scholarly journals Intervention Trials with the Mediterranean Diet in Cardiovascular Prevention: Understanding Potential Mechanisms through Metabolomic Profiling

2015 ◽  
Vol 146 (4) ◽  
pp. 913S-919S ◽  
Author(s):  
Miguel Á Martínez-González ◽  
Miguel Ruiz-Canela ◽  
Adela Hruby ◽  
Liming Liang ◽  
Antonia Trichopoulou ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Cardiovascular Prevention ◽  
Metabolomic Profiling ◽  
The Mediterranean ◽  
Intervention Trials

scholarly journals Application of 1H-NMR Metabolomics for the Discovery of Blood Plasma Biomarkers of a Mediterranean Diet

Metabolites ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 201 ◽  
Author(s):  
Shirin Macias ◽  
Joseph Kirma ◽  
Ali Yilmaz ◽  
Sarah E. Moore ◽  
Michelle C. McKinley ◽  
...  
Keyword(s):  
Citric Acid ◽  
Mediterranean Diet ◽  
1H Nmr ◽  
Pyruvic Acid ◽  
Plasma Metabolites ◽  
Dietary Biomarkers ◽  
Metabolomic Profiling ◽  
1H Nuclear Magnetic Resonance ◽  
Sweet Foods ◽  
The Mediterranean

The Mediterranean diet (MD) is a dietary pattern well-known for its benefits in disease prevention. Monitoring adherence to the MD could be improved by discovery of novel dietary biomarkers. The MEDiterranean Diet in Northern Ireland (MEDDINI) intervention study monitored the adherence of participants to the MD for up to 12 months. This investigation aimed to profile plasma metabolites, correlating each against the MD score of participants (n = 58). Based on an established 14-point scale MD score, subjects were classified into two groups (“low” and “high”). 1H-Nuclear Magnetic Resonance (1H-NMR) metabolomic analysis found that citric acid was the most significant metabolite (p = 5.99 × 10−4*; q = 0.03), differing between ‘low’ and ‘high’. Furthermore, five additional metabolites significantly differed (p < 0.05; q < 0.35) between the two groups. Discriminatory metabolites included: citric acid, pyruvic acid, betaine, mannose, acetic acid and myo-inositol. Additionally, the top five most influential metabolites in multivariate models were also citric acid, pyruvic acid, betaine, mannose and myo-inositol. Metabolites significantly correlated with the consumption of certain food types. For example, citric acid positively correlated fruit, fruit juice and vegetable constituents of the diet, and negatively correlated with sweet foods alone or when combined with carbonated drinks. Citric acid was the best performing biomarker and this was enhanced by paired ratio with pyruvic acid. The present study demonstrates the utility of metabolomic profiling for effectively assessing adherence to MD and the discovery of novel dietary biomarkers.

Central obesity and the Mediterranean diet: A systematic review of intervention trials

2017 ◽  
Vol 58 (18) ◽  
pp. 3070-3084 ◽  
Author(s):  
C. L. Bendall ◽  
H. L. Mayr ◽  
R. S. Opie ◽  
M. Bes-Rastrollo ◽  
C. Itsiopoulos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mediterranean Diet ◽  
Central Obesity ◽  
The Mediterranean ◽  
Intervention Trials

scholarly journals Is the Mediterranean diet adequate to satisfy zinc requirements during adolescence?

2012 ◽  
Vol 15 (8) ◽  
pp. 1429-1436 ◽  
Author(s):  
Marta Mesías ◽  
Isabel Seiquer ◽  
M Pilar Navarro
Keyword(s):  
Mediterranean Diet ◽  
Growth Parameters ◽  
Atomic Absorption Spectrophotometry ◽  
Growth Spurt ◽  
Male Adolescents ◽  
Flame Atomic Absorption ◽  
The Mediterranean ◽  
Intervention Trials ◽  
Zn Status ◽  
Medical Questionnaire

