scholarly journals Stability and bifurcation analysis of a tumor-immune system with two delays and diffusion

2021 ◽  
Vol 19 (2) ◽  
pp. 1154-1173
Author(s):  
Yuting Ding ◽  
◽  
Gaoyang Liu ◽  
Yong An
Keyword(s):  
Immune System ◽  
Hopf Bifurcation ◽  
Tumor Cells ◽  
Multiple Time Scales ◽  
Multiple Time ◽  
Asymptotically Stable ◽  
Two Delays ◽  
The Stability ◽  
The Impact ◽  
And Diffusion

<abstract><p>A tumor-immune system with diffusion and delays is proposed in this paper. First, we investigate the impact of delay on the stability of nonnegative equilibrium for the model with a single delay, and the system undergoes Hopf bifurcation when delay passes through some critical values. We obtain the normal form of Hopf bifurcation by applying the multiple time scales method for determining the stability and direction of bifurcating periodic solutions. Then, we study the tumor-immune model with two delays, and show the conditions under which the nontrivial equilibria are locally asymptotically stable. Thus, we can restrain the diffusion of tumor cells by controlling the time delay associated with the time of tumor cell proliferation and the time of immune cells recognizing tumor cells. Finally, numerical simulations are presented to illustrate our analytic results.</p></abstract>

BIFURCATION AND SPATIOTEMPORAL PATTERNS IN A HOMOGENEOUS DIFFUSION-COMPETITION SYSTEM WITH DELAYS

2012 ◽  
Vol 05 (06) ◽  
pp. 1250049 ◽  
Author(s):  
JIA-FANG ZHANG ◽  
WAN-TONG LI ◽  
XIANG-PING YAN
Keyword(s):  
Hopf Bifurcation ◽  
Neumann Boundary ◽  
Reaction Diffusion ◽  
Hopf Bifurcations ◽  
Asymptotically Stable ◽  
Interspecies Competition ◽  
Globally Asymptotically Stable ◽  
Two Delays ◽  
Delayed System ◽  
The Stability

A competitive Lotka–Volterra reaction-diffusion system with two delays subject to Neumann boundary conditions is considered. It is well known that the positive constant steady state of the system is globally asymptotically stable if the interspecies competition is weaker than the intraspecies one and is unstable if the interspecies competition dominates over the intraspecies one. If the latter holds, then we show that Hopf bifurcation can occur as the parameters (delays) in the system cross some critical values. In particular, we prove that these Hopf bifurcations are all spatially homogeneous if the diffusive rates are suitably large, which has the same properties as Hopf bifurcation of the corresponding delayed system without diffusion. However, if the diffusive rates are suitably small, then the system generates the spatially nonhomogeneous Hopf bifurcation. Furthermore, we derive conditions for determining the direction of spatially nonhomogeneous Hopf bifurcations and the stability of bifurcating periodic solutions. These results indicate that the diffusion plays an important role for deriving the complex spatiotemporal dynamics.

Numerical Approximation of Hopf Bifurcation for Tumor-Immune System Competition Model with Two Delays

2013 ◽  
Vol 5 (2) ◽  
pp. 146-162
Author(s):  
Jing-Jun Zhao ◽  
Jing-Yu Xiao ◽  
Yang Xu
Keyword(s):  
Immune System ◽  
Hopf Bifurcation ◽  
Numerical Approximation ◽  
Center Manifold ◽  
Competition Model ◽  
Center Manifold Theory ◽  
Two Delays ◽  
Normal Form Method ◽  
The Stability ◽  
Manifold Theory

AbstractThis paper is concerned with the Hopf bifurcation analysis of tumor-immune system competition model with two delays. First, we discuss the stability of state points with different kinds of delays. Then, a sufficient condition to the existence of the Hopf bifurcation is derived with parameters at different points. Furthermore, under this condition, the stability and direction of bifurcation are determined by applying the normal form method and the center manifold theory. Finally, a kind of Runge-Kutta methods is given out to simulate the periodic solutions numerically. At last, some numerical experiments are given to match well with the main conclusion of this paper.

scholarly journals Dynamical Analysis of a Viral Infection Model with Delays in Computer Networks

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Zizhen Zhang ◽  
Huizhong Yang
Keyword(s):  
Hopf Bifurcation ◽  
Propagation Model ◽  
Dynamical Analysis ◽  
Infection Model ◽  
Virus Propagation ◽  
Normal Form Theory ◽  
Center Manifold Theorem ◽  
Form Theory ◽  
Two Delays ◽  
The Stability

This paper is devoted to the study of an SIRS computer virus propagation model with two delays and multistate antivirus measures. We demonstrate that the system loses its stability and a Hopf bifurcation occurs when the delay passes through the corresponding critical value by choosing the possible combination of the two delays as the bifurcation parameter. Moreover, the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are determined by means of the center manifold theorem and the normal form theory. Finally, some numerical simulations are performed to illustrate the obtained results.

