scholarly journals Global stability analysis of a viral infection model in a critical case

2020 ◽  
Vol 17 (2) ◽  
pp. 1442-1449
Author(s):  
Wei Wang ◽  
◽  
Xiulan Lai ◽  
2016 ◽  
Vol 09 (04) ◽  
pp. 1650056
Author(s):  
Sandip Banerjee ◽  
Ram Keval ◽  
Sunita Gakkhar

A modified mathematical model of hepatitis C viral dynamics has been presented in this paper, which is described by four coupled ordinary differential equations. The aim of this paper is to perform global stability analysis using geometric approach to stability, based on the higher-order generalization of Bendixson’s criterion. The result is also supported numerically. An important epidemiological issue of eradicating hepatitis C virus has been addressed through the global stability analysis.


2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Huaqin Peng ◽  
Zhiming Guo

A viral infection model with saturated incidence rate and viral infection with delay is derived and analyzed; the incidence rate is assumed to be a specific nonlinear formβxv/(1+αv). The existence and uniqueness of equilibrium are proved. The basic reproductive numberR0is given. The model is divided into two cases: with or without delay. In each case, by constructing Lyapunov functionals, necessary and sufficient conditions are given to ensure the global stability of the models.


2018 ◽  
Vol 16 (1) ◽  
pp. 1374-1389
Author(s):  
Eric Ávila-Vales ◽  
Abraham Canul-Pech ◽  
Erika Rivero-Esquivel

AbstractIn this paper, we discussed a infinitely distributed delayed viral infection model with nonlinear immune response and general incidence rate. We proved the existence and uniqueness of the equilibria. By using the Lyapunov functional and LaSalle invariance principle, we obtained the conditions of global stabilities of the infection-free equilibrium, the immune-exhausted equilibrium and the endemic equilibrium. Numerical simulations are given to verify the analytical results.


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