AbstractObjectiveTo evaluate Zn utilization and status among a sample of Spanish boys consuming a diet based on Mediterranean patterns.DesignDietary Zn balance was assessed by means of Zn intake in food and Zn output in faeces and urine as measured by flame atomic absorption spectrophotometry. In addition, biomarkers of Zn status were analysed.SettingProvince of Granada, Spain.SubjectsTwenty healthy male adolescents aged 11–14 years, selected based on medical questionnaire, physical examination and nutritional survey of food habits and lifestyle.ResultsMean Zn intake was 11·36 (se 0·31) mg/d, 76% of the recommended value for Spanish adolescents. Zn absorption (2·53 (se 0·55) mg/d) was close to the value of 3·0 mg/d required for the growth spurt. Zn status biomarkers and growth parameters were within the normal values for this age group.ConclusionsAlthough a diet based on Mediterranean patterns is associated with factors which can affect Zn absorption, such as high consumption of phytate, its consumption in adequate amounts allows Zn status to be maintained during adolescence. Due to the importance of Zn in preventing growth and behavioural disorders among adolescents, long-term intervention trials to investigate the suitability of the Mediterranean diet with respect to Zn requirements at this time of life are needed.

scholarly journals Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention

2016 ◽  
Vol 17 (9) ◽  
pp. 1469 ◽  
Author(s):  
Montserrat Fitó ◽  
Olle Melander ◽  
José Martínez ◽  
Estefanía Toledo ◽  
Christian Carpéné ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Cardiovascular Prevention ◽  
Diet Intervention ◽  
The Mediterranean

Homocysteine Levels Show Significant Differences among Mediterranean Dietary Quality Index Variables Compared to Folate and Vitamin B12 Status in Women

2015 ◽  
Vol 85 (3-4) ◽  
pp. 202-210 ◽  
Author(s):  
Ivona Višekruna ◽  
Ivana Rumbak ◽  
Ivana Rumora Samarin ◽  
Irena Keser ◽  
Jasmina Ranilović
Keyword(s):  
Mediterranean Diet ◽  
Diet Quality ◽  
Quality Index ◽  
Fruits And Vegetables ◽  
Reproductive Age ◽  
Dietary Quality ◽  
Vitamin B ◽  
Cross Sectional ◽  
Poor Diet ◽  
The Mediterranean

Abstract. Results of epidemiologic studies and clinical trials have shown that subjects following the Mediterranean diet had lower inflammatory markers such as homocysteine (Hcy). Therefore, the aim of this cross-sectional study was to assess female diet quality with the Mediterranean diet quality index (MDQI) and to determine the correlation between MDQI, homocysteine, folate and vitamin B12 levels in the blood. The study participants were 237 apparently healthy women (96 of reproductive age and 141 postmenopausal) between 25 and 93 years. For each participant, 24-hour dietary recalls for 3 days were collected, MDQI was calculated, and plasma Hcy, serum and erythrocyte folate and vitamin B12 levels were analysed. Total MDQI ranged from 8 to 10 points, which represented a medium-poor diet for the subjects. The strength of correlation using biomarkers, regardless of group type, age, gender and other measured parameters, was ranked from best (0.11) to worst (0.52) for olive oil, fish, fruits and vegetables, grains, and meat, in this order. Hcy levels showed the best response among all markers across all groups and food types. Our study shows significant differences between variables of the MDQI and Hcy levels compared to levels of folate and vitamin B12 in participants with medium-poor diet quality, as evaluated according to MDQI scores.

The Mediterranean Diet and Two-Year Changes in Cognitive Function in Puerto Rican Adults With vs. Without Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 192-LB
Author(s):  
JOSIEMER MATTEI ◽  
SHERMAN J. BIGORNIA ◽  
MERCEDES SOTOS-PRIETO ◽  
TAMMY SCOTT ◽  
XIANG GAO ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Function ◽  
Puerto Rican ◽  
Mediterranean Diet ◽  
The Mediterranean
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