scholarly journals Primary Splenic Histiocytic Sarcoma Complicated by Protein-losing Gastroenteropathy and Pancytopenia

2000 ◽  
Vol 40 (4) ◽  
pp. 205-210
Author(s):  
Hideki MAKISHIMA ◽  
Kiyoshi KITANO
Keyword(s):  
Histiocytic Sarcoma

Case report of a mediastinal histiocytic sarcoma in a 27-year-old

2018 ◽  
Author(s):  
Antonia-Carmen Lisievici ◽  
Tiberiu Augustin Georgescu ◽  
Simona-Alina Barbu
Keyword(s):  
Case Report ◽  
Histiocytic Sarcoma

Histiocytic sarcoma of the urinary bladder in a dog

2011 ◽  
Vol 52 (12) ◽  
pp. 665-665 ◽  
Author(s):  
I. Amores-Fuster ◽  
J. W. Elliott ◽  
A. I. Freeman ◽  
L. Blackwood
Keyword(s):  
Urinary Bladder ◽  
Histiocytic Sarcoma

An Unusual Case Of Disseminated Histiocytic Sarcoma Preceded By Myeloid Sarcoma With Concomitant Acute Myeloid Leukemia

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S107-S108
Author(s):  
A C Reddy ◽  
K S Reddy
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Lymphoblastic Leukemia ◽  
Neck Mass ◽  
Histiocytic Sarcoma ◽  
Myeloid Sarcoma ◽  
Monocytic Differentiation ◽  
Tissue Samples ◽  
Disseminated Disease ◽  
Acute Myeloid

Abstract Introduction/Objective Histiocytic sarcoma (HS) is rare (<1% of hematolymphoid neoplasms), and can present extranodally as disseminated disease. Immunophenotypically, the cells express CD163, CD68, lysozyme and CD45. HS often occurs as a secondary event following B-cell lymphomas, acute lymphoblastic leukemia or acute myeloid leukemia (AML) typically with monocytic differentiation retaining the same molecular/cytogenetic abnormalities as the primary tumor. Results Our patient, a 47 year old male was diagnosed with myeloid sarcoma (MS) following FNA of a new neck mass. A bone marrow biopsy revealed AML without monocytic differentiation. Flow cytometric findings of both marrow and neck mass were similar (positive for CD34, CD117, CD33, CD11b, CD13, CD15, CD64, CD7; negative for CD4, CD14, CD56). Karyotypic and FLT3 ITD mutation analysis were normal. CNS involvement was diagnosed 2 months later, while a marrow biopsy (status post therapy) confirmed resolution of AML. A hypermetabolic left perinephric mass noted by PET CT, when biopsied, showed large epithelioid polygonal cells with amphophilic cytoplasm and atypical vesicular nuclei (positive for CD68, PU.1; negative for LCA, CD163, CD34, CD4, pankeratin). A diagnosis of atypical epithelioid neoplasm suggestive of HS was rendered, although negativity for LCA and CD163 was unusual. No treatment was given for HS. A month later, the patient presented with a cheek mass diagnosed again as being suggestive of HS. His AML also relapsed. Next-generation sequencing (37 genes including BRAF) from both marrow and tissue samples detected the presence of a nonsense mutation in exon 7 of WT1 (p.Ser169). Conclusion Our case appears to be the first reported one of disseminated HS preceded by MS and concomitant AML, lacking monocytic differentiation. The findings overall support the hypothesis of origin as being from a common progenitor cell differentiating along both myeloid and histiocytic/other cell lineages at different time points.

scholarly journals Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anaïs Prouteau ◽  
Jérôme Alexandre Denis ◽  
Pauline De Fornel ◽  
Edouard Cadieu ◽  
Thomas Derrien ◽  
...  
Keyword(s):  
Residual Disease ◽  
Specific Antigen ◽  
Point Mutations ◽  
Antigen Receptor ◽  
Digital Pcr ◽  
Circulating Tumor Dna ◽  
Histiocytic Sarcoma ◽  
Oncology Research ◽  
Tumor Dna

