C-terminal Propeptide of Type-I Procollagen as a Possible Biochemical Marker for Preclinical Detection of Cardiac Disease in Chronic Renal Failure

2007 ◽  
Vol 7 (5) ◽  
pp. 804-809
Author(s):  
Azza Mohamed Omar Ab Rahmant ◽  
Sally Ahmed Farid El . ◽  
Ihab Zaki El-Hakim . ◽  
Maha Amin Rasheed .
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiac Disease ◽  
Biochemical Marker ◽  
Type I ◽  
Type I Procollagen

scholarly journals Evolution of Circulating C-Terminal Propeptide of Type I Procollagen in Patients with Chronic Renal Failure Pre and Post Renal Transplantation

1996 ◽  
Vol 34 (11) ◽  
Author(s):  
Maria R. Bonnin ◽  
María T. Gonzalez ◽  
José M. Griñó ◽  
José M. Cruzado ◽  
José M. Martínez ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Type I ◽  
Type I Procollagen

A radioimmunoassay for bone Gla protein (BGP) in human plasma

1987 ◽  
Vol 114 (3) ◽  
pp. 410-416 ◽  
Author(s):  
Julia S. Johansen ◽  
J. E. Mølholm Hansen ◽  
Claus Christiansen
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Human Plasma ◽  
Biochemical Marker ◽  
Normal Subjects ◽  
Bone Gla Protein ◽  
Low Concentrations ◽  
Metabolic Bone ◽  
The Mean ◽  
Bone Physiology

Abstract. To study the value of bone Gla protein (BGP) as a biochemical marker of normal bone physiology and metabolic bone disorders, we have developed a radioimmunoassay (RIA) for the detection of BGP in human plasma. Antibodies were generated in rabbits immunized with purified calf BGP conjugated to thyroglobulin. Human plasma BGP reacted identically with the calf BGP standard, thus demonstrating the suitability of the assay to measure plasma BGP levels in man. The RIA is sensitive, accurate, and technically simple. Plasma BGP levels were determined in normal subjects (N = 35) and in patients with hypothyroidism (N = 10), hyperthyroidism (N = 22) and chronic renal failure (N = 35). The mean (± 1 sem) concentration of plasma BGP in normal subjects was 1.27 ± 0.07 nmol/l. Plasma BGP was significantly increased in patients with hyperthyroidism, 4.04 ± 0.78 nmol/l (P < 0.001) and chronic renal failure, 10.17 ± 2.47 nmol/l (P < 0.001). Low concentrations were found in patients with hypothyroidism, 0.74 ± 0.11 nmol/l (P <0.01). Our studies indicate that plasma BGP provides a useful technique in the diagnosis of patients with bone disease.

scholarly journals Niaoduqing Granules Inhibits TGF-β1-induced Epithelial-Mesenchymal Transition in Human Renal Tubular Epithelial HK-2 Cells

2020 ◽  
Author(s):  
Chu-Ying Huo ◽  
Hua-Yi Yang ◽  
Wei-Min Ning ◽  
Lin-Zhong Yu ◽  
Chun-Lin Fan ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Morphological Changes ◽  
Migration And Invasion ◽  
Type I ◽  
Mesenchymal Transition ◽  
Public Health Burden ◽  
Fluorescence Confocal Microscopy ◽  
Renal Tubular ◽  
Tgf Β1

Abstract Background: Chronic renal failure (CRF) is a worldwide public health burden. Niaoduqing granules (NDQ) is widely used for CRF treatment in China. However, the underlying mechanism of NDQ is not fully studied. This study is aimed to investigate whether NDQ ameliorate CRF by inhibiting TGF-β1-induced EMT in human renal tubular epithelial HK-2 cells.Methods: MTT assay and colony formation assay were used to investigate the cytotoxicity of NDQ in HK-2 cells. Morphological changes of HK-2 cells after TGF-β1 or/and NDQ treatment were observed under a microscope. Wound-healing, migration and invasion assays were performed to determine the cell movement, migratory and invasive abilities, respectively. Western blot analysis was carried out to examine the protein levels of TGF-β type I receptor (TβRI) and EMT-associated factors. Fluorescence confocal microscopy was applied to observe the organization of F-actin.Results: NDQ suppressed TβRI expression dose-dependently. NDQ inhibited TGF-β1-stimulated EMT in HK-2 cells, supported by the evidences that NDQ prevented morphology change, attenuated cell migration and invasion, downregulated EMT factors and reorganized F-actin distribution in TGF-β1-stimulated HK-2 cells.Conclusions: NDQ attenuates chronic renal failure which may be associated with inhibition of TβRI expression and EMT process.

