Effect of Crude Mesocarp Extract of Hyphaene thebaica (doumpalm) on White Blood Cells and Differential Leucocytic Count in Wistar Albino Rats

2012 ◽  
Vol 12 (7) ◽  
pp. 207-213 ◽  
Author(s):  
Mohammed Shaibu Auwal ◽  
Abdullahi Shuaibu ◽  
Fatima Adamu Lawan ◽  
Kyari Abba Sanda ◽  
Abdulhamid Baba Njobdi ◽  
...  
Keyword(s):  
Blood Cells ◽  
White Blood Cells ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Assessment of Sub Chronic Toxicity of Sonchus cornutus in Rats

2019 ◽  
pp. 1-8
Author(s):  
Hayat Mahgoub Farah ◽  
Abdel Rahim Mohamed El Hussein ◽  
Hassan Elsubki Khalid ◽  
Halima Mohamed Osman
Keyword(s):  
Aqueous Extract ◽  
Blood Cells ◽  
Biochemical Analysis ◽  
White Blood Cells ◽  
Clinical Signs ◽  
Albino Rats ◽  
Liver And Kidney ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
Group 1

Aim: To assess the toxicity of the aqueous extract of Sonchus cornutus in Wistar albino rats. Methodology: The aqueous extract of Sonchus cornutus aerial part was administered orally to rats in group 2, 3 and 4 at a dose of 50, 500 and 2000 mg/ kg, respectively for four weeks whereas, group 1 was kept as a control. The animals were observed daily for clinical signs and mortality. Weekly, the weights of the animals were recorded, and blood samples were collected for haematological and biochemical analysis. Specimens of Liver and kidney were kept in 10% formalin for histopathology. Results: The results revealed that all the animals in the four groups survived. The extract had no adverse effects on haematology, biochemistry and histology of rats at doses of 50 and 500 mg/ kg. But dose 2000 mg/kg proved to have significant alteration in White blood cells (WBCs), Red blood cells (RBCs), Haemoglobin (Hb) and Packed cell volume (PCV). In addition, total protein, albumin, urea, creatinine, Alanin Transaminase (ALT), Asparate Transaminase (AST) were significantly (P<0.05) changed. These findings correlated with the histopathological changes on liver and kidney. Conclusion: The highest dose of S. cornutus aqueous extract (2000 mg/kg) was not fatal, but may have some toxic effects on liver and kidney.

scholarly journals Effects of Dombeya Buettneri Extracts on Heamapoietic Indices of Wistar Albino Rats

2015 ◽  
Vol 6 ◽  
pp. 41-49
Author(s):  
G O Obochi ◽  
D O Ochalefu ◽  
E O.O Amali ◽  
N Ufaruna ◽  
B Myke Mbata ◽  
...  
Keyword(s):  
Immune Response ◽  
Antioxidant Activity ◽  
Red Blood Cells ◽  
Phytic Acid ◽  
Blood Cells ◽  
White Blood Cells ◽  
Albino Rats ◽  
Low Phytic Acid ◽  
Wistar Albino Rats

The effects of Dombeya buettneri extracts on electrolyte and heamapoietic indices of wistar albino rats were studied. The results showed that there was a significant increase in red blood cells, white blood cells and hemoglobin, resulting in hemopoiesis and synthesis of hememoiety for hemogloglobin. Thephytochemical composition showed low phytic acid (trace) which suggests antioxidant activity, enhancing immunocompetence. The LD50 obtained was 2.58mg/kg, suggesting that dosage of Dombeya buettneri below this LD50 is safe. This work suggests that Dombeya buettneri may be useful inthe treatment of anemia and may boost immune response, and that administration (dosage) below 2.58mg/kg is safe

scholarly journals Effect of aspartame on biochemical and oxidative stress parameters in rat blood

2015 ◽  
Vol 67 (2) ◽  
pp. 535-545 ◽  
Author(s):  
Marko Prokic ◽  
Milica Paunovic ◽  
Milos Matic ◽  
Natasa Djordjevic ◽  
Branka Ognjanovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Biochemical Parameters ◽  
White Blood Cells ◽  
Lipid Peroxides ◽  
Hdl Cholesterol ◽  
Albino Rats ◽  
Total Body Mass ◽  
Antioxidative Status

