scholarly journals Mechano-electric effect and a heart assist device in the synergistic model of cardiac function

2020 ◽  
Vol 17 (5) ◽  
pp. 5212-5233
Author(s):  
Eun-jin Kim ◽  
◽  
Massimo Capoccia ◽  
◽  
ASAIO Journal ◽  
2002 ◽  
Vol 48 (2) ◽  
pp. 140
Author(s):  
Kathy A. Miller ◽  
Reynolds M. Delgado ◽  
Timothy J. Myers ◽  
Tehreen Khan ◽  
Igor D. Gregoric ◽  
...  

1983 ◽  
Vol 86 (5) ◽  
pp. 639-645 ◽  
Author(s):  
Daniel M. Rose ◽  
Stephen B. Colvin ◽  
Alfred T. Culliford ◽  
O. Wayne Isom ◽  
Joseph N. Cunningham ◽  
...  

Perfusion ◽  
2000 ◽  
Vol 15 (4) ◽  
pp. 387-396 ◽  
Author(s):  
Thorsen Drews ◽  
Matthias Loebe ◽  
Ewald Hennig ◽  
Friedrich Kaufmann ◽  
Johannes Müller ◽  
...  

2019 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Eun-jin Kim ◽  
Massimo Capoccia

The breakdown of cardiac self-organization leads to heart diseases and failure, the number one cause of death worldwide. The left ventricular pressure–volume relation plays a key role in the diagnosis and treatment of heart diseases. Lumped-parameter models combined with pressure–volume loop analysis are very effective in simulating clinical scenarios with a view to treatment optimization and outcome prediction. Unfortunately, often invoked in this analysis is the traditional, time-varying elastance concept, in which the ratio of the ventricular pressure to its volume is prescribed by a periodic function of time, instead of being calculated consistently according to the change in feedback mechanisms (e.g., the lack or breakdown of self-organization) in heart diseases. Therefore, the application of the time-varying elastance for the analysis of left ventricular assist device (LVAD)–heart interactions has been questioned. We propose a paradigm shift from the time-varying elastance concept to a synergistic model of cardiac function by integrating the mechanical, electric, and chemical activity on microscale sarcomere and macroscale heart levels and investigating the effect of an axial rotary pump on a failing heart. We show that our synergistic model works better than the time-varying elastance model in reproducing LVAD–heart interactions with sufficient accuracy to describe the left ventricular pressure–volume relation.


1989 ◽  
Vol 47 (1) ◽  
pp. 124-129 ◽  
Author(s):  
D.M. Rose ◽  
M. Connolly ◽  
J.N. Cunningham ◽  
F.C. Spencer

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