somatic gene conversion in polish family

2012 ◽  
pp. 2769 ◽  
Author(s):  
Emilia Kozlowska
Keyword(s):  
Gene Conversion ◽  
Somatic Gene

Somatic Gene Conversion

2016 ◽  
Author(s):  
Douglas M. Templeton ◽  
Michael Schwenk ◽  
Reinhild Klein ◽  
John H. Duffus
Keyword(s):  
Gene Conversion ◽  
Somatic Gene

scholarly journals Immunoglobulin gene conversion identification and analysis

2019 ◽  
Author(s):  
Stefano R. Bonissone
Keyword(s):  
Gene Conversion ◽  
False Positive Rate ◽  
Point Mutations ◽  
Immunoglobulin Gene ◽  
Additional Species ◽  
Germline Genes ◽  
Somatic Gene ◽  
Positive Rate ◽  
New Feature

ABSTRACTImmunoglobulins are highly diverse, diverging from their originating germline genes driven primarily by somatic recombination and hypermutation. However, somatic gene conversion is a strong driver of immunoglobulin diversity in some species, including rabbits and chickens. It is considerably harder to detect by sequence analysis than point mutations, and currently no dedicated tools exist for identifying these events. We present GECCO, the first dedicated gene conversion identification tool for immunoglobulins based on modified, simultaneous, pairwise alignments to host and donor references. We benchmark our approach on simulated repertoires and find GECCO has high recall, low false positive rate, and is insensitive to somatic mutations. We apply this new approach to characterize gene conversion events at the repertoire level in hyper-immunized rabbits, to show patterns of donor V gene preferences and donor tract length distributions. The dedicated gene conversion identification method we present allows for the characterization of a new feature of antibody repertoires that has not been possible thus far. GECCO will benefit future studies to explore the prevalence of immunoglobulin gene conversion in additional species.

Somatic Gene Conversion events in 11 children of CEPH Pedigree 1463

2012 ◽  
pp. 2723 ◽  
Author(s):  
Marcin von Grotthuss ◽  
Lucjan Wyrwicz ◽  
Krzysztof Ginalski ◽  
Leszek Rychlewski
Keyword(s):  
Gene Conversion ◽  
Somatic Gene

scholarly journals CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhiqian Li ◽  
Nimi Marcel ◽  
Sushil Devkota ◽  
Ankush Auradkar ◽  
Stephen M. Hedrick ◽  
...  
Keyword(s):  
Gene Conversion ◽  
Somatic Mutations ◽  
Genetic Screens ◽  
End Joining ◽  
Genetic Elements ◽  
Homology Directed Repair ◽  
Somatic Gene ◽  
Non Homologous End Joining ◽  
Or Gene ◽  
Therapy Strategies

AbstractCRISPR-based active genetic elements, or gene-drives, copied via homology-directed repair (HDR) in the germline, are transmitted to progeny at super-Mendelian frequencies. Active genetic elements also can generate widespread somatic mutations, but the genetic basis for such phenotypes remains uncertain. It is generally assumed that such somatic mutations are generated by non-homologous end-joining (NHEJ), the predominant double stranded break repair pathway active in somatic cells. Here, we develop CopyCatcher systems in Drosophila to detect and quantify somatic gene conversion (SGC) events. CopyCatchers inserted into two independent genetic loci reveal unexpectedly high rates of SGC in the Drosophila eye and thoracic epidermis. Focused RNAi-based genetic screens identify several unanticipated loci altering SGC efficiency, one of which (c-MYC), when downregulated, promotes SGC mediated by both plasmid and homologous chromosome-templates in human HEK293T cells. Collectively, these studies suggest that CopyCatchers can serve as effective discovery platforms to inform potential gene therapy strategies.

A human myeloma IgA with a hybrid heavy chain resulting from putative somatic gene conversion

1993 ◽  
Vol 23 (2) ◽  
pp. 364-368 ◽  
Author(s):  
Christine Silvain ◽  
Pierre Aucouturier ◽  
Isabelle Leduc ◽  
Edith Mihaesco ◽  
Jean-Louis Preud' Homme ◽  
...  
Keyword(s):  
Gene Conversion ◽  
Heavy Chain ◽  
Somatic Gene

scholarly journals Genetic Diversification by Somatic Gene Conversion

Genes ◽  
2011 ◽  
Vol 2 (1) ◽  
pp. 48-58 ◽  
Author(s):  
Kohei Kurosawa ◽  
Kunihiro Ohta
Keyword(s):  
Gene Conversion ◽  
Somatic Gene

Somatic Gene Therapy

1991 ◽  
Vol 5 (3) ◽  
pp. 423-432 ◽  
Author(s):  
Charles Hesdorffer ◽  
Dina Markowitz ◽  
Maureen Ward ◽  
Arthur Bank
Keyword(s):  
Gene Therapy ◽  
Somatic Gene Therapy ◽  
Somatic Gene
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