The clinical significance of serum osteocalcin and N-terminal propeptide of type I collagen in predialysis patients with chronic renal failure

2004 ◽  
Vol 16 (2) ◽  
pp. 172-179 ◽  
Author(s):  
Takao Tsuchida ◽  
Eiji Ishimura ◽  
Takami Miki ◽  
Naoki Matsumoto ◽  
Hiroshi Naka ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Clinical Significance ◽  
Type I Collagen ◽  
Type I ◽  
Serum Osteocalcin

scholarly journals Salivary Cystatin C as a Biochemical Marker for Chronic Renal Failure

2018 ◽  
Vol 13 (5) ◽  
Author(s):  
Abdulsalam Tawfeeq Salih Alsamarai ◽  
Amani Ayad Husain ◽  
Taiseer Abdul-Kader Saleh ◽  
Noor Mohamad Thabit
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cystatin C ◽  
Biochemical Marker

scholarly journals Effects of Different Hemodialysis Treatments on Abnormal Mineral and Bone Metabolism in Patients with Chronic Renal Failure

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Qiang Li
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Bone Metabolism ◽  
Type I ◽  
High Flux ◽  
Blood Calcium ◽  
Amino Terminal ◽  
Group A ◽  
The Difference ◽  
Group B

Objective: To investigate the effects of different hemodialysis treatments on abnormal mineral and bone metabolism in patients with chronic renal failure. Methods: A random number table was used to divide 80 patients with chronic renal failure admitted to our hospital from January 2018 to January 2019 into 2 groups, with 40 cases in each group. Group A was treated with low-flux hemodialysis, and group B was treated with high-flux hemodialysis. The related indicators of mineral and bone metabolism of the two groups were compared. Results: Before treatment, the blood calcium, blood phosphorus, intact parathyroid hormone (iPTH), type I procollagen amino terminal peptide (PINP), fibroblast growth factor 23 (FGF23), serum creatinine (Scr) indicators of the two groups were compared. The difference was not statistically significant(P>0.05); After treatment, the blood calcium levels of the two groups were higher than before treatment, the blood phosphorus, iPTH, PINP, FGF23, and Scr levels were lower than before treatment, and the blood calcium level of group B was higher than that of group A, while blood phosphorus, iPTH, PINP, FGF23, and Scr levels were lower than group A, the difference was statistically significant (P<0.05). Conclusion: Compared with low-flux hemodialysis, patients with chronic renal failure treated with high-flux hemodialysis have better results, which can correct abnormal bone metabolism and improve Scr levels.

Changes in Serum Type I and III Procollagen Levels in Children with Chronic Renal Failure

Nephron ◽  
1996 ◽  
Vol 72 (2) ◽  
pp. 189-191 ◽  
Author(s):  
Peyami Cinaz ◽  
Necla Buyan ◽  
Nahide Gökçora ◽  
ǧehri Elbeg ◽  
Enver Hasanoğlu
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Type I ◽  
Serum Type

scholarly journals A Human T-Cell Lymphotropic Virus Type-I Carrier with Chronic Renal Failure, Aplastic Anemia, Myelopathy, Uveitis, Sjoegren's Syndrome and Panniculitis.

1996 ◽  
Vol 35 (9) ◽  
pp. 742-745 ◽  
Author(s):  
Motomi OSATO ◽  
Kazunari YAMAGUCHI ◽  
Sadahiro TAMIYA ◽  
Hiroshi YAMASAKI ◽  
Toshiya OKUBO ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
T Cell ◽  
Aplastic Anemia ◽  
Virus Type ◽  
Type I ◽  
Human T Cell ◽  
Sjoegren’S Syndrome
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