Total pancreatectomy and islet cell autotransplantation: Definitive treatment for chronic pancreatitis

2016 ◽  
Vol 83 (6) ◽  
pp. 435-442 ◽  
Author(s):  
Karla M. Arce ◽  
Yu Kuei Lin ◽  
Tyler Stevens ◽  
R. Matthew Walsh ◽  
Betul A. Hatipoglu
Keyword(s):  
Chronic Pancreatitis ◽  
Islet Cell ◽  
Total Pancreatectomy ◽  
Definitive Treatment

Total Pancreatectomy With and Without Islet Cell Transplantation for Chronic Pancreatitis

Pancreas ◽  
2009 ◽  
Vol 38 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Giuseppe Garcea ◽  
James Weaver ◽  
John Phillips ◽  
Cristina A. Pollard ◽  
Severine C. Ilouz ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Cell Transplantation ◽  
Islet Cell ◽  
Total Pancreatectomy ◽  
Islet Cell Transplantation

Increase in Postoperative Insulin Requirements Does Not Lead to Decreased Quality of Life after Total Pancreatectomy with Islet Cell Autotransplantation for Chronic Pancreatitis

2013 ◽  
Vol 79 (7) ◽  
pp. 676-680 ◽  
Author(s):  
Margaret Dorlon ◽  
Stephanie Owczarski ◽  
Hongjun Wang ◽  
David Adams ◽  
Katherine Morgan
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Chronic Pancreatitis ◽  
Islet Cell ◽  
Total Pancreatectomy ◽  
Daily Insulin ◽  
Insulin Requirements ◽  
Islet Autotransplantation ◽  
Component Scores

Previous studies have shown that total pancreatectomy with islet cell autotransplantation improves quality of life in chronic pancreatitis. A significant number of these patients develop postoperative hyperglycemia and daily insulin requirements or increase in daily insulin requirements. Our study investigates whether increased insulin requirements postoperatively have a negative impact on quality of life. A prospectively collected database of 74 patients undergoing extensive pancreatectomy with islet autotransplantation for pancreatitis was reviewed. Data pertaining to daily requirements and quality of life (QOL), as measured by the SF-12 questionnaire, in the preoperative and postoperative period were reviewed. Approval from the Institutional Review Board for the evaluation of human subjects was obtained. Seventy-four patients underwent extensive pancreatectomy with islet autotransplantation for pancreatitis. The majority of these patients required new daily insulin or an increase in daily insulin requirements post-operatively. Mean preoperative HA1c in this group was 5.6 with an increase to 7.3 at 6 months postoperatively ( P < 0.001), a mean of 8.1 at 12 months, and 8.9 at 2 years. Mean preoperative daily insulin requirements for this group were five units/day with average increase to 19 units/day at 6 months, 21 units/day at 12 months, and 26 units/day at 2 years. Preoperative QOL scores were a mean of 26 for the physical component and 36 for the mental health component. Postoperatively, physical component scores averaged 33 at 6 months (p < 0.001), 36 at 12 months, and 36 at 2 years; the mental health component scores averaged 42 at 6 months (p = 0.007), 41 at 12 months, and 41 at 2 years. There is no correlation between physical component score or mental component score QOL scores and daily insulin requirements ( r = -0.016 and r = 0.039, respectively). Total pancreatectomy with islet cell autotransplantation is an effective surgery for end-stage chronic pancreatitis. Quality of life significantly improves in physical and mental health components regardless of a postoperative increase in daily insulin requirements.

scholarly journals 194 – Pre-Operative Sarcopenia Predicts Low Islet Cell Yield Following Total Pancreatectomy with Islet Autotransplantation (TPIAT) for Chronic Pancreatitis (CP)

2019 ◽  
Vol 156 (6) ◽  
pp. S-1386
Author(s):  
Guru Trikudanathan ◽  
Ghislaine Feussom ◽  
Levi Teigen ◽  
Satish Munigala ◽  
Ahmed Dirweesh ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Islet Cell ◽  
Total Pancreatectomy ◽  
Cell Yield ◽  
Islet Autotransplantation

scholarly journals Total pancreatectomy with islet cell autotransplantation as the initial treatment for minimal-change chronic pancreatitis

HPB ◽  
2015 ◽  
Vol 17 (3) ◽  
pp. 232-238 ◽  
Author(s):  
Gregory C. Wilson ◽  
Jeffrey M. Sutton ◽  
Milton T. Smith ◽  
Nathan Schmulewitz ◽  
Marzieh Salehi ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Initial Treatment ◽  
Islet Cell ◽  
Total Pancreatectomy ◽  
Minimal Change

167-OR: Long-Term Follow-up after Total Pancreatectomy and Islet Cell Autotransplantation in Patients with Chronic Pancreatitis Utilizing Off-Site Islet Isolation

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 167-OR
Author(s):  
SALONI U. LAD ◽  
KHAWLA F. ALI ◽  
PHILIP C. JOHNSTON ◽  
VICENTE SAN MARTIN ◽  
YU KUEI LIN ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Islet Cell ◽  
Total Pancreatectomy ◽  
Islet Isolation ◽  
Long Term Follow Up
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