scholarly journals Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles

2008 ◽  
Vol 89 (1) ◽  
pp. 51-57 ◽  
Author(s):  
David M Mutch ◽  
Joan Tordjman ◽  
Véronique Pelloux ◽  
Blaise Hanczar ◽  
Corneliu Henegar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Surgical Biopsy ◽  
Adipose Tissue Gene Expression ◽  
Tissue Gene Expression

Microarray analysis of adipose tissue gene expression profiles between two chicken breeds

2006 ◽  
Vol 31 (5) ◽  
pp. 565-573 ◽  
Author(s):  
Hongbao Wang ◽  
Hui Li ◽  
Qigui Wang ◽  
Yuxiang Wang ◽  
Huabin Han ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Microarray Analysis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Chicken Breeds ◽  
Adipose Tissue Gene Expression ◽  
Tissue Gene Expression

Adipose tissue gene expression profiles in ob/ob mice treated with leptin

Life Sciences ◽  
2008 ◽  
Vol 83 (1-2) ◽  
pp. 35-42 ◽  
Author(s):  
Wei Zhang ◽  
Mary Anne Della-Fera ◽  
Diane L. Hartzell ◽  
Dorothy Hausman ◽  
Clifton A. Baile
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Adipose Tissue Gene Expression ◽  
Tissue Gene Expression

Adipose tissue gene expression profiles of healthy young adult and geriatric dogs

2009 ◽  
Vol 63 (2) ◽  
pp. 160-171 ◽  
Author(s):  
Kelly S. Swanson ◽  
Katherine R. Belsito ◽  
Brittany M. Vester ◽  
Lawrence B. Schook
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Young Adult ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Healthy Young Adult ◽  
Adipose Tissue Gene Expression ◽  
Tissue Gene Expression

scholarly journals Differences in Muscle and Adipose Tissue Gene Expression and Cardio-Metabolic Risk Factors in the Members of Physical Activity Discordant Twin Pairs

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12609 ◽  
Author(s):  
Tuija Leskinen ◽  
Rita Rinnankoski-Tuikka ◽  
Mirva Rintala ◽  
Tuulikki Seppänen-Laakso ◽  
Eija Pöllänen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Risk Factors ◽  
Adipose Tissue ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Adipose Tissue Gene Expression ◽  
Tissue Gene Expression ◽  
Discordant Twin

Central injection of oxytocin reduces food intake and affects hypothalamic and adipose tissue gene expression in chickens

2019 ◽  
Vol 67 ◽  
pp. 11-20
Author(s):  
Betty R. McConn ◽  
Anna Koskinen ◽  
D. Michael Denbow ◽  
Elizabeth R. Gilbert ◽  
Paul B. Siegel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Food Intake ◽  
Adipose Tissue Gene Expression ◽  
Tissue Gene Expression

scholarly journals Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats

2005 ◽  
Vol 34 (2) ◽  
pp. 299-315 ◽  
Author(s):  
Young Ho Suh ◽  
Younyoung Kim ◽  
Jeong Hyun Bang ◽  
Kyoung Suk Choi ◽  
June Woo Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Zucker Diabetic Fatty Rats ◽  
Zdf Rats

Insulin resistance occurs early in the disease process, preceding the development of type 2 diabetes. Therefore, the identification of molecules that contribute to insulin resistance and leading up to type 2 diabetes is important to elucidate the molecular pathogenesis of the disease. To this end, we characterized gene expression profiles from insulin-sensitive tissues, including adipose tissue, skeletal muscle, and liver tissue of Zucker diabetic fatty (ZDF) rats, a well characterized type 2 diabetes animal model. Gene expression profiles from ZDF rats at 6 weeks (pre-diabetes), 12 weeks (diabetes), and 20 weeks (late-stage diabetes) were compared with age- and sex-matched Zucker lean control (ZLC) rats using 5000 cDNA chips. Differentially regulated genes demonstrating > 1.3-fold change at age were identified and categorized through hierarchical clustering analysis. Our results showed that while expression of lipolytic genes was elevated in adipose tissue of diabetic ZDF rats at 12 weeks of age, expression of lipogenic genes was decreased in liver but increased in skeletal muscle of 12 week old diabetic ZDF rats. These results suggest that impairment of hepatic lipogenesis accompanied with the reduced lipogenesis of adipose tissue may contribute to development of diabetes in ZDF rats by increasing lipogenesis in skeletal muscle. Moreover, expression of antioxidant defense genes was decreased in the liver of 12-week old diabetic ZDF rats as well as in the adipose tissue of ZDF rats both at 6 and 12 weeks of age. Cytochrome P450 (CYP) genes were also significantly reduced in 12 week old diabetic liver of ZDF rats. Genes involved in glucose utilization were downregulated in skeletal muscle of diabetic ZDF rats, and the hepatic gluconeogenic gene was upregulated in diabetic ZDF rats. Genes commonly expressed in all three tissue types were also observed. These profilings might provide better fundamental understanding of insulin resistance and development of type 2 diabetes.

The characteristics of mesenteric adipose tissue attached to different intestinal segments and their roles in immune regulation

2022 ◽  
Author(s):  
Haowei Zhang ◽  
Yujin Ding ◽  
Qin Zeng ◽  
Dandan Wang ◽  
Ganglei Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Immune Regulation ◽  
Expression Profiles ◽  
Critical Role ◽  
Gene Expression Profiles ◽  
Rna Seq ◽  
Mesenteric Adipose Tissue ◽  
Cell Components ◽  
Subsequent Effect

Background: Mesenteric adipose tissue (MAT) plays a critical role in the intestinal physiological ecosystems. Small and large intestines have evidently intrinsic and distinct characteristics. However, whether there exist any mesenteric differences adjacent to the small and large intestines (SMAT and LMAT) has not been properly characterized. We studied the important facets of these differences, such as morphology, gene expression, cell components and immune regulation of MATs, to characterize the mesenteric differences. Methods: The SMAT and LMAT of mice were utilized for comparison of tissue morphology. Paired mesenteric samples were analyzed by RNA-seq to clarify gene expression profiles. MAT partial excision models were constructed to illustrate the immune regulation roles of MATs, and 16S-seq was applied to detect the subsequent effect on microbiota. Results: Our data show that different segments of mesenteries have different morphological structures. SMAT not only has smaller adipocytes but also contains more fat-associated lymphoid clusters than LMAT. The gene expression profile is also discrepant between these two MATs in mice. B-cell markers were abundantly expressed in SMAT, while development-related genes were highly expressed in LMAT. Adipose-derived stem cells of LMAT exhibited higher adipogenic potential and lower proliferation rates than those of SMAT. In addition, SMAT and LMAT play different roles in immune regulation and subsequently affect microbiota components. Finally, our data clarified the described differences between SMAT and LMAT in humans. Conclusions: There were significant differences in cell morphology, gene expression profiles, cell components, biological characteristics, and immune and microbiota regulation roles between regional MATs.

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