Contrast Agents For Magnetic Resonance Imaging Based On Ferrite Nanoparticles Synthesized by Using a Wet-Chemical Method

2008 ◽  
Vol 53 (2) ◽  
pp. 772-775 ◽  
Author(s):  
Tran Hoang Hai ◽  
Le Hong Phuc ◽  
Doan Thi Kim Dung ◽  
Nguyen Thi Le Huyen ◽  
Bui Duc Long ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Chemical Method ◽  
Ferrite Nanoparticles ◽  
Resonance Imaging ◽  
Wet Chemical Method ◽  
Wet Chemical

scholarly journals Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

2021 ◽  
pp. 2101019
Author(s):  
Sandra Díez‐Villares ◽  
Miguel A. Ramos‐Docampo ◽  
Andrés da Silva‐Candal ◽  
Pablo Hervella ◽  
Abi J. Vázquez‐Ríos ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Vitamin E ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Ferrite Nanoparticles ◽  
Manganese Ferrite ◽  
Resonance Imaging

scholarly journals Magnetic Nanoparticles for Early Detection of Cancer by Magnetic Resonance Imaging

MRS Bulletin ◽  
2009 ◽  
Vol 34 (6) ◽  
pp. 441-448 ◽  
Author(s):  
Wenbin Lin ◽  
Taeghwan Hyeon ◽  
Gregory M. Lanza ◽  
Miqin Zhang ◽  
Thomas J. Meade
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Early Detection ◽  
Contrast Agents ◽  
Contrast Enhancement ◽  
Negative Contrast ◽  
Mri Contrast Agents ◽  
Ferrite Nanoparticles ◽  
Resonance Imaging

AbstractThis article provides a brief overview of recent progress in the synthesis and functionalization of magnetic nanoparticles and their applications in the early detection of malignant tumors by magnetic resonance imaging (MRI). The intrinsic low sensitivity of MRI necessitates the use of large quantities of exogenous contrast agents in many imaging studies. Magnetic nanoparticles have recently emerged as highly efficient MRI contrast agents because these nanometer-scale materials can carry high payloads while maintaining the ability to move through physiological systems. Superparamagnetic ferrite nanoparticles (such as iron oxide) provide excellent negative contrast enhancement. Recent refinement of synthetic methodologies has led to ferrite nanoparticles with narrow size distributions and high crystallinity. Target-specific tumor imaging becomes possible through functionalization of ferrite nanoparticles with targeting agents to allow for site-specific accumulation. Nanoparticulate contrast agents capable of positive contrast enhancement have recently been developed in order to overcome the drawbacks of negative contrast enhancement afforded by ferrite nanoparticles. These newly developed magnetic nanoparticles have the potential to enable physicians to diagnose cancer at the earliest stage possible and thus can have an enormous impact on more effective cancer treatment.

Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Tobacco Mosaic Virus ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Physiological Conditions

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

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