shalabi ◽  
Eyad Younes ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carboxylic Acid ◽  
Density Functional ◽  
Acid Hydrazide ◽  
Biologically Active ◽  
Frontier Molecular Orbital ◽  
Chemical Structures ◽  
Carboxylic Acid Hydrazide ◽  
Quinoline Carboxylic Acid ◽  
Esherichia Coli

A series of biologically active 3-quinoline carboxylic acid hydrazide-hydrazones has been synthesized from 3-quinoline carboxylic acid hydrazide and a variety of aldehydes, with moderate to good yields. The chemical structures of the new products were confirmed by elemental analysis, IR, and 1H NMR, 13C NMR spectral data. The structural and frontier molecular orbital (FMO) properties and the density functional theory (DFT) calculations were conducted for the new compounds. The new hydrazide-hydrazones exhibited low to moderate antibacterial activity against Staphylococcus aureus and Esherichia coli in comparison with gentamycin. Among the tested compounds, compounds 9 and 13 were found to be the most active. Phthalimide derivative 2 of 3-quioline carboxylic acid hydrazide showed remarkable antibacterial activity.

scholarly journals A microwave-catalyzed rapid, efficient and ecofriendly synthesis of substituted pyrazol-5-ones (Short communication)

2003 ◽  
Vol 68 (10) ◽  
pp. 723-727 ◽  
Author(s):  
Vijay Dabholkar ◽  
Rahul Gavande
Keyword(s):  
Acetic Acid ◽  
Carboxylic Acid ◽  
Microwave Irradiation ◽  
Reaction Rate ◽  
Short Communication ◽  
Acid Hydrazide ◽  
Acetoacetic Ester ◽  
Carboxylic Acid Hydrazide ◽  
Conventional Methods

A series of 1-(3,4-dihydro-3-oxo-2H-1,4-benzoxazine-2-carbonyl)-3-methyl-4-(substituted phenylhydrazono)-2-pyrazolin-5-ones have been synthesized by the reaction of 2H-3,4-dihydro-3-oxo-1,4-benzoxazine-2-carboxylic acid hydrazide with substituted acetoacetic ester derivatives using acetic acid as solvent under microwave irradiation (MWI), as well as by conventional methods. The reaction rate is enhanced tremendously and the yields are improved under MWI as compared to conventional methods.

Synthesis of some pyrazole-3-carboxylic acid-hydrazide and pyrazolopyridazine compounds

2005 ◽  
Vol 42 (1) ◽  
pp. 117-120 ◽  
Author(s):  
İ Özer İlhan ◽  
Emin Saripinar ◽  
Yunus Akçamur
Keyword(s):  
Carboxylic Acid ◽  
Acid Hydrazide ◽  
Carboxylic Acid Hydrazide

Substitution of Cyano Group in Position 5 of 1,2,4-Triazines by Carboxylic Acid Hydrazide Residues under Solvent-Free Conditions

2018 ◽  
Vol 54 (3) ◽  
pp. 509-511 ◽  
Author(s):  
D. S. Kopchuk ◽  
A. P. Krinochkin ◽  
E. S. Starnovskaya ◽  
Ya. K. Shtaitz ◽  
I. S. Kovalev ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cyano Group ◽  
Acid Hydrazide ◽  
Solvent Free ◽  
Carboxylic Acid Hydrazide ◽  
Solvent Free Conditions

Fluorescent staining of glycoproteins in sodium dodecyl sulfate polyacrylamide gels by 4H-[1]-benzopyrano[4,3-b]thiophene-2-carboxylic acid hydrazide

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2764-2773 ◽  
Author(s):  
Zhongxin Zhu ◽  
Xuan Zhou ◽  
Yang Wang ◽  
Lisha Chi ◽  
Dandan Ruan ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Sodium Dodecyl Sulfate ◽  
Staining Method ◽  
Sodium Dodecyl ◽  
Acid Hydrazide ◽  
Polyacrylamide Gels ◽  
Fluorescent Staining ◽  
Affinity Enrichment ◽  
Carboxylic Acid Hydrazide ◽  
Sds Page

A sensitive, specific, economic and MS compatible staining method for gel-separated glycoproteins by using BH was described and demonstrated by 1-D and 2-D SDS-PAGE, deglycosylation, glycoprotein affinity enrichment and LC-MS/MS, respectively.

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