Hopf Bifurcation Induced by Delay Effect in a Diffusive Tumor-Immune System

2018 ◽  
Vol 28 (11) ◽  
pp. 1850136 ◽  
Author(s):  
Ben Niu ◽  
Yuxiao Guo ◽  
Yanfei Du
Keyword(s):  
Immune System ◽  
Hopf Bifurcation ◽  
Periodic Solutions ◽  
Center Manifold ◽  
Immune Cell ◽  
Tumor Treatment ◽  
Delay Effect ◽  
Stable Periodic ◽  
The Stability ◽  
Bifurcation And Stability

Tumor-immune interaction plays an important role in the tumor treatment. We analyze the stability of steady states in a diffusive tumor-immune model with response and proliferation delay [Formula: see text] of immune system where the immune cell has a probability [Formula: see text] in killing tumor cells. We find increasing time delay [Formula: see text] destabilizes the positive steady state and induces Hopf bifurcations. The criticality of Hopf bifurcation is investigated by deriving normal forms on the center manifold, then the direction of bifurcation and stability of bifurcating periodic solutions are determined. Using a group of parameters to simulate the system, stable periodic solutions are found near the Hopf bifurcation. The effect of killing probability [Formula: see text] on Hopf bifurcation values is also discussed.

Global Hopf Bifurcation in a Phytoplankton–Zooplankton System with Delay and Diffusion

2021 ◽  
Vol 31 (08) ◽  
pp. 2150114
Author(s):  
Ming Liu ◽  
Jun Cao ◽  
Xiaofeng Xu
Keyword(s):  
Hopf Bifurcation ◽  
Global Existence ◽  
Upper And Lower Solutions ◽  
Positive Periodic Solutions ◽  
Global Hopf Bifurcation ◽  
System With Delay ◽  
Local Hopf Bifurcation ◽  
Distribution Of Eigenvalues ◽  
The Stability ◽  
And Diffusion

In this paper, the dynamics of a phytoplankton–zooplankton system with delay and diffusion are investigated. The positivity and persistence are studied by using the comparison theorem and upper and lower solutions method. The stability of steady states and the existence of local Hopf bifurcation are obtained by analyzing the distribution of eigenvalues. And the global existence of positive periodic solutions is established by using the global Hopf bifurcation result given by Wu [1996]. Finally, some numerical simulations are carried out to illustrate the analytical results.

Time-scale dependent mechanism of atmospheric CO2 concentration drivers of watershed water-energy balance

2021 ◽  
Author(s):  
Jing Zhao
Keyword(s):  
Energy Balance ◽  
River Basin ◽  
Time Scales ◽  
Time Scale ◽  
Hydrological Processes ◽  
Multiple Time Scales ◽  
Multiple Time ◽  
The Wei River Basin ◽  
Balance Dynamics ◽  
The Impact

&lt;p&gt;The elevated atmospheric carbon dioxide concentration (CO&lt;sub&gt;2&lt;/sub&gt;), as a key variable linking human activities and climate change, seriously affects the watershed hydrological processes. However, whether and how atmospheric CO&lt;sub&gt;2&lt;/sub&gt; influences the watershed water-energy balance dynamics at multiple time scales have not been revealed. Based on long-term hydrometeorological data, the variation of non-stationary parameter n series in the Choudhury's equation in the mainstream of the Wei River Basin (WRB), the Jing River Basin (JRB) and Beiluo River Basin (BLRB), three typical Loess Plateau regions in China, was examined. Subsequently, the Empirical Mode Decomposition method was applied to explore the impact of CO&lt;sub&gt;2&lt;/sub&gt; on watershed water-energy balance dynamics at multiple time scales. Results indicate that (1) in the context of warming and drying condition, annual n series in the WRB displays a significantly increasing trend, while that in the JRB and BLRB presents non-significantly decreasing trends; (2) the non-stationary n series was divided into 3-, 7-, 18-, exceeding 18-year time scale oscillations and a trend residual. In the WRB and BLRB, the overall variation of n was dominated by the residual, whereas in the JRB it was dominated by the 7-year time scale oscillation; (3) the relationship between CO&lt;sub&gt;2&amp;#160;&lt;/sub&gt;concentration and n series was significant in the WRB except for 3-year time scale. In the JRB, CO&lt;sub&gt;2&amp;#160;&lt;/sub&gt;concentration and n series were significantly correlated on the 7- and exceeding 7-year time scales, while in the BLRB, such a significant relationship existed only on the 18- and exceeding 18-year time scales. (4) CO&lt;sub&gt;2&lt;/sub&gt;-driven temperature rise and vegetation greening elevated the aridity index and evaporation ratio, thus impacting watershed water-energy balance dynamics. This study provided a deeper explanation for the possible impact of CO&lt;sub&gt;2&lt;/sub&gt; concentration on the watershed hydrological processes.&lt;/p&gt;

scholarly journals Hopf Bifurcation Analysis of a Synthetic Drug Transmission Model with Time Delays

