scholarly journals Unrelated Bone Marrow Transplantation Induced Long-Term Remission in a Patient with Life-Threatening Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

2011 ◽  
Vol 51 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Akane Kunitomi ◽  
Hiroshi Kimura ◽  
Yoshinori Ito ◽  
Kazuyuki Naitoh ◽  
Nobuhiko Noda ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Marrow Transplantation ◽  
Epstein Barr Virus ◽  
Unrelated Bone Marrow Transplantation ◽  
Barr Virus ◽  
Life Threatening ◽  
Epstein Barr

scholarly journals Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation

Blood ◽  
1988 ◽  
Vol 71 (5) ◽  
pp. 1234-1243 ◽  
Author(s):  
RS Shapiro ◽  
K McClain ◽  
G Frizzera ◽  
KJ Gajl-Peczalska ◽  
JH Kersey ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
B Cell ◽  
Marrow Transplantation ◽  
Cytogenetic Analysis ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disorders ◽  
Solid Organ ◽  
Barr Virus ◽  
Epstein Barr

Abstract B cell lymphoproliferative disorders (BLPD) developed in eight patients following bone marrow transplantation (BMT) for leukemia (five patients) or immunodeficiency (three patients). Recipients of T depleted marrow from a mismatched donor were at particularly high risk of this complication. Six of 25 (24%) recipients of mismatched T depleted bone marrow developed BLPD. In contrast, none of 47 matched T depleted transplants, one of ten (10%) who received non-depleted marrow from an unrelated donor, and only one of 424 matched non-depleted transplants were associated with BLPD. Epstein-Barr virus (EBV) specific serology and DNA hybridization studies demonstrating five to 50 copies of EBV genome/cell in involved tissues implicate this virus as an associated etiologic agent. Restriction fragment length polymorphism (RFLP) and cytogenetic analysis of involved tissue demonstrated donor origin (five of seven) or host origin (two of seven). Histologic appearance was similar to EBV-induced polymorphic B cell proliferations described following solid organ transplantation, or which occur de novo in primary immunodeficiency. Six of seven patients with adequate tissue available for study were found to have monoclonal proliferations by: in situ immunofluorescence (six of seven), and/or immunoglobulin gene rearrangement, (four of six). Cytogenetic analysis of involved tissues from four patients showed a normal karyotype, whereas two had multiple clonal chromosomal abnormalities. Seven patients died despite aggressive attempts at therapy with combinations of antiviral, immunologic, and chemotherapeutic agents.

Epstein-Barr Virus-Associated Smooth Muscle Tumors After Bone Marrow Transplantation

2014 ◽  
Vol 97 (1) ◽  
pp. e1-e5 ◽  
Author(s):  
Eiko Hayase ◽  
Katsuya Fujimoto ◽  
Tomoko Mitsuhashi ◽  
Yutaka Hatanaka ◽  
Miho Yoshida ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Smooth Muscle ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Smooth Muscle Tumors ◽  
Epstein Barr
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