scholarly journals Automated knowledge-assisted mitosis cells detection framework in breast histopathology images

2021 ◽  
Vol 19 (2) ◽  
pp. 1720-1744
Author(s):  
Xiao Jian Tan ◽  
◽  
Nazahah Mustafa ◽  
Mohd Yusoff Mashor ◽  
Khairul Shakir Ab Rahman ◽  
...  
Keyword(s):  
False Positive ◽  
Domain Knowledge ◽  
Reduction Method ◽  
Support Vector ◽  
Svm Classifier ◽  
False Positive Reduction ◽  
Histopathology Images ◽  
Automated Knowledge ◽  
Inconsistent Objects ◽  
Nucleus Segmentation

<abstract> <p>Based on the Nottingham Histopathology Grading (NHG) system, mitosis cells detection is one of the important criteria to determine the grade of breast carcinoma. Mitosis cells detection is a challenging task due to the heterogeneous microenvironment of breast histopathology images. Recognition of complex and inconsistent objects in the medical images could be achieved by incorporating domain knowledge in the field of interest. In this study, the strategies of the histopathologist and domain knowledge approach were used to guide the development of the image processing framework for automated mitosis cells detection in breast histopathology images. The detection framework starts with color normalization and hyperchromatic nucleus segmentation. Then, a knowledge-assisted false positive reduction method is proposed to eliminate the false positive (i.e., non-mitosis cells). This stage aims to minimize the percentage of false positive and thus increase the F1-score. Next, features extraction was performed. The mitosis candidates were classified using a Support Vector Machine (SVM) classifier. For evaluation purposes, the knowledge-assisted detection framework was tested using two datasets: a custom dataset and a publicly available dataset (i.e., MITOS dataset). The proposed knowledge-assisted false positive reduction method was found promising by eliminating at least 87.1% of false positive in both the dataset producing promising results in the F1-score. Experimental results demonstrate that the knowledge-assisted detection framework can achieve promising results in F1-score (custom dataset: 89.1%; MITOS dataset: 88.9%) and outperforms the recent works.</p> </abstract>

scholarly journals Automatic Detection of Voltage Notches using Support Vector Machine

2021 ◽  
Vol 19 ◽  
pp. 528-533
Author(s):  
Rongzhen Qi ◽  
◽  
Olga Zyabkina ◽  
Daniel Agudelo Martinez ◽  
Jan Meyer
Keyword(s):  
Support Vector Machine ◽  
Domain Knowledge ◽  
Detection Efficiency ◽  
Support Vector ◽  
Svm Classifier ◽  
Automatic Method ◽  
Power Quality Disturbances ◽  
Characteristic Features ◽  
Comprehensive Framework ◽  
Nonlinear Support

This paper presents a comprehensive framework for voltage notch analysis and an automatic method for notch detection using a nonlinear support vector machine (SVM) classifier. A comprehensive simulation of the notch disturbance has been conducted to generate a diverse database. Based on domain knowledge and properties of power quality disturbances (PQDs), a set of characteristic features is extracted. After feature extraction, a set of most descriptive features has been selected with decision tree (DT) algorithm, and a nonlinear SVM classifier has been trained. Finally, the detection efficiency of the trained model is presented and discussed.

Deep-learning and radiomics ensemble classifier for false positive reduction in brain metastases segmentation

2021 ◽  
Author(s):  
Zi Yang ◽  
Mingli Chen ◽  
Mahdieh Kazemimoghadam ◽  
Lin Ma ◽  
Strahinja Stojadinovic ◽  
...  
Keyword(s):  
Deep Learning ◽  
Brain Metastases ◽  
False Positive ◽  
False Positive Rate ◽  
Ensemble Classifier ◽  
Support Vector ◽  
Svm Classifier ◽  
Siamese Network ◽  
Proposed Model ◽  
Positive Rate

Abstract Stereotactic radiosurgery (SRS) is now the standard of care for brain metastases (BMs) patients. The SRS treatment planning process requires precise target delineation, which in clinical workflow for patients with multiple (>4) BMs (mBMs) could become a pronounced time bottleneck. Our group has developed an automated BMs segmentation platform to assist in this process. The accuracy of the auto-segmentation, however, is influenced by the presence of false-positive segmentations, mainly caused by the injected contrast during MRI acquisition. To address this problem and further improve the segmentation performance, a deep-learning and radiomics ensemble classifier was developed to reduce the false-positive rate in segmentations. The proposed model consists of a Siamese network and a radiomic-based support vector machine (SVM) classifier. The 2D-based Siamese network contains a pair of parallel feature extractors with shared weights followed by a single classifier. This architecture is designed to identify the inter-class difference. On the other hand, the SVM model takes the radiomic features extracted from 3D segmentation volumes as the input for twofold classification, either a false-positive segmentation or a true BM. Lastly, the outputs from both models create an ensemble to generate the final label. The performance of the proposed model in the segmented mBMs testing dataset reached the accuracy (ACC), sensitivity (SEN), specificity (SPE) and area under the curve (AUC) of 0.91, 0.96, 0.90 and 0.93, respectively. After integrating the proposed model into the original segmentation platform, the average segmentation false negative rate (FNR) and the false positive over the union (FPoU) were 0.13 and 0.09, respectively, which preserved the initial FNR (0.07) and significantly improved the FPoU (0.55). The proposed method effectively reduced the false-positive rate in the BMs raw segmentations indicating that the integration of the proposed ensemble classifier into the BMs segmentation platform provides a beneficial tool for mBMs SRS management.

