Relationship of erythema nodosum to other manifestations of Crohn's disease

1977 ◽  
Vol 44 (4) ◽  
pp. 145-148 ◽  
Author(s):  
M. Jacobs ◽  
E. I. Winkelman ◽  
R. G. Farmer
2005 ◽  
Vol 19 (10) ◽  
pp. 603-606 ◽  
Author(s):  
Hugh J Freeman

Erythema nodosum and pyoderma gangrenosum may occur in Crohn's disease. In the present evaluation of consecutive patients with Crohn's disease spanning more than two decades, erythema nodosum was seen in 45 patients and pyoderma gangrenosum was seen in seven patients. Forty-one of 566 women (7.2%) and nine of 449 men (2.0%) were affected. Of these, 45 (4.4%) had erythema nodosum and seven (0.7%) had pyoderma gangrenosum, including two (0.2%) with both dermatological disorders at different times during their clinical courses. Recurrent erythema nodosum was also detected in nine patients (20%) including eight women, while recurrent pyoderma gangrenosum was seen in two patients (28.6%). There was an age-dependent effect on the appearance of erythema nodosum in women, with the highest percentages seen in those younger than 20 years of age. Detection rates for erythema nodosum in women only approached the low mens' rates in Crohn's disease at older than 40 years of age. Most patients with these dermatological disorders had colonic disease with or without ileal involvement as well as complex disease, usually with penetrating complications. The present study documents a sex-based and age-dependent effect on the clinical expression of erythema nodosum in Crohn's disease. This suggests that some components of the inflammatory process in Crohn's disease may be modulated by estrogen-mediated events, particularly in adolescents and young adults.


2007 ◽  
Vol 46 (s3) ◽  
pp. 27-29 ◽  
Author(s):  
Jaap J. A. J. van der Velden ◽  
Ariënne M. W. van Marion ◽  
Bernd Kremer ◽  
Jos M. J. A. A. Straetmans ◽  
Charles J. M. Henquet ◽  
...  

Dermatology ◽  
1999 ◽  
Vol 199 (2) ◽  
pp. 190-190 ◽  
Author(s):  
F. Châtillon ◽  
C. Chizzolini ◽  
G. Kaya ◽  
L. Borradori ◽  
C. Hauser

1990 ◽  
Vol 4 (2) ◽  
pp. 59-63 ◽  
Author(s):  
Robert Prokopetz ◽  
J Barrie Ross ◽  
Peter Smith ◽  
Joseph J Sidorov

A patient presented with skin lesions at sites not contiguous with Crohn's disease of the bowel and with specific histological features of Crohn's disease occurring two weeks from the onset of bowel symptoms. Currently a number of nonspecific skin conditions such as erythema nodosum, pyoderma gangrenosum and erythema multiforme are accepted as being the most common skin manifestations of Crohn's disease. It is likely, however, that specific lesions of Crohn's disease in the skin have been underdiagnosed either because of lack of biopsy or misinterpretation of the histology. Twenty-three cases with specific Crohn's disease in the skin have been recorded in the past 25 years, since the condition has been recognized. Sarcoidosis has been a common misdiagnosis. The literature relating to multicentric Crohn's disease is reviewed and attention drawn to its protean and masquerading features. An argument is made for the use of the term 'multicentric' rather than 'metastatic' in relation to cutaneous Crohn's disease.


2009 ◽  
Vol 62 (6) ◽  
pp. e155-e156 ◽  
Author(s):  
Alessandra Campa ◽  
Davide Lazzeri ◽  
Anna Brafa ◽  
Massimiliano Calabrò ◽  
Giuseppe Nisi ◽  
...  

2011 ◽  
Vol 22 ◽  
pp. S22
Author(s):  
Lurdes Correia ◽  
Rita Monteiro ◽  
Luís Rodrigues ◽  
Adélia Simão ◽  
Armando Carvalho ◽  
...  

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