scholarly journals Urinary N-Acetyl-Beta-D Glucosaminidase, a Marker of Tubular Dysfunction, in Patients with Systemic Lupus Erythematosus

2011 ◽  
Vol 2 (1) ◽  
pp. 1-11
Author(s):  
M.A. Mohsen ◽  
S.A. Abdel Karim ◽  
W.A. Sultan ◽  
T.M. Abbas
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Tubular Dysfunction ◽  
Systemic Lupus

scholarly journals Distal renal tubular acidosis in systemic lupus erythematosus

2021 ◽  
Vol 8 (11) ◽  
pp. 1755
Author(s):  
Avtar S. Dhanju ◽  
Pranjali Batra ◽  
Namit Gupta ◽  
Praneet Manekar ◽  
Suraj Bhola ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Renal Tubular Acidosis ◽  
Lupus Erythematosus ◽  
Renal Involvement ◽  
Distal Renal Tubular Acidosis ◽  
Tubular Dysfunction ◽  
Systemic Lupus ◽  
Multisystem Disorder ◽  
Renal Tubular ◽  
Autoimmune Etiology

Systemic lupus erythematosus (SLE) is a multisystem disorder of autoimmune etiology. Renal involvement is frequently seen in SLE. Tubular dysfunction is also seen in SLE. Authors report a case of distal renal tubular acidosis in patient with SLE. 

Tubular Dysfunction in Systemic Lupus erythematosus

Nephron ◽  
1984 ◽  
Vol 36 (2) ◽  
pp. 84-88 ◽  
Author(s):  
C.K. Yeung ◽  
K.L. Wong ◽  
R.P. Ng ◽  
W.L. Ng
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Tubular Dysfunction ◽  
Systemic Lupus

Renal tubular dysfunction in children with systemic lupus erythematosus

2004 ◽  
Vol 20 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Stephen D. Marks ◽  
Vanita Shah ◽  
Clarissa Pilkington ◽  
Patricia Woo ◽  
Michael J. Dillon
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Systemic Lupus ◽  
Renal Tubular

The kidney in rheumatological disorders

2020 ◽  
pp. 5001-5012
Author(s):  
Liz Lightstone ◽  
Hannah Beckwith
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Immunosuppressive Agents ◽  
Renal Involvement ◽  
Scleroderma Renal Crisis ◽  
Tubular Dysfunction ◽  
Systemic Lupus ◽  
Active Lupus Nephritis

Many rheumatological conditions have systemic effects. Antibody production, complement activation, and protein deposition can all result in damage to the kidney, sometimes with devastating sequelae. Systemic lupus erythematosus—lupus nephritis is clinically evident in up to 75% of patients with systemic lupus erythematosus (SLE), and endstage renal disease is seen in 5 to 10% of patients at 10 years. Proteinuria is the most common clinical presentation, closely followed by nonvisible haematuria and tubular abnormalities. Patients with active lupus nephritis often have features of active SLE. The gold standard for lupus nephritis diagnosis is a renal biopsy, with treatment related to histopathological features observed. Adjunctive immunosuppressive agents such as rituximab and tacrolimus are emerging as increasingly important lupus nephritis therapies. Systemic sclerosis is a multiorgan connective tissue disease. Most renal manifestations are clinically silent. By contrast, the scleroderma renal crisis is characterized by accelerated-phase hypertension and impaired renal function. It carries a high mortality risk. Rheumatoid arthritis can affect the kidneys in many ways, most commonly by causing amyloid A amyloidosis. This presents with proteinuria, often severe enough to cause nephrotic syndrome, with 50% progressing to endstage renal failure after 5 years (90% at 10 years). Renal vasculitis, mesangiocapillary glomerulonephritis, and mesangial IgA proliferative glomerulonephritis are also described. Gold and penicillamine (now rarely used) can cause proteinuria, sometimes with nephrotic syndrome. Renal involvement in Sjögren’s syndrome is generally mild, but up to a quarter of patients develop acute or chronic kidney disease, typically with evidence of tubular dysfunction. Glomerular abnormalities are rare and the most common histological abnormality is tubulointerstitial nephritis. Drug nephrotoxicity—conventional antirheumatics and over-the-counter nonsteroidal anti-inflammatory drugs are used exceptionally widely in the community and are nephrotoxic. Their almost ubiquitous use, especially during intercurrent illnesses, means they are frequent contributors to acute and chronic kidney damage.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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