Complexity ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Zizhen Zhang ◽  
Fangfang Yang ◽  
Wanjun Xia
Keyword(s):  
Hopf Bifurcation ◽  
Center Manifold ◽  
Sufficient Conditions ◽  
Transmission Model ◽  
Normal Form Theory ◽  
Center Manifold Theorem ◽  
Form Theory ◽  
Two Delays ◽  
Synthetic Drug ◽  
The Stability

This paper is concerned with the Hopf bifurcation of a synthetic drug transmission model with two delays. Firstly, some sufficient conditions of delay-induced bifurcation for such a model are captured by using different combinations of the two delays as the bifurcation parameter. Secondly, based on the center manifold theorem and normal form theory, some sufficient conditions determining properties of the Hopf bifurcation such as the direction and the stability are established. Finally, to underline the effectiveness of the obtained results, some numerical simulations are ultimately addressed.

scholarly journals Hopf Bifurcation and Dynamic Analysis of an Improved Financial System with Two Delays

Complexity ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
G. Kai ◽  
W. Zhang ◽  
Z. Jin ◽  
C. Z. Wang
Keyword(s):  
Nonlinear Dynamics ◽  
Hopf Bifurcation ◽  
Equilibrium Point ◽  
Chaotic System ◽  
Financial System ◽  
Two Delays ◽  
Normal Form Method ◽  
The Stability ◽  
Manifold Theory ◽  
Theoretical Results

The complex chaotic dynamics and multistability of financial system are some important problems in micro- and macroeconomic fields. In this paper, we study the influence of two-delay feedback on the nonlinear dynamics behavior of financial system, considering the linear stability of equilibrium point under the condition of single delay and two delays. The system undergoes Hopf bifurcation near the equilibrium point. The stability and bifurcation directions of Hopf bifurcation are studied by using the normal form method and central manifold theory. The theoretical results are verified by numerical simulation. Furthermore, one feature of the proposed financial chaotic system is that its multistability depends extremely on the memristor initial condition and the system parameters. It is shown that the nonlinear dynamics of financial chaotic system can be significantly changed by changing the values of time delays.

Fear Induced Stabilization in an Intraguild Predation Model

2020 ◽  
Vol 30 (04) ◽  
pp. 2050053
Author(s):  
Mainul Hossain ◽  
Nikhil Pal ◽  
Sudip Samanta ◽  
Joydev Chattopadhyay
Keyword(s):  
Growth Rate ◽  
Hopf Bifurcation ◽  
Intraguild Predation ◽  
Equilibrium Points ◽  
Stable Limit ◽  
Interior Equilibrium ◽  
The Rich ◽  
The Stability ◽  
The Cost ◽  
The Impact

In the present paper, we investigate the impact of fear in an intraguild predation model. We consider that the growth rate of intraguild prey (IG prey) is reduced due to the cost of fear of intraguild predator (IG predator), and the growth rate of basal prey is suppressed due to the cost of fear of both the IG prey and the IG predator. The basic mathematical results such as positively invariant space, boundedness of the solutions, persistence of the system have been investigated. We further analyze the existence and local stability of the biologically feasible equilibrium points, and also study the Hopf-bifurcation analysis of the system with respect to the fear parameter. The direction of Hopf-bifurcation and the stability properties of the periodic solutions have also been investigated. We observe that in the absence of fear, omnivory produces chaos in a three-species food chain system. However, fear can stabilize the chaos thus obtained. We also observe that the system shows bistability behavior between IG prey free equilibrium and IG predator free equilibrium, and bistability between IG prey free equilibrium and interior equilibrium. Furthermore, we observe that for a suitable set of parameter values, the system may exhibit multiple stable limit cycles. We perform extensive numerical simulations to explore the rich dynamics of a simple intraguild predation model with fear effect.

Hopf Bifurcation of a Type of Neuron Model with Multiple Time Delays

2019 ◽  
Vol 29 (12) ◽  
pp. 1950163 ◽  
Author(s):  
Suqi Ma
Keyword(s):  
Hopf Bifurcation ◽  
Parameter Space ◽  
Time Delays ◽  
Neuron Model ◽  
Multiple Time ◽  
Multiple Time Delays ◽  
The Stability ◽  
Geometrical Scheme ◽  
Delay Differential ◽  
Two Parameter

By applying a geometrical scheme developed to tackle the eigenvalue problem of delay differential equations with multiple time delays, Hopf bifurcation of Hopfield neuron model is analyzed in two-parameter space. By the introduction of two new angles, the calculation of imaginary roots is carried out analytically and effectively. By increasing the parameter to cross over the Hopf bifurcation lines, the stability switching direction is confirmed. The method is a useful tool to show the partition of stable and unstable regions in two-parameter space and detect double Hopf bifurcation further. The typified dynamical behaviors based on nearby double Hopf points are analyzed by applying the normal form technique and center manifold method.

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