scholarly journals Transient atelectasis due to hilar lymph node swelling affected by lenalidomide-induced tumor flare reaction

2021 ◽  
Author(s):  
Takahiro Suyama ◽  
Terue Yui ◽  
Atsuo Horiuchi ◽  
Rie Irie ◽  
Yoshiyuki Osamura ◽  
...  
Keyword(s):  
Lymph Node ◽  
Hilar Lymph Node ◽  
Lymph Node Swelling ◽  
Flare Reaction

scholarly journals Successful Alectinib Treatment for Carcinoma of Unknown Primary with EML4-ALK Fusion Gene: A Case Report

2021 ◽  
Vol 28 (3) ◽  
pp. 1938-1945
Author(s):  
Keiji Sugiyama ◽  
Ai Izumika ◽  
Akari Iwakoshi ◽  
Riko Nishibori ◽  
Mariko Sato ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cervical Lymph Node ◽  
Kinase Inhibitors ◽  
Fusion Gene ◽  
Liver Lesion ◽  
Lymph Node Biopsy ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Anaplastic Lymphoma ◽  
Lymph Node Swelling

Gene alteration in anaplastic lymphoma kinase (ALK) is rare, and the efficacy of ALK inhibitors in the treatment of carcinoma of unknown primary (CUP) with ALK alteration remains unclear. The patient was a 56-year-old woman who presented with cervical lymph node swelling. Computed tomography revealed paraaortic, perigastric, and cervical lymph node swelling; ascites; a liver lesion; and a left adrenal mass. A cervical lymph node biopsy was performed, and pathological diagnosis of an undifferentiated malignant tumor was conducted. Finally, the patient was diagnosed with CUP and treated with chemotherapy. To evaluate actionable mutations, we performed a multigene analysis, using a next-generation sequencer (FoundationOne® CDx). It revealed that the tumor harbored an echinoderm microtubule-associated protein-like 4 (EML4) and ALK fusion gene. Additionally, immunohistochemistry confirmed ALK protein expression. Alectinib, a potent ALK inhibitor, was recommended for the patient at a molecular oncology conference at our institution. Accordingly, alectinib (600 mg/day) was administered, and the multiple lesions and symptoms rapidly diminished without apparent toxicity. The administration of alectinib continued for a period of 10 months without disease progression. Thus, ALK-tyrosine kinase inhibitors should be considered in patients with CUP harboring the EML4-ALK fusion gene.

scholarly journals Colorectal Cancer Presenting as Single Pulmonary Hilar Lymph Node Metastasis

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Ahmed M. Habib ◽  
Xenophon Kassianides ◽  
Samuel Chan ◽  
Mahmoud Loubani ◽  
Syed Qadri
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Mediastinal Lymph Node ◽  
Lymph Node Involvement ◽  
Pulmonary Metastasectomy ◽  
Hilar Lymph Node ◽  
Node Metastasis ◽  
Mediastinal Metastasis ◽  
Node Involvement ◽  
Hilar Lymph Node Metastasis

Colorectal carcinoma is the second biggest cancer responsible for mortality. Lung metastasis is the commonest, following the liver. It is not uncommon to perform pulmonary metastasectomy and identify mediastinal metastasis. Previous studies have identified incidental lymph node involvement following routine mediastinal lymph node clearance in 20–50% of cases. However, solitary intrathoracic lymph node metastasis is exceedingly rare. Even when present, it is usually metachronous. In our case, we present an exceedingly rare case whereby the intrathoracic lymph node metastasis is solitary, not accompanying pulmonary disease and with no liver metastasis. We also review the evidence for mediastinal lymphadenectomy in the literature.

scholarly journals Primary Unknown Cancer in Pulmonary Hilar Lymph Node with Spontaneous Transient Regression: Report of a Case

1998 ◽  
Vol 28 (6) ◽  
pp. 405-409 ◽  
Author(s):  
H. Kawasaki ◽  
J. Yoshida ◽  
T. Yokose ◽  
K. Suzuki ◽  
K. Nagai ◽  
...  
Keyword(s):  
Lymph Node ◽  
Hilar Lymph Node

scholarly journals Impact of splenic hilar lymph node metastasis on prognosis in patients with advanced gastric cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (48) ◽  
pp. 84515-84528 ◽  
Author(s):  
Taeil Son ◽  
In Gyu Kwon ◽  
Joong Ho Lee ◽  
Youn Young Choi ◽  
Hyoung-Il Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Advanced Gastric Cancer ◽  
Hilar Lymph Node ◽  
Node Metastasis ◽  
Hilar Lymph Node Metastasis

Metastatic Lung Cancer Without Regional Lymph Node Swelling

CHEST Journal ◽  
2001 ◽  
Vol 120 (2) ◽  
pp. 689-690 ◽  
Author(s):  
Hiroaki Satoh ◽  
Hiroichi Ishikawa ◽  
Yuko T. Yamashita ◽  
Morio Ohtsuka ◽  
Kiyohisa Sekizawa
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Regional Lymph Node ◽  
Metastatic Lung Cancer ◽  
Metastatic Lung ◽  
Lymph Node Swelling

Station 10L. Excision of a posterior hilar lymph node on the left side

ASVIDE ◽  
2017 ◽  
Vol 4 ◽  
pp. 389-389
Author(s):  
Antonio E. Martin-Ucar ◽  
Laura Socci
Keyword(s):  
Lymph Node ◽  
Hilar Lymph Node
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