Total Antioxidant Status is Related to the CD4+ Cell Count and the Clinical State of HIV/AIDS Patients in the Northeast, Nigeria

2007 ◽  
Vol 8 (1) ◽  
pp. 49-53 ◽  
Author(s):  
A.C.U. Ezimah ◽  
E.A. Nwankwo ◽  
G.R.A. Okogun ◽  
J.C. Ihongbe ◽  
P.A. Onyeyili ◽  
...  
Keyword(s):  
Cell Count ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Clinical State ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Total Antioxidant ◽  
Cd4 Cell ◽  
Northeast Nigeria ◽  
Hiv Aids

scholarly journals Enhanced Oxidative Stress Markers and Antioxidant Imbalance in HIV Infection and AIDS Patients

2009 ◽  
Vol 1 (2) ◽  
pp. 370-380 ◽  
Author(s):  
P. Pasupathi ◽  
T. Ramchandran ◽  
P. J. Sindhu ◽  
G. Saranavan ◽  
G. Bakthavathsalam
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Hiv Infection ◽  
Cell Count ◽  
Antioxidant Status ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Control Subjects ◽  
Cd4 Cell ◽  
Hiv Aids

The aim of this study was to investigate lipid peroxidation as evidenced by thiobarbutric acid reactive substances (TBARS), ceruloplasmin (Ce), CD4+ cells counts and antioxidant, and micronutrients status in HIV infection and AIDS patients. The level of plasma and erythrocyte TBARS, plasma ceruloplasmin was markedly increased in the AIDS patients when compared to HIV infection and healthy control subjects. We observed a significant reduction in CD4+ cell count in HIV/AIDS patients when compared to control subjects. The activities of erythrocyte antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and reduced glutathione (GSH), were significantly decreased in AIDS patients when compared with HIV infection and healthy subjects. Significantly low levels of plasma GSH, vitamin A (β-carotene), vitamin C, vitamin E, serum uric acid, albumin, selenium and zinc were also observed in AIDS patients when compared with HIV positive patients and control subjects. The study highlights the occurrence of lipid peroxidation and possible breakdown of antioxidant status in HIV/AIDS patients, which may subsequently increase the possibility of poor immunity. The antioxidant status was progressively depleted in HIV infected persons as the disease progressed from a symptomatic state to AIDS.Keywords: Oxidative stress; HIV; AIDS; CD4+ cell count; Antioxidant status.© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.v1i2.2295

Effects of CD4 cell count and antiretroviral therapy on mucocutaneous manifestations among HIV/AIDS patients in Yunnan, China

2019 ◽  
Vol 59 (3) ◽  
pp. 308-313 ◽  
Author(s):  
Yu‐Ye Li ◽  
Shi‐Han Yang ◽  
Rui‐Rui Wang ◽  
Jun‐Ting Tang ◽  
Hong‐Mei Wang ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Cell Count ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cd4 Cell ◽  
Hiv Aids

scholarly journals The Effect of Vitamin D Supplementation on the Increase in CD4 count of HIV/AIDS Patients Receiving Antiretroviral Therapy

2020 ◽  
Vol 5 (1) ◽  
pp. 144-147
Author(s):  
Mega Permata ◽  
Harun Hudari ◽  
Mediarty ◽  
Taufik Indrajaya
Keyword(s):  
Vitamin D ◽  
Cell Count ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Antiretroviral Drugs ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Cell Counts ◽  
Cd4 Cell ◽  
Hiv Aids

Introduction. Vitamin D plays a role in health overall, but hypovitaminosis D stilloccurs throughout the world. HIV/AIDS patients are prone to suffer fromhypovitaminosis D because of the infection itself and the side effects of antiretroviraltherapy. Various effort have been tried to improve the immune status of HIV/AIDSpatients, one of them is by adding vitamin D. Vitamin D acts as an antiinflammatoryso that it can prevent apoptosis of CD4 T cells and increase CD4 cell count.Methods. This is a randomized control trial add on a study that aims to determinethe effect of vitamin D to increase in CD4 counts of HIV / AIDS patients who havereceived antiretroviral drugs. Subjects were HIV / AIDS patients who had receivedantiretroviral drugs. A total of 20 subjects were divided randomly into two groups;one group received vitamin D (calcitriol 0.5 mcg per day) for eight weeks, and theother group that received a placebo. Each group was measured of CD4 cell countbefore and after treatment. Results. There was a significant increase in the CD4 cellcount of the vitamin D group (p = 0.046), but not in the CD4 cell count of bothgroups (p = 0.985). The comparison of mean CD4 cell counts between groups beforetreatment was not significantly different (p = 0.057), but after treatment, it becamesignificantly different (p = 0.040). Conclusion. Vitamin D has been successful inincreasing CD4 cell count in the vitamin D group, and it is recommended to giveHIV / AIDS patients to increase CD4 cell count.

scholarly journals Hubungan antara Fatigue, Jumlah CD4, dan Kadar Hemoglobin pada Pasien yang Terinfeksi Human Immunodeficiency Virus (HIV)

2018 ◽  
Vol 5 (3) ◽  
Author(s):  
Kusman Ibrahim ◽  
Yusshy Kurnia H ◽  
Laili Rahayuwati ◽  
Baiq Emi Nurmalisa ◽  
Siti Ulfah Rifa’atul Fitri
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cell Count ◽  
Pearson Correlation ◽  
Hemoglobin Level ◽  
Aids Patients ◽  
Cd4 Cell Count ◽  
Fatigue Score ◽  
Immunodeficiency Virus ◽  
Cd4 Cell ◽  
Hiv Aids

Keberadaan Human Immunodeficiency Virus (HIV) di dalam tubuh secara terus menerus menyebabkan gangguan pada hampir semua sistem tubuh yang berdampak pada munculnya gejala kelelahan (fatigue). Fatigue banyak dilaporkan pada penderita HIV/AIDS dengan prevalensi berkisar antara 20% sampai 60%. Penelitian ini bertujuan menguji hubungan antara fatigue dengan jumlah CD4 dan kadar Hb pada pasien HIV/AIDS. Sebanyak 77 responden direkrut secara purposif di sebuah Klinik Rawat Jalan Rumah Sakit di Kota Bandung. Fatigue diukur menggunakan kuesioner HIV Related Fatigue Score (HRFS). Data yang terkumpul dianalisis menggunakan uji pearson correlation. Hasil penelitian menunjukkan terdapat hubungan yang bermakna antara fatigue dengan jumlah CD4 dalam darah (r = -.289, p< 0.05) dan kadar Hb (r = -.349, p< 0.05). Selain itu, kadar Hb memiliki hubungan yang bermakna dengan jumlah CD4 pada pasien HIV/AIDS (r = .360, p < .01). Hasil penelitian ini mengindikasikan perlunya monitoring kadar CD4 dan Hb secara berkala dan melakukan intervensi untuk mengatasi penurunan Hb dan CD4 sesegera mungkin sehingga dapat mencegah agar fatigue tidak berkelanjutan.Kata kunci: CD4, fatigue, hemoglobin, HIV/AIDS. The Correlation of Between Fatigue, CD4 Cell Count, and Hemoglobin Level among HIV/AIDS PatientsAbstractThe existence of Human Immunodeficiency Virus (HIV) in the body continuously causes disruption in almost all body systems that impact on the emergence of symptoms of fatigue. Fatigue was widely reported in HIV/AIDS patients with prevalence ranging from 20% to 60%. This study examined the relationship between fatigue and CD4 cell count and hemoglobin levels in HIV/AIDS patients. A total of 77 respondents were recruited purposively in Outpatient Clinic, General Hospital Bandung City. Fatigue was measured using the HIV Related Fatigue Score (HRFS) questionnaire. The collected data were analyzed using pearson correlation product moment. The results showed there were significant relationship between fatigue and CD4 count in blood (r = -.289, p< 0.05) and hemoglobin level (r = -.349, p< 0.05). In addition, CD4 had significantly correlation with Hb (r = .360, p < .01). The results of this study indicated that nurses or health care providers need to periodically monitor the CD4 and Hb levels and provide early intervention to manage the hemoglobin and CD4 cell count at optimum levels to prevent prolonging fatiguel.Keywords: CD4, fatigue, hemoglobin, HIV/AIDS.

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