scholarly journals Evaluation of Thyroid Functions, Oxidative Stress and Antioxidants in Egyptian Children with Nephrotic Syndrome

2015 ◽  
Vol 6 (1) ◽  
pp. 9-14
Author(s):  
Saad Mohamed ◽  
Mohamed Zannoun ◽  
Ahmad El-Askary ◽  
Mohamed Abdel-aal ◽  
Yasser Abdelrahma
Keyword(s):  
Oxidative Stress ◽  
Nephrotic Syndrome ◽  
Egyptian Children

Oxidative Stress in Egyptian Children with Autism: Relation to Autoimmunity

2015 ◽  
Vol 30 ◽  
pp. 807
Author(s):  
D. Hewedi ◽  
G. Mostafa ◽  
E.M.A.N. El Hadidi
Keyword(s):  
Oxidative Stress ◽  
Children With Autism ◽  
Egyptian Children

scholarly journals Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
Gokhan Cakirca ◽  
Ahmet Guzelcicek ◽  
Kenan Yilmaz ◽  
Cemal Nas
Keyword(s):  
Oxidative Stress ◽  
Nephrotic Syndrome ◽  
Pediatric Nephrology ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Ischemia Modified Albumin ◽  
Creative Commons ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive

Objective: Growing evidence shows that oxidative stress plays an important role in the development and progression of nephrotic syndrome (NS). In this study, we aimed to examine serum IMA levels as an indicator of oxidative stress in children with steroid-sensitive NS (SSNS) in remission and relapse. Methods: This cross-sectional study was carried out at the Pediatric Nephrology Unit of Sanliurfa Training and Research Hospital, Sanliurfa, Turkey, from April 2019 to December 2019. In this study Serum IMA and albumin levels were determined in 70 children with SSNS and 45 healthy controls. Among the children with SSNS, 50 were in remission and 20 were in relapse. Then, adjusted IMA levels were calculated from the IMA/albumin ratio. Results: IMA and adjusted IMA levels significantly increased and albumin significantly decreased in children with SSNS in relapse and remission compared with those of the healthy controls. Moreover, these alterations were more prominent in the relapse group than in the remission group. IMA was inversely correlated with albumin in children with SSNS (r= −0.881, p= <0.001). Conclusions: Our findings demonstrated that elevated IMA and adjusted IMA levels observed in patients with SSNS were associated with increased oxidative stress and could indirectly reflect the degree of oxidative damage in glomerular structures. doi: https://doi.org/10.12669/pjms.36.7.2924 How to cite this:Cakirca G, Guzelcicek A, Yilmaz K, Nas C. Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.2924 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Hypertriglyceridemia thalassemia syndrome

2018 ◽  
Vol 31 (7) ◽  
pp. 821-822
Author(s):  
Mili Jain ◽  
Wahid Ali ◽  
Brijendra Bahadur Singh ◽  
Nishant Verma ◽  
Ashutosh Kumar
Keyword(s):  
Oxidative Stress ◽  
Acute Pancreatitis ◽  
Nephrotic Syndrome ◽  
Early Recognition ◽  
Thalassemia Major ◽  
Rare Entity ◽  
Transfusion Therapy ◽  
Case Presentation ◽  
Coronary Diseases ◽  
Secondary Causes

Abstract Background Hypertriglyceridemia thalassemia syndrome is a rare entity with an unknown pathogenetic link. Case presentation We report a case of an 8-month-old female with thalassemia major and increased triglyceride (TG) levels. The clinical features were as in classical thalassemia except for a white discoloration of the plasma. After exclusion of familial triglyceridemia and secondary causes (hypothyroidism, nephrotic syndrome, drugs etc.), a diagnosis of hypertriglyceridemia thalassemia syndrome was made. Conclusions The high levels of TG in these patients are associated with oxidative stress and higher risk of acute pancreatitis and coronary diseases. An early recognition is thus essential. In our patient, the levels reduced after a transfusion therapy similar to previous reports.

Tumor necrosis factor alpha gene polymorphisms and haplotypes in Egyptian children with nephrotic syndrome

Cytokine ◽  
2018 ◽  
Vol 102 ◽  
pp. 76-82 ◽  
Author(s):  
Doaa M. Youssef ◽  
Amal S. El-Shal ◽  
Samia Hussein ◽  
Khaled Salah ◽  
Abd El Rahman E. Ahmed
Keyword(s):  
Nephrotic Syndrome ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Gene Polymorphisms ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Egyptian Children ◽  
Factor Alpha ◽  
Alpha Gene ◽  
Necrosis Factor

scholarly journals CORRELATION OF SERUM ALBUMIN AND CREATININE WITH OXIDATIVE STRESS MARKERS IN PATIENTS HAVING NEPHROTIC SYNDROME

2021 ◽  
pp. 20-24
Author(s):  
GLORY S. PARMAR ◽  
KINNARI N. MISTRY ◽  
SISHIR GANG
Keyword(s):  
Oxidative Stress ◽  
Nephrotic Syndrome ◽  
Correlation Analysis ◽  
Serum Albumin ◽  
Oxidative Stress Markers ◽  
Indian Children ◽  
Sod Activity ◽  
Stress Markers ◽  
Treatment And Prevention ◽  
The Relationship

Objective: Children with nephrotic syndrome (NS) have a stressful condition, and oxidative damage may impair their treatment response. This study aims to gain a better understanding of the relationship between oxidative stress and NS to lay the basis for further research into improved diagnostic options, treatment, and prevention of the disease. Methods: We took a blood sample from 100 Indian patients aged 2-14 y. Each patient was tested for oxidative stress. The buege method was used to assess MDA levels in patients. The pyrogallol method was used to measure SOD activity in blood serum, and the jollow method was used to measure glutathione levels. Results: The levels of oxidative stress markers (MDA, SOD, and GSH) were compared between NS patients and the control. SOD and GSH concentrations were significantly decreased in the NS group when compared to the control. In contrast, MDA level was significantly higher in the NS group than in the control. In the correlation analysis, we found that the serum SOD activity was significantly positively correlated with serum albumin and creatinine level in patients with NS. Thus, oxidative stress in children with NS is indicated by reduced antioxidant potential because of low albumin. Therefore, it is thought that oxidative stress is implicated in the development of NS in Indian children. Conclusion: We concluded that oxidative stress was intensified in children with NS due to decreased antioxidant levels caused by hypoalbuminemia.

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