Survivors of sudden cardiac death: a rational approach to evaluation and therapy of patients surviving ventricular fibrillation

1992 ◽  
Vol 59 (2) ◽  
pp. 166-172 ◽  
Author(s):  
A. J. Rabinowitz ◽  
J. D. Maloney
Keyword(s):  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Cardiac Death ◽  
Rational Approach

scholarly journals Electrically-Induced Ventricular Fibrillation Alters Cardiovascular Function and Expression of Apoptotic and Autophagic Proteins in Rat Hearts

2019 ◽  
Vol 20 (7) ◽  
pp. 1628 ◽  
Author(s):  
Andras Czegledi ◽  
Agnes Tosaki ◽  
Alexandra Gyongyosi ◽  
Rita Zilinyi ◽  
Arpad Tosaki ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Cardiac Death ◽  
Caspase 3 ◽  
Recovery Period ◽  
Heart Rhythm ◽  
Heart Tissue ◽  
Altered Expression ◽  
Cardiac Functions ◽  
Rat Hearts

Background: The pathological heart contractions, called arrhythmias, especially ventricular fibrillation (VF), are a prominent feature of many cardiovascular diseases leading to sudden cardiac death. The present investigation evaluates the effect of electrically stimulated VF on cardiac functions related to autophagy and apoptotic mechanisms in isolated working rat hearts. Methods: Each group of hearts was subjected to 0 (Control), 1, 3, or 10 min of spacing-induced VF, followed by 120 min of recovery period and evaluated for cardiac functions, including aortic flow (AF), coronary flow (CF), cardiac output (CO), stroke volume (SV), and heart rate (HR). Hearts were also evaluated for VF effects on infarcted zone magnitude and Western blot analysis was conducted on heart tissue for expression of the apoptotic biomarker cleaved-caspase-3 and the autophagy proteins: p62, P-mTOR/mTOR, LC3BII/LC3BI ratio, and Atg5-12 complexes. Results: Data revealed that VF induced degradation in AF, CF, CO, and SV, which prominently included-variable post-VF capacity for recovery of normal heart rhythm; increased extent of infarcted heart tissue; altered expression of cleaved-caspase-3 suggesting potential for VF-mediated amplification of apoptosis. VF influence on expression of p62, LC3BII/LC3BI, and Atg5-12 proteins was complex, possibly due to differential effects of VF-induced expression on proteins comprising the autophagic program. Conclusions: VF was observed to cause time-dependent changes in autophagy processes, which with additional analysis under ongoing investigations, likely to yield novel therapeutic targets for the prevention of VF and sudden cardiac death.

scholarly journals Early repolarisation among athletes

2020 ◽  
Vol 6 (1) ◽  
pp. e000694
Author(s):  
Femke M A P Claessen ◽  
Heidi A P Peeters ◽  
Bastiaan J Sorgdrager ◽  
Peter L J van Veldhoven
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Outpatient Clinic ◽  
Cardiac Death ◽  
Multivariable Analysis ◽  
Control Group ◽  
Multivariable Logistic Regression Analysis ◽  
Athlete Group

ObjectivesTraditionally, early repolarisation (ER) is considered a benign ECG variant, predominantly found in youths and athletes. However, a limited number of studies have reported an association between ER and the incidental occurrence of ventricular fibrillation or sudden cardiac death. Yet definite, direct comparisons of the incidence of ER in unselected, contemporary populations in athletes as compared with non-athletes and across different sports are lacking. This study therefore aimed to investigate whether ER is more common among athletes as compared with non-athletes, and if ER patterns differ between sport disciplines based on static and dynamic intensity.MethodsTo assess ER we retrospectively analysed ECGs of 2241 adult subjects (2090 athletes, 151 non-athletes), who had a sports medical screening between 2010 and 2014 in an outpatient clinic. The outcome was tested for confounders in a multivariable logistic regression analysis.ResultsER was found in 502 athletes (24%). We found a 50% higher prevalence of ER in the athlete group compared with the control group (OR 1.5 (SE 0.34), adjusted 95% CI 1.0 to 2.4) in multivariable analysis. A 30% higher prevalence of ER in the inferior leads only (OR 1.3 (SE 0.38), adjusted 95% CI 0.74 to 2.3), a 120% higher prevalence of ER in the lateral leads only (OR 2.2 (SE 1.0), adjusted 95% CI 0.87 to 5.4), and a 20% higher prevalence of ER in the inferior and lateral leads (OR 1.2 (SE 0.49), adjusted 95% CI 0.55 to 2.7) was found in athletes.ConclusionAthletes had a 50% higher prevalence of ER and a 30% higher prevalence of ER in the inferior leads specifically. There was no association between training duration or sports discipline and ER.

Impact of Acute Coronary Syndrome Complicated by Ventricular Fibrillation on Long-term Incidence of Sudden Cardiac Death

2015 ◽  
Vol 68 (10) ◽  
pp. 878-884
Author(s):  
Belén Álvarez-Álvarez ◽  
Noelia Bouzas-Cruz ◽  
Emad Abu-Assi ◽  
Sergio Raposeiras-Roubin ◽  
Andrea López-López ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Cardiac Death ◽  
Coronary Syndrome

Sudden cardiac death secondary to demonstrated reperfusion ventricular fibrillation in a woman with Takotsubo cardiomyopathy

2011 ◽  
Vol 20 (4) ◽  
pp. 254-257 ◽  
Author(s):  
Martino Pepe ◽  
Domenico Zanna ◽  
Donato Quagliara ◽  
Carlo Caiati ◽  
Andrea Marzullo ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Takotsubo Cardiomyopathy ◽  
Cardiac Death

Myocardial imaging and radionuclide angiography in survivors of sudden cardiac death due to ventricular fibrillation: Preliminary report

1977 ◽  
Vol 39 (6) ◽  
pp. 852-857 ◽  
Author(s):  
James L. Ritchie ◽  
Glen W. Hamilton ◽  
Gene B. Trobaugh ◽  
W. Douglas Weaver ◽  
David L. Williams ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Cardiac Death ◽  
Preliminary Report ◽  
Radionuclide Angiography ◽  
Myocardial Imaging

Sudden cardiac death due to ventricular fibrillation caused by new SCN5A mutation

Heart Rhythm ◽  
2005 ◽  
Vol 2 (5) ◽  
pp. S291
Author(s):  
Alexander V. Chapurnykh ◽  
Elena V. Zaklazminskaya ◽  
Alexander V. Polyakov ◽  
Oleg V. Solovev ◽  
Victor V. Zlakazov
Keyword(s):  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Cardiac Death ◽  
Scn5a Mutation

MS-551 Protects Against Ventricular Fibrillation in a Chronic Canine Model of Sudden Cardiac Death

1995 ◽  
Vol 25 (2) ◽  
pp. 314-323 ◽  
Author(s):  
G. S. Friedrichs ◽  
L. Chi ◽  
M. R. Gralinski ◽  
S. C. Black ◽  
G. C. Easier ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Cardiac Death ◽  
Canine Model

scholarly journals Circadian variation of sudden cardiac death reflects age-related variability in ventricular fibrillation.

Circulation ◽  
1993 ◽  
Vol 88 (5) ◽  
pp. 2284-2289 ◽  
Author(s):  
H R Arntz ◽  
S N Willich ◽  
M Oeff ◽  
T Brüggemann ◽  
R Stern ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Ventricular Fibrillation ◽  
Cardiac Death ◽  
Circadian Variation ◽  
Age Related
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