scholarly journals Breast conserving surgery (BCS) with adjuvant radiation therapy showed improved prognosis compared with mastectomy for early staged triple negative breast cancer patients

2020 ◽  
Vol 17 (1) ◽  
pp. 92-104 ◽  
Author(s):  
Shuoer Wang ◽  
◽  
Yidi Sun ◽  
Songjiao Zhao ◽  
Feng Wei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Conserving Surgery ◽  
Adjuvant Radiation ◽  
Breast Cancer Patients ◽  
Adjuvant Radiation Therapy

Adjuvant radiation therapy in young breast cancer patients: current state of the art and evidence-based algorithm

The Breast ◽  
2018 ◽  
Vol 41 ◽  
pp. S15
Author(s):  
Icro Meattini ◽  
Matteo Lambertini ◽  
Isacco Desideri ◽  
Alex De Caluwé ◽  
Orit Kaidar-Person ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
State Of The Art ◽  
Adjuvant Radiation ◽  
Evidence Based ◽  
Breast Cancer Patients ◽  
Adjuvant Radiation Therapy ◽  
Current State ◽  
Young Breast Cancer

Association of fatigue and insomnia with inflammatory cytokine and hematopoetic stem cell levels in breast cancer patients undergoing adjuvant radiation therapy.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12048-e12048
Author(s):  
Fei-Fei Liu ◽  
Willa Wei Shi ◽  
M McCusker ◽  
Madeline Li ◽  
Jie Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Stem Cell ◽  
Cancer Patients ◽  
Inflammatory Cytokine ◽  
Adjuvant Radiation ◽  
Breast Cancer Patients ◽  
Adjuvant Radiation Therapy ◽  
General Fatigue ◽  
Hematopoetic Stem Cell

e12048 Background: Fatigue and insomnia are frequent conditions experienced by breast cancer patients during adjuvant radiation therapy (RT). Our group reported that fatigue correlates with reduced CD34+ circulating hematopoetic stem cell (HSC) levels. Our current study examined the role of inflammatory cytokines in mediating fatigue and insomnia following adjuvant RT. Methods: Phlebotomies were conducted on 148 breast cancer patients undergoing adjuvant RT at five time points: prior to RT (D1), after two (D2) and five (D5) days of treatment, during the final week of RT (Df), and one month post-RT completion (M1). CD34+, CD45+, circulating blood cell (CBC), and 17 inflammatory cytokine levels were assessed. Patients also completed questionnaires at each time point, including the multidimensional fatigue inventory (MIF-21), insomnia severity index (ISI), and hospital anxiety and depression scale (HADS). Results: CD34+, CD45+ and CBC levels decreased during treatment with adjuvant RT, with the lowest levels observed at Df (p<0.001). General fatigue significantly worsened throughout treatment from D1 to Df, returning to baseline at M1, (p<0.001; adjusted for insomnia, depression and anxiety). General fatigue worsened as CD34+ counts, hemoglobin and CBCs increased (p<0.001). Insomnia increased with reduced CD34+, CD45+ and CBCs (p<0.05). TGF-β1, MCP-1, MMP-2, IL-1ra and IFN-α2a cytokine expression varied throughout RT (p<0.01), most significantly at Df. Elevated MCP-1, TNF-RII and TNF-a levels correlated with worsening general fatigue, increased insomnia, and reduced activity and motivation (p<0.001). MMP-2 increased as IL-1ra, CD34+, CD45+ and CBC counts decreased (p<0.001). Further, the 52 patients who received prior adjuvant chemotherapy had elevated levels of fatigue, insomnia and anxiety, which correlated with high HSCs levels. Conclusions: Our findings demonstrate that fatigue and insomnia are associated with reduced HSCs and increased MCP-1, TNF-RII and TNF-a pro-inflammatory cytokines. This examination of the effect of RT on fatigue and insomnia is one of the most comprehensive longitudinal clinical evaluations of its kind.

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