scholarly journals A Novel Embedded Feature Selection and Dimensionality Reduction Method for an SVM Type Classifier to Predict Periventricular Leukomalacia (PVL) in Neonates

2021 ◽  
Vol 11 (23) ◽  
pp. 11156
Author(s):  
Dieter Bender ◽  
Daniel J. Licht ◽  
C. Nataraj
Keyword(s):  
Heart Surgery ◽  
Reduction Method ◽  
Periventricular Leukomalacia ◽  
Support Vector ◽  
Svm Classifier ◽  
Algorithm Optimization ◽  
Learning Framework ◽  
Svm Model ◽  
Testing Accuracy ◽  
Dimensionality Reduction Method

This paper is concerned with the prediction of the occurrence of periventricular leukomalacia (PVL) in neonates after heart surgery. Our prior work shows that the Support Vector Machine (SVM) classifier can be a powerful tool in predicting clinical outcomes of such complicated and uncommon diseases, even when the number of data samples is low. In the presented work, we first illustrate and discuss the shortcomings of the traditional automatic machine learning (aML) approach. Consequently, we describe our methodology for addressing these shortcomings, while utilizing the designed interactive ML (iML) algorithm. Finally, we conclude with a discussion of the developed method and the results obtained. In sum, by adding an additional (Genetic Algorithm) optimization step in the SVM learning framework, we were able to (a) reduce the dimensionality of an SVM model from 248 to 53 features, (b) increase generalization that was confirmed by a 100% accuracy assessed on an unseen testing set, and (c) improve the overall SVM model’s performance from 65% to 100% testing accuracy, utilizing the proposed iML method.

scholarly journals A Transfer Learning Architecture Based on a Support Vector Machine for Histopathology Image Classification

2021 ◽  
Vol 11 (14) ◽  
pp. 6380
Author(s):  
Jiayi Fan ◽  
JangHyeon Lee ◽  
YongKeun Lee
Keyword(s):  
Support Vector Machine ◽  
Transfer Learning ◽  
Classification Accuracy ◽  
Support Vector ◽  
Svm Classifier ◽  
Breast Cancer Dataset ◽  
Classification Problems ◽  
Cancer Dataset ◽  
Softmax Classifier ◽  
Histopathology Images

Recently, digital pathology is an essential application for clinical practice and medical research. Due to the lack of large annotated datasets, the deep transfer learning technique is often used to classify histopathology images. A softmax classifier is often used to perform classification tasks. Besides, a Support Vector Machine (SVM) classifier is also popularly employed, especially for binary classification problems. Accurately determining the category of the histopathology images is vital for the diagnosis of diseases. In this paper, the conventional softmax classifier and the SVM classifier-based transfer learning approach are evaluated to classify histopathology cancer images in a binary breast cancer dataset and a multiclass lung and colon cancer dataset. In order to achieve better classification accuracy, a methodology that attaches SVM classifier to the fully-connected (FC) layer of the softmax-based transfer learning model is proposed. The proposed architecture involves a first step training the newly added FC layer on the target dataset using the softmax-based model and a second step training the SVM classifier with the newly trained FC layer. Cross-validation is used to ensure no bias for the evaluation of the performance of the models. Experimental results reveal that the conventional SVM classifier-based model is the least accurate on either binary or multiclass cancer datasets. The conventional softmax-based model shows moderate classification accuracy, while the proposed synthetic architecture achieves the best classification accuracy.

scholarly journals Tutorial on Support Vector Machines

2022 ◽  
Author(s):  
Raj Bridgelall
Keyword(s):  
Support Vector Machines ◽  
Domain Knowledge ◽  
Instructional Materials ◽  
Classification Model ◽  
Support Vector ◽  
Svm Classifier ◽  
Practical Applications ◽  
Vector Machines ◽  
And Performance ◽  
Beginning Students

Abstract The aim of this tutorial is to help students grasp the theory and applicability of support vector machines (SVMs). The contribution is an intuitive style tutorial that helped students gain insights into SVM from a unique perspective. An internet search will reveal many videos and articles on SVM, but free peer-reviewed tutorials are generally not available or are incomplete. Instructional materials that provide simplified explanations of SVM leave gaps in the derivations that beginning students cannot fill. Most of the free tutorials also lack guidance on practical applications and considerations. The software wrappers in many modern programming libraries of Python and R currently hide the operational complexities. Such software tools often use default parameters that ignore domain knowledge or leave knowledge gaps about the important effects of SVM hyperparameters, resulting in misuse and subpar outcomes. The author uses this tutorial as a course reference for students studying artificial intelligence and machine learning. The tutorial derives the classic SVM classifier from first principles and then derives the practical form that a computer uses to train a classification model. An intuitive explanation about confusion matrices, F1 score, and the AUC metric extend insights into the inherent tradeoff between sensitivity and specificity. A discussion about cross-validation provides a basic understanding of how to select and tune the hyperparameters to maximize generalization by balancing underfitting and overfitting. Even seasoned self-learners with advanced statistical backgrounds have gained insights from this tutorial style of intuitive explanations, with all related considerations for tuning and performance evaluations in one place.

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