scholarly journals Short-Chain Fatty Acids Enhance Adipocyte Differentiation in the Stromal Vascular Fraction of Porcine Adipose Tissue

2014 ◽  
Vol 144 (12) ◽  
pp. 1887-1895 ◽  
Author(s):  
Genlai Li ◽  
Wen Yao ◽  
Honglin Jiang
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Adipocyte Differentiation ◽  
Stromal Vascular Fraction ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

scholarly journals Short-chain fatty acids as novel therapeutics for gestational diabetes

2020 ◽  
Vol 65 (2) ◽  
pp. 21-34
Author(s):  
Rebecca Roy ◽  
Caitlyn Nguyen-Ngo ◽  
Martha Lappas
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Gestational Diabetes ◽  
Insulin Signalling ◽  
Short Chain Fatty Acids ◽  
Serine Phosphorylation ◽  
Short Chain ◽  
Low Grade ◽  
Chain Fatty Acids

Gestational diabetes mellitus (GDM) affects up to 16% of pregnant women and is associated with significant long-term health detriments for the mother and her offspring. Two central features of GDM are low-grade inflammation and maternal peripheral insulin resistance, therefore therapeutics which target these may be most effective at preventing the development of GDM. Short-chain fatty acids (SCFAs), such as butyrate and propionate, are metabolites produced from the fermentation of dietary fibre by intestinal microbiota. SCFAs possess anti-inflammatory, anti-obesity and anti-diabetic properties. Therefore, this study aimed to investigate the effect of SCFAs on inflammation and insulin signalling defects in an in vitro model of GDM. Human placenta, visceral adipose tissue (VAT) and s.c. adipose tissue (SAT) were stimulated with either the pro-inflammatory cytokine TNF or bacterial product lipopolysaccharide (LPS). The SCFAs butyrate and propionate blocked TNF- and LPS-induced mRNA expression and secretion of pro-inflammatory cytokines and chemokines in placenta, VAT and SAT. Primary human cells isolated from skeletal muscle were stimulated with TNF to assess the effect of SCFAs on inflammation-induced defects in the insulin signalling pathway. Butyrate and propionate were found to reverse TNF-induced increases in IRS-1 serine phosphorylation and decreases in glucose uptake. Butyrate and propionate exerted these effects by preventing ERK activation. Taken together, these results suggest that the SCFAs may be able to improve insulin sensitivity and prevent inflammation induced by sterile or bacterial inflammation. Future in vivo studies are warranted to investigate the efficacy and safety of SCFAs in preventing insulin resistance and inflammation associated with GDM.

scholarly journals Effects of Different Concentrations of Ganpu Tea on Fecal Microbiota and Short Chain Fatty Acids in Mice

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3715
Author(s):  
Chen Wang ◽  
Zhipeng Gao ◽  
Yujiao Qian ◽  
Xiang Li ◽  
Jieyi Wang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Dietary Therapy ◽  
Health Food ◽  
Intestinal Microorganisms ◽  
Positive Effects ◽  
Chain Fatty Acids

Ganpu tea is composed of tangerine peel and Pu-erh tea. Current research suggests that both products can interact with gut microbes and thus affect health. However, as a kind of compound health food, little information is available about the effect of Ganpu tea on intestinal microorganisms. In this study, the basic physiological parameters (body weight, white adipose tissue and serum fat), the regulation of intestinal microorganisms and content of short-chain fatty acids (SCFAs) in feces of healthy mice were studied. The Ganpu tea can reduce the weight gain of mice and the increase in white adipose tissue (p < 0.01). After the intake of Ganpu tea, the abundance of Bacteroidetes increased (p < 0.05), whereas that of Firmicutes decreased (p < 0.01), indicating the latent capacity of Ganpu tea in adjusting the gut microbiota. Moreover, Ganpu tea differentially affected the content of different types of SCFAs in feces. Ganpu tea at the lowest concentrations showed positive effects on the concentrations of SCFAs such as acetic acid and propionic acid, whereas the concentration of butyric acid was decreased. For branched short-chain fatty acids (BSCFAs) such as isobutyric acid, isovaleric acid, etc., Ganpu tea reduced their concentrations. Our results indicated that Ganpu tea may have positive effects on preventing obesity in humans, but further research is needed before introducing such dietary therapy.

The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes

2010 ◽  
Vol 1 (4) ◽  
pp. 433-437 ◽  
Author(s):  
H. Roelofsen ◽  
M. Priebe ◽  
R. Vonk
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Physiological Relevance ◽  
Anti Inflammatory ◽  
Chain Fatty Acids

Short chain fatty acids (SCFA) are the main bacterial metabolites of colonic fermentation processes. The physiological relevance of the SCFA for the host outside the gastrointestinal tract is getting increased attention. In this review we will focus on the effect of SCFA on inflammation processes in the host in relation to insulin resistance. Obesity has been associated with a pro-inflammatory state of the adipose tissue that is associated with whole body insulin resistance leading to type 2 diabetes. Recently, two G protein-coupled receptors (GPCR) for SCFA, GPCR 41 and GPCR43, were described that are mainly expressed by immune cells but also by adipose tissue. Propionate can induce the satiety hormone leptin and reduce expression of inflammatory cytokines and chemokines indicating that SCFA have anti-inflammatory effects in human adipose tissue. In addition, in human nutritional experiments we observed that whole grain products could counteract a glucose-induced tumour necrosis factor α and interleukin-6 increase which was associated with increased plasma butyrate concentrations. This suggests that dietary fibre can produce a SCFA profile that could have anti-inflammatory effects in the body. The physiological relevance of these observations especially in relation to obesity-associated inflammation and insulin resistance is discussed.

scholarly journals The Interaction of Short-Chain Fatty Acids (SCFA) With Adipose Tissue; Relevance for Systemic Inflammation

2011 ◽  
Vol 140 (5) ◽  
pp. S-860 ◽  
Author(s):  
Roel J. Vonk ◽  
Marion Priebe ◽  
Kees Meijer ◽  
Koen Venema ◽  
Han Roelofsen
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Systemic Inflammation ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

scholarly journals Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3666
Author(s):  
Karolline S. May ◽  
Laura J. den den Hartigh
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Gut Hormones ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Adipose Tissue Metabolism ◽  
Global Epidemic ◽  
Tissue Metabolism ◽  
Novel Therapeutic Strategies ◽  
Chain Fatty Acids

Obesity and its complications—including type 2 diabetes, cardiovascular disease, and certain cancers—constitute a rising global epidemic that has imposed a substantial burden on health and healthcare systems over the years. It is becoming increasingly clear that there is a link between obesity and the gut microbiota. Gut dysbiosis, characterized as microbial imbalance, has been consistently associated with obesity in both humans and animal models, and can be reversed with weight loss. Emerging evidence has shown that microbial-derived metabolites such as short-chain fatty acids (SCFAs)—including acetate, propionate, and butyrate—provide benefits to the host by impacting organs beyond the gut, including adipose tissue. In this review, we summarize what is currently known regarding the specific mechanisms that link gut-microbial-derived SCFAs with adipose tissue metabolism, such as adipogenesis, lipolysis, and inflammation. In addition, we explore indirect mechanisms by which SCFAs can modulate adipose tissue metabolism, such as via perturbation of gut hormones, as well as signaling to the brain and the liver. Understanding how the modulation of gut microbial metabolites such as SCFAs can impact adipose tissue function could lead to novel therapeutic strategies for the prevention and treatment of obesity.

Effect of short-chain fatty acids on the ethylene pathway in embryonic axes of Cicer arietinum during germination

1994 ◽  
Vol 92 (4) ◽  
pp. 629-635 ◽  
Author(s):  
Mercedes Gallardo ◽  
Paloma Munoz De Rueda ◽  
Angel Jesus Matilla ◽  
Isabel Maria Sanchez-Calle
Keyword(s):  
Fatty Acids ◽  
Cicer Arietinum ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Embryonic Axes ◽  
Chain Fatty Acids

Short-Chain Fatty Acids Prevent Diabetic Nephropathy In Vivo and In Vitro

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 92-OR ◽  
Author(s):  
WEI HUANG ◽  
YONG XU ◽  
YOUHUA XU ◽  
LUPING ZHOU ◽  
CHENLIN GAO
Keyword(s):  
Fatty Acids ◽  
Diabetic Nephropathy ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

1898-P: Colonic Short-Chain Fatty Acids Lower Endogenous Glucose Production

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1898-P
Author(s):  
ADELINA I.L. LANE ◽  
SAVANNA N. WENINGER ◽  
FRANK DUCA
Keyword(s):  
Fatty Acids ◽  
Glucose Production ◽  
Short Chain Fatty Acids ◽  
Endogenous Glucose Production ◽  
Short Chain ◽  
Endogenous Glucose ◽  
Chain Fatty Acids

Concentrations and Correlations of Faecal Short-chain Fatty Acids and Faecal Water Content in Man

1994 ◽  
Vol 7 (6) ◽  
Author(s):  
U. Siigur ◽  
K. E. Norin ◽  
G. Allgood ◽  
T. Schlagheck ◽  
Tore Midtvedt
Keyword(s):  
Fatty Acids ◽  
Water Content ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids
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