scholarly journals An Autopsied Case of Primary Cutaneous Anaplastic Large Cell Lymphoma of CD4+ .ALPHA..BETA.T Cell Type with Expression of Cytotoxic Molecules Which Clinically Developed as Pyoderma-like Lesion.

2000 ◽  
Vol 40 (3) ◽  
pp. 157-165
Author(s):  
Noriko Sugiura ◽  
Hirotsugu Uda ◽  
Takehito Kozuka ◽  
Kunimitsu Kawahara ◽  
Akihiko Kurata ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Cell Type ◽  
Cytotoxic Molecules ◽  
Large Cell Lymphoma

Uniform Expression of Cytotoxic Molecules in Anaplastic Large Cell Lymphoma of Null/T Cell Phenotype and in Cell Lines Derived from Anaplastic Large Cell Lymphoma

Pathobiology ◽  
1997 ◽  
Vol 65 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Hans-Dieter Foss ◽  
Gudrun Demel ◽  
Ioannis Anagnostopoulos ◽  
Iguaracyra Araujo ◽  
Michael Hummel ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Cell Phenotype ◽  
Cytotoxic Molecules ◽  
Large Cell Lymphoma

Frequent Expression of the B-Cell–Specific Activator Protein in Reed-Sternberg Cells of Classical Hodgkin’s Disease Provides Further Evidence for Its B-Cell Origin

Blood ◽  
1999 ◽  
Vol 94 (9) ◽  
pp. 3108-3113 ◽  
Author(s):  
Hans-Dieter Foss ◽  
Regina Reusch ◽  
Gudrun Demel ◽  
Georg Lenz ◽  
Ioannis Anagnostopoulos ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Hodgkin’S Disease ◽  
Large Cell ◽  
Cell Type ◽  
Null Cell ◽  
Activator Protein ◽  
Large Cell Lymphoma

Abstract The neoplastic cells of classical Hodgkin’s disease (cHD), ie, Hodgkin and Reed-Sternberg cells (HRS cells), contain clonally rearranged Ig genes, but are dissimilar to normal B cells in that they mostly do not display B-cell antigens such as CD20 or CD19. The transcription factor B-cell–specific activator protein (BSAP) influences numerous B-cell functions such as B-cell antigen expression, Ig expression, and class switch. We analyzed the expression of BSAP in cHD and control tissues by isotopic in situ hybridization and immunohistochemistry to determine whether BSAP is expressed in HRS cells and, if so, whether it may be involved in the genesis of the abnormal phenotype of these cells. Both in normal lymphoid tissue and non-Hodgkin lymphomas, BSAP transcripts and protein were almost exclusively found in B cells and B-cell lymphomas (40 cases), but were absent from the tumor cells of T-cell neoplasms (41 cases), including 19 cases of anaplastic large cell lymphoma of T- and null-cell type. Among cHD, variable numbers of HRS cells exhibited BSAP transcripts (22 of 25 cases) and protein (28 of 31 cases). Our findings show that BSAP is sufficiently specific to serve as B-cell marker. BSAP expression in HRS cells provides further strong evidence for a frequent B-cell origin of cHD and helps distinguish this disease from anaplastic large cell lymphoma of T- and null-cell type. Because BSAP is much more frequently expressed in HRS cells than the conventional B-cell antigens, the abnormal immunophenotype of HRS cells with frequent absence of B-cell antigens does not appear to be due to absent BSAP expression.

Frequent Expression of the B-Cell–Specific Activator Protein in Reed-Sternberg Cells of Classical Hodgkin’s Disease Provides Further Evidence for Its B-Cell Origin

Blood ◽  
1999 ◽  
Vol 94 (9) ◽  
pp. 3108-3113 ◽  
Author(s):  
Hans-Dieter Foss ◽  
Regina Reusch ◽  
Gudrun Demel ◽  
Georg Lenz ◽  
Ioannis Anagnostopoulos ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Hodgkin’S Disease ◽  
Large Cell ◽  
Cell Type ◽  
Null Cell ◽  
Activator Protein ◽  
Large Cell Lymphoma

The neoplastic cells of classical Hodgkin’s disease (cHD), ie, Hodgkin and Reed-Sternberg cells (HRS cells), contain clonally rearranged Ig genes, but are dissimilar to normal B cells in that they mostly do not display B-cell antigens such as CD20 or CD19. The transcription factor B-cell–specific activator protein (BSAP) influences numerous B-cell functions such as B-cell antigen expression, Ig expression, and class switch. We analyzed the expression of BSAP in cHD and control tissues by isotopic in situ hybridization and immunohistochemistry to determine whether BSAP is expressed in HRS cells and, if so, whether it may be involved in the genesis of the abnormal phenotype of these cells. Both in normal lymphoid tissue and non-Hodgkin lymphomas, BSAP transcripts and protein were almost exclusively found in B cells and B-cell lymphomas (40 cases), but were absent from the tumor cells of T-cell neoplasms (41 cases), including 19 cases of anaplastic large cell lymphoma of T- and null-cell type. Among cHD, variable numbers of HRS cells exhibited BSAP transcripts (22 of 25 cases) and protein (28 of 31 cases). Our findings show that BSAP is sufficiently specific to serve as B-cell marker. BSAP expression in HRS cells provides further strong evidence for a frequent B-cell origin of cHD and helps distinguish this disease from anaplastic large cell lymphoma of T- and null-cell type. Because BSAP is much more frequently expressed in HRS cells than the conventional B-cell antigens, the abnormal immunophenotype of HRS cells with frequent absence of B-cell antigens does not appear to be due to absent BSAP expression.

Anaplastic large-cell lymphoma of null-cell type with multiple bone involvement

1998 ◽  
Vol 77 (6) ◽  
pp. 287-290 ◽  
Author(s):  
K. Suzukawa ◽  
H. Kojima ◽  
N. Mori ◽  
H. Y. Mukai ◽  
M. Hori ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Bone Involvement ◽  
Cell Type ◽  
Null Cell ◽  
Large Cell Lymphoma
Sign in / Sign up

Export Citation Format

Share Document