Aspartame (ASP) is one of the most widely used nonnutritive sweeteners. This study investigates the chronic effects of ASP on hematological and biochemical parameters, and its effects on the oxidative/antioxidative status in the red blood cells of Wistar albino rats. Rats were provided with ASP (40 mg/kg/daily for six weeks) in drinking water. Increased food and fluid intake was observed in the ASP-treated rats. Total body mass was significantly decreased in the ASP-treated rats. Treatment with ASP caused an increase in the concentrations of glucose, cholesterol, LDL-cholesterol, and in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH), as well as a decrease in the levels of HDL-cholesterol in the serum. A significant decline in the number of white blood cells (WBC) was observed after ASP uptake. Based on the results we conclude that ASP induces oxidative stress, observed as an alteration of the glutathione redox status, which leads to increased concentrations of nitric oxide (NO) and lipid peroxides (LPO) in the red blood cells. Changes in biochemical parameters, lipid metabolism, as well as changes in the levels of oxidative stress markers and the appearance of signs of liver damage indicate that chronic use of ASP can lead to the development of hyperglycemia, hypercholesterolemia and associated diseases.

ALLIUM SATIVUM ESSENTIAL OIL (ASEO);

2017 ◽  
Vol 24 (04) ◽  
pp. 612-616
Author(s):  
Faisal Irshad ◽  
Hina Mawani ◽  
Sana Naz
Keyword(s):  
Essential Oil ◽  
Blood Cell ◽  
Blood Cells ◽  
Allium Sativum ◽  
White Blood Cells ◽  
Albino Rats ◽  
Serum Triglycerides ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Animal House

Objectives: To determine the effects of Allium sativum essential oil (ASEO)phytotherapy on serum triglycerides, total cholesterol, HDLc, LDLc and blood cell counts inalbino rat model. Study design: Experimental study. Setting and Duration: Animal House,Sindh Agriculture University and Isra University Hyderabad from May 2014 to January 2015.Materials and Methods: 60 albino rats were divided into four groups. Controls were givenPlacebo. Experimental rat groups were given ASEO 100 mg/kg, 200 mg/kg and 300 mg/kgorally for 30 days. Cardiac puncture was performed for blood sampling. Research variableswere analyzed on Statistix 10.0 (USA). Results: Blood lipids showed significant reduction invarious blood lipid fractions. Serum LDLc exhibited with a concomitant rise in serum HDLc (p=0.0001) in high ASEO treated rats. Red blood cells, white blood cells and platelet showedsignificant improvement ASEO fed rats (p=0.001). Conclusion: Allium sativum essential oil(ASEO) phytotherapy showed a rise in HDLc and a reduction in LDLc, triglycerides and totalcholesterol with improvement in red blood cell counts.

scholarly journals Moderate Range Static Magnetic Field Promoted Variation of Blood Parameters: An In vitro Study

2020 ◽  
Vol 8 (1) ◽  
pp. 55-64
Author(s):  
Bestoon T. Mustafa ◽  
Sardar P. Yaba ◽  
Asaad H. Ismail
Keyword(s):  
Magnetic Field ◽  
Blood Cell ◽  
Static Magnetic Field ◽  
Blood Cells ◽  
White Blood Cells ◽  
Albino Rats ◽  
Field Exposure ◽  
Blood Samples ◽  
Cell Counts

This study was undertaken to investigate the influence of a homogenous and uniform static magnetic field (SMF) on the main blood cell counts in vitro experiment. Fresh blood samples were collected from albino rats and exposed to SMF (2.4, 6, 25, 50, 75, and 100 mT) versus 15–60 min. Results showed a significant change of blood counts under the low field effects. A 2.4 mT was a trend of white blood cells (WBCs) count increase non-linearly. However, a 6 mT exposure reduced WBCs with about 39%. Other variations fluctuated within 30%. The 25 mT decreased red blood cells (RBCs), hemoglobin, and hematocrit levels with 13% similarly. The lower exposure field, (2.4 and 6) mT, and effects on RBCs were 6% fluctuation. The 6 mT reduced platelet counts with half in comparison to control blood samples. About 20% increase obtained due to 50 mT exposure during all period. None of 75 and 100 mT exposures dominated blood counts alterations. The quiet magnetic field exposure for a certain time can be interesting to control blood cell count-related diseases.

scholarly journals In Vivo Screening and Antidiabetic Potential of Polyphenol Extracts from Guava Pulp, Seeds and Leaves

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1714
Author(s):  
Hassan Shabbir ◽  
Tusneem Kausar ◽  
Sobia Noreen ◽  
Hafeez ur Rehman ◽  
Ashiq Hussain ◽  
...  
Keyword(s):  
Feed Intake ◽  
Blood Cells ◽  
White Blood Cells ◽  
Radical Scavenging ◽  
Density Lipoprotein ◽  
Total Phenolic ◽  
Control Group ◽  
Albino Rats ◽  
Control Groups

The present study investigates the antidiabetic potential of polyphenol extracts purified from guava pulp, seeds and leaves using an in vivo experiment on albino rats. The polyphenols from guava pulp, seeds and leaves were extracted using methanol solvent and the sonication method while being evaluated by total phenolic contents and radical scavenging activity assay. The proximate composition of powders revealed that ash, protein and total sugars were significantly (p < 0.05) higher in leaves and seeds, while vitamin C was highest in pulp. Total phenolic and antioxidant activities were highest in pulp followed by leaves and seeds. The findings of feed intake and body gain revealed that the supplementation of polyphenols, especially from pulp, significantly (p < 0.05) increased the feed intake, which resulted in increased body weight. Moreover, total cholesterol (TC) and low-density lipoprotein (LDL) levels were significantly (p < 0.05) decreased, while the level of high-density lipoprotein (HDL) was increased in groups fed with polyphenols from guava pulp compared to both (+ive and –ive) control groups. Furthermore, blood glucose and triglycerides were significantly (p < 0.05) decreased in supplemented groups compared to the control group of diabetes mice, which resulted in the inhibition of α-amylase and glucose transport. Besides this, packed cell volume (PCV), mean corpuscular volume (MCV), hemoglobin, red blood cells (RBCs), white blood cells (WBCs) and platelet levels were increased significantly (p < 0.05) in pulp’s extract followed by leaves and seeds compared to both control groups. Overall, the antidiabetic potential of different extracts was in the following order: pulp > leaves > seeds. The findings suggest the feasibility of adding 200–250 mg/kg.bw of polyphenol extracts of pulp as an alternative to diabetic drugs.

scholarly journals Bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on haematological profile in paracetamol-induced Wistar rats

2019 ◽  
Vol 6 (14) ◽  
pp. 521-533
Author(s):  
C. U. Ogunka-Nnoka ◽  
B. W. Abbey
Keyword(s):  
Blood Cells ◽  
Leaf Extract ◽  
White Blood Cells ◽  
Appreciable Amount ◽  
Albino Rats ◽  
Bioactive Components ◽  
Sample Extract ◽  
Significant Difference ◽  
Haematological Profile ◽  
Aqueous Leaf Extract

The study evaluates the bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on the haematological profile of paracetamol-induced Wistar albino rats. Standard methods were used in the proximate, phytochemical and haematological profile analysis. The results of the proximate composition revealed high values for crude fiber (49.13%), carbohydrates (16.33%) and protein (10.94%). Phytochemical studies showed the presence of alkaloids, flavonoids, saponins, phenols and tannins within the concentration range of 0.0003-94.68 µg/mL. Twenty-four hours after the last oral administration, the rats were sacrificed. Blood was obtained by cardiac puncture. Results of the haematological profile at different dose levels (200 mg/kg, 300 mg/kg and 500 mg/kg body weight) did not show any significant difference (p > 0.05) when compared with the control. A slight increase was observed in the erythrocytes (red blood cells, haemoglobin, packed cell volume and platelets). Meanwhile, a significant increase (p <= 0.05) was observed in the WBC and platelets of the groups induced with paracetamol only. However, administration of ascorbic and the sample extract reduced the white blood cells and platelet levels. The study revealed that M. barteri leaves contain an appreciable amount of nutrients, bioactive constituents and may serve as a blood booster.

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