scholarly journals Prospective analysis of surgical outcomes in patients undergoing decompressive laminectomy and posterior instrumentation for degenerative lumbar spinal stenosis

2010 ◽  
pp. 235-240 ◽  
Author(s):  
Ioannis Gelalis
Keyword(s):  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Surgical Outcomes ◽  
Posterior Instrumentation ◽  
Prospective Analysis ◽  
Decompressive Laminectomy ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal

scholarly journals Indications for fusion following decompression for lumbar spinal stenosis

1997 ◽  
Vol 3 (2) ◽  
pp. E4 ◽  
Author(s):  
Mark W. Fox ◽  
Burton M. Onofrio
Keyword(s):  
Clinical Outcomes ◽  
Elderly People ◽  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Decompressive Surgery ◽  
Common Condition ◽  
Decompressive Laminectomy ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal ◽  
Better Than

Degenerative lumbar spinal stenosis is a common condition affecting middle-aged and elderly people. Significant controversy exists concerning the appropriate indications for fusion following decompressive surgery. The purpose of this report is to compare the clinical outcomes of patients who were and were not treated with fusion following decompressive laminectomy for spinal stenosis and to identify whether fusion was beneficial. The authors conclude that patients in whom concomitant fusion procedures were performed fared better than patients who were treated by means of decompression alone when evidence of radiological instability existed preoperatively.

Minimum 10-Year Outcome of Decompressive Laminectomy for Degenerative Lumbar Spinal Stenosis

Spine ◽  
2000 ◽  
Vol 25 (14) ◽  
pp. 1754-1759 ◽  
Author(s):  
Tetsuhiro Iguchi ◽  
Akira Kurihara ◽  
Junichi Nakayama ◽  
Keizou Sato ◽  
Masahiro Kurosaka ◽  
...  
Keyword(s):  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Decompressive Laminectomy ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal

scholarly journals The identification of novel gene mutations for degenerative lumbar spinal stenosis using whole-exome sequencing in a Chinese cohort

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Xin Jiang ◽  
Dong Chen
Keyword(s):  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Gene Mutations ◽  
Specific Gene ◽  
Single Nucleotide ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Whole Exome ◽  
Lumbar Spinal

Abstract Background Degenerative lumbar spinal stenosis (DLSS) is a common lumbar disease that requires surgery. Previous studies have indicated that genetic mutations are implicated in DLSS. However, studies on specific gene mutations are scarce. Whole-exome sequencing (WES) is a valuable research tool that identifies disease-causing genes and could become an effective strategy to investigate DLSS pathogenesis. Methods From January 2016 to December 2017, we recruited 50 unrelated patients with symptoms consistent with DLSS and 25 unrelated healthy controls. We conducted WES and exome data analysis to identify susceptible genes. Allele mutations firstly identified potential DLSS variants in controls to the patients’ group. We conducted a site-based association analysis to identify pathogenic variants using PolyPhen2, SIFT, Mutation Taster, Combined Annotation Dependent Depletion, and Phenolyzer algorithms. Potential variants were further confirmed using manual curation and validated using Sanger sequencing. Results In this cohort, the major classification variant was missense_mutation, the major variant type was single nucleotide polymorphism (SNP), and the major single nucleotide variation was C > T. Multiple SNPs in 34 genes were identified when filtered allele mutations in controls to retain only patient mutations. Pathway enrichment analyses revealed that mutated genes were mainly enriched for immune response-related signaling pathways. Using the Novegene database, site-based associations revealed several novel variants, including HLA-DRB1, PARK2, ACTR8, AOAH, BCORL1, MKRN2, NRG4, NUP205 genes, etc., were DLSS related. Conclusions Our study revealed that deleterious mutations in several genes might contribute to DLSS etiology. By screening and confirming susceptibility genes using WES, we provided more information on disease pathogenesis. Further WES studies incorporating larger DLSS patient cohorts are required to comprehend the genetic landscape of DLSS pathophysiology fully.

scholarly journals Severity of degenerative lumbar spinal stenosis affects pelvic rigidity during walking

2020 ◽  
Vol 20 (1) ◽  
pp. 112-120 ◽  
Author(s):  
Helen Bumann ◽  
Corina Nüesch ◽  
Stefan Loske ◽  
S. Kimberly Byrnes ◽  
Balázs Kovacs ◽  
...  
Keyword(s):  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal

scholarly journals Influence of Skeletal Muscle Mass and Spinal Alignment on Surgical Outcomes for Lumbar Spinal Stenosis

2018 ◽  
Vol 12 (3) ◽  
pp. 556-562 ◽  
Author(s):  
Yawara Eguchi ◽  
Munetaka Suzuki ◽  
Hajime Yamanaka ◽  
Hiroshi Tamai ◽  
Tatsuya Kobayashi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Surgical Outcomes ◽  
Skeletal Muscle Mass ◽  
Spinal Alignment ◽  
Lumbar Spinal

Computed tomography in degenerative lumbar spinal stenosis: The value of multiplanar reconstruction

Radiographics ◽  
1982 ◽  
Vol 2 (4) ◽  
pp. 529-551 ◽  
Author(s):  
Paul C. McAfee ◽  
Christopher G. Ullrich ◽  
E. Mark Levinsohn ◽  
Hansen A. Yuan ◽  
Edwin D. Cacayorin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Multiplanar Reconstruction ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal
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