AbstractCirculating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. We detected ctDNA in 21/23 (91.3%) of histiocytic sarcoma (HS), 2/8 (25%) of oral melanoma, and 12/13 (92.3%) of lymphoma cases. The utility of ctDNA in diagnosing HS was explored in 133 dogs, including 49 with HS, and the screening of recurrent PTPN11 mutations in plasma had a specificity of 98.8% and a sensitivity between 42.8 and 77% according to the clinical presentation of HS. Sensitivity was greater in visceral forms and especially related to pulmonary location. Follow-up of four dogs by targeting lymphoma-specific antigen receptor rearrangement in plasma showed that minimal residual disease detection was concordant with clinical evaluation and treatment response. Thus, our study shows that ctDNA is detectable in the plasma of cancer-affected dogs and is a promising biomarker for diagnosis and clinical follow-up. ctDNA detection appears to be useful in comparative oncology research due to growing interest in the study of natural canine tumors and exploration of new therapies.

scholarly journals Intratumoral Canine Distemper Virus Infection Inhibits Tumor Growth by Modulation of the Tumor Microenvironment in a Murine Xenograft Model of Canine Histiocytic Sarcoma

2021 ◽  
Vol 22 (7) ◽  
pp. 3578
Author(s):  
Federico Armando ◽  
Adnan Fayyad ◽  
Stefanie Arms ◽  
Yvonne Barthel ◽  
Dirk Schaudien ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Virus Infection ◽  
Tumor Growth ◽  
Canine Distemper Virus ◽  
Xenograft Model ◽  
Histiocytic Sarcoma ◽  
Oncolytic Viruses ◽  
Canine Distemper ◽  
Murine Xenograft Model ◽  
The Impact

Histiocytic sarcomas refer to highly aggressive tumors with a poor prognosis that respond poorly to conventional treatment approaches. Oncolytic viruses, which have gained significant traction as a cancer therapy in recent decades, represent a promising option for treating histiocytic sarcomas through their replication and/or by modulating the tumor microenvironment. The live attenuated canine distemper virus (CDV) vaccine strain Onderstepoort represents an attractive candidate for oncolytic viral therapy. In the present study, oncolytic virotherapy with CDV was used to investigate the impact of this virus infection on tumor cell growth through direct oncolytic effects or by virus-mediated modulation of the tumor microenvironment with special emphasis on angiogenesis, expression of selected MMPs and TIMP-1 and tumor-associated macrophages in a murine xenograft model of canine histiocytic sarcoma. Treatment of mice with xenotransplanted canine histiocytic sarcomas using CDV induced overt retardation in tumor progression accompanied by necrosis of neoplastic cells, increased numbers of intratumoral macrophages, reduced angiogenesis and modulation of the expression of MMPs and TIMP-1. The present data suggest that CDV inhibits tumor growth in a multifactorial way, including direct cell lysis and reduction of angiogenesis and modulation of MMPs and their inhibitor TIMP-1, providing further support for the concept of its role in oncolytic therapies.

scholarly journals Disseminated mucocutaneous trichosporonosis in a patient with histiocytic sarcoma

2021 ◽  
Author(s):  
Arturo Robles-Tenorio ◽  
Rossy Anahí Rivas-López ◽  
Alexandro Bonifaz ◽  
Víctor Manuel Tarango-Martínez
Keyword(s):  
Histiocytic Sarcoma

scholarly journals Marginal zone lymphoma transdifferentiated to histiocytic sarcoma

2021 ◽  
Author(s):  
Peter J. B. Sabatini ◽  
Rosemarie M. A. Tremblay‐LeMay ◽  
Parnian Ahmadi Moghaddam ◽  
Jan M. A. Delabie ◽  
Ali Sakhdari
Keyword(s):  
Marginal Zone ◽  
Marginal Zone Lymphoma ◽  
Histiocytic Sarcoma

scholarly journals Genome‐wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients

2019 ◽  
Vol 67 (2) ◽  
Author(s):  
Matthias Bleeke ◽  
Pascal Johann ◽  
Susanne Gröbner ◽  
Julia Alten ◽  
Gunnar Cario ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Pediatric Patients ◽  
Histiocytic Sarcoma ◽  
Genome Wide Analysis ◽  
Genome Wide

BCR/ABL1 ‐positive histiocytic sarcoma of the small intestine in a patient with chronic myeloid leukaemia

2021 ◽  
Author(s):  
Hiroshi Minato ◽  
Yurie Okayama ◽  
Kazuyoshi Katayanagi ◽  
Chizuru Futatsuya ◽  
Hiroshi Kurumaya ◽  
...  
Keyword(s):  
Small Intestine ◽  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Histiocytic Sarcoma
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