Morphological Features of Normal Human Skeletal Muscle in Different Age Groups: A Histological and Ultrastructural Study

2007 ◽  
Vol 7 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Raesa A. Mohamed ◽  
Hoda M. El Aasar ◽  
Lobna A. Mohamed ◽  
Amal M. Abbas
Keyword(s):  
Skeletal Muscle ◽  
Ultrastructural Study ◽  
Human Skeletal Muscle ◽  
Age Groups ◽  
Morphological Features ◽  
Normal Human

scholarly journals THE DISTRIBUTION OF LACTATE DEHYDROGENASE ISOZYMES IN HUMAN SKELETAL MUSCLE FIBERS

1964 ◽  
Vol 12 (8) ◽  
pp. 608-614 ◽  
Author(s):  
M. VAN WIJHE ◽  
M. C. BLANCHAER ◽  
S. ST. GEORGE-STUBBS
Keyword(s):  
Skeletal Muscle ◽  
Lactate Dehydrogenase ◽  
Human Skeletal Muscle ◽  
Muscle Fibers ◽  
Isozyme Pattern ◽  
Electrophoretic Separation ◽  
Lactate Dehydrogenase Isozymes ◽  
Dehydrogenase Isozyme ◽  
Lactate Dehydrogenase Isozyme ◽  
Normal Human

A study of the distribution of lactate dehydrogenase isozymes in single fibers from normal human skeletal muscle is presented. The fibers were classified into red, intermediate and white types on histochemical grounds and their lactate dehydrogenase isozyme content assessed by electrophoretic separation in veronal buffered agar. The results generally agreed with previous homogenate studies on animal skeletal muscle, in that the white fibers contained almost exclusively isozymes IV and V, whereas red fibers were rich in isozymes I, II and III, but IV and V also appeared indigenous to these fibers. The intermediate fibers had an isozyme pattern combining the features of red and white fibers. The metabolic implications of these findings are discussed.

Assessment of transcapillary glucose exchange in human skeletal muscle and adipose tissue

2003 ◽  
Vol 285 (2) ◽  
pp. E241-E251 ◽  
Author(s):  
Werner Regittnig ◽  
Martin Ellmerer ◽  
Günter Fauler ◽  
Gerald Sendlhofer ◽  
Zlatko Trajanoski ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Human Subjects ◽  
Quadriceps Muscle ◽  
Model Parameters ◽  
Interstitial Glucose ◽  
Normal Human ◽  
Dynamic Relationships ◽  
Subcutaneous Adipose

We studied the kinetics of glucose exchange between plasma and interstitial fluid (ISF) in human skeletal muscle and adipose tissue under fasting conditions. Five normal human subjects received an intravenous [6,6-2H2]glucose infusion in a prime-continuous fashion. During the tracer infusion, the open-flow microperfusion technique was employed to frequently sample ISF from quadriceps muscle and subcutaneous adipose tissue. The tracer glucose kinetics observed in muscle and adipose tissue ISF were found to be well described by a capillary-tissue exchange model. As a measure of transcapillary glucose exchange efficiency, the 95% equilibrium time was calculated from the identified model parameters. This time constant was similar for skeletal muscle and adipose tissue (28.6 ± 3.2 vs. 26.8 ± 3.6 min; P = 0.60). Furthermore, we found that the (total) interstitial glucose concentration was significantly lower ( P < 0.01) in