scholarly journals Nutritional Phenotype Databases and Integrated Nutrition: From Molecules to Populations

2014 ◽  
Vol 5 (3) ◽  
pp. 352S-357S ◽  
Author(s):  
Michael J. Gibney ◽  
Breige A. McNulty ◽  
Miriam F. Ryan ◽  
Marianne C. Walsh
Keyword(s):  
Nutritional Phenotype

scholarly journals Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

2010 ◽  
Vol 5 (3) ◽  
pp. 189-203 ◽  
Author(s):  
Ben van Ommen ◽  
Jildau Bouwman ◽  
Lars O. Dragsted ◽  
Christian A. Drevon ◽  
Ruan Elliott ◽  
...  
Keyword(s):  
Systems Biology ◽  
Nutrition Research ◽  
Nutritional Phenotype

scholarly journals Impact of the Resident Microbiota on the Nutritional Phenotype of Drosophila melanogaster

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36765 ◽  
Author(s):  
Emma V. Ridley ◽  
Adam C-N. Wong ◽  
Stephanie Westmiller ◽  
Angela E. Douglas
Keyword(s):  
Drosophila Melanogaster ◽  
Nutritional Phenotype

scholarly journals Colonization with heterologous bacteria reprograms a Caenorhabditis elegans nutritional phenotype

2020 ◽  
Author(s):  
Qing Sun ◽  
Nicole M. Vega ◽  
Bernardo Cervantes ◽  
Christopher P. Mancuso ◽  
Ning Mao ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Gut Microbiome ◽  
Bacterial Species ◽  
Model System ◽  
Cellulolytic Bacteria ◽  
Nutrient Sources ◽  
Host Interactions ◽  
C Elegans ◽  
Nutritional Benefits ◽  
Nutritional Phenotype

AbstractAnimals rely on the gut microbiome to process complex food compounds that the host cannot digest and to synthesize nutrients that the host cannot produce. New systems are needed to study how the expanded metabolic capacity provided by the gut microbiome impacts the nutritional status and health of the host. Here we colonized the nematode Caenorhabditis elegans gut with cellulolytic bacteria that enabled C. elegans to utilize cellulose, an otherwise indigestible substrate, as a carbon source. The nutritional benefits of colonization with cellulolytic bacteria were assayed directly, by incorporation of isotopic biomass, and indirectly, as host larval yield resulting from glucose release in the gut. As a community component in the worm gut, cellulolytic bacteria can also support additional bacterial species with specialized roles, which we demonstrate by using Lactobacillus to protect against Salmonella infection. As a model system, C. elegans colonized with cellulolytic bacteria can be used to study microbiome-host interactions. Engineered microbiome communities may provide host organisms with novel functions, such as the ability to use more complex nutrient sources and to fight against pathogen infections.One Sentence SummaryHeterologous bacteria colonizing an animal gut help digest complex sugars to provide nutrition for the host in a model system.

Host and symbiont genetic determinants of nutritional phenotype in a natural population of the pea aphid

2020 ◽  
Vol 29 (4) ◽  
pp. 848-858 ◽  
Author(s):  
Seung Ho Chung ◽  
Benjamin J. Parker ◽  
Frances Blow ◽  
Jennifer A. Brisson ◽  
Angela E. Douglas
Keyword(s):  
Natural Population ◽  
Pea Aphid ◽  
Genetic Determinants ◽  
Nutritional Phenotype

scholarly journals The challenges for molecular nutrition research 2: quantification of the nutritional phenotype

2008 ◽  
Vol 3 (2) ◽  
pp. 51-59 ◽  
Author(s):  
Ben van Ommen ◽  
Jaap Keijer ◽  
Robert Kleemann ◽  
Ruan Elliott ◽  
Christian A. Drevon ◽  
...  
Keyword(s):  
Nutrition Research ◽  
Nutritional Phenotype

scholarly journals Host Genetic Control of the Microbiota Mediates the Drosophila Nutritional Phenotype

2015 ◽  
Vol 82 (2) ◽  
pp. 671-679 ◽  
Author(s):  
John M. Chaston ◽  
Adam J. Dobson ◽  
Peter D. Newell ◽  
Angela E. Douglas
Keyword(s):  
Genetic Control ◽  
Genome Wide Association Study ◽  
Taxonomic Composition ◽  
Nutrient Allocation ◽  
Host Genotype ◽  
Content Type ◽  
A Genome ◽  
Allocation Patterns ◽  
Host Genetic ◽  
Nutritional Phenotype

ABSTRACTA wealth of studies has demonstrated that resident microorganisms (microbiota) influence the pattern of nutrient allocation to animal protein and energy stores, but it is unclear how the effects of the microbiota interact with other determinants of animal nutrition, including animal genetic factors and diet. Here, we demonstrate that members of the gut microbiota inDrosophila melanogastermediate the effect of certain animal genetic determinants on an important nutritional trait, triglyceride (lipid) content. Parallel analysis of the taxonomic composition of the associated bacterial community and host nutritional indices (glucose, glycogen, triglyceride, and protein contents) in multipleDrosophilagenotypes revealed significant associations between the abundance of certain microbial taxa, especiallyAcetobacteraceaeandXanthamonadaceae, and host nutritional phenotype. By a genome-wide association study ofDrosophilalines colonized with a defined microbiota, multiple host genes were statistically associated with the abundance of one bacterium,Acetobacter tropicalis. Experiments using mutantDrosophilavalidated the genetic association evidence and reveal that host genetic control of microbiota abundance affects the nutritional status of the flies. These data indicate that the abundance of the resident microbiota is influenced by host genotype, with consequent effects on nutrient allocation patterns, demonstrating that host genetic control of the microbiome contributes to the genotype-phenotype relationship of the animal host.

scholarly journals The Nutritional Phenotype in the Age of Metabolomics

2005 ◽  
Vol 135 (7) ◽  
pp. 1613-1616 ◽  
Author(s):  
S. H. Zeisel ◽  
H. C. Freake ◽  
D. E. Bauman ◽  
D. M. Bier ◽  
D. G. Burrin ◽  
...  
Keyword(s):  
Nutritional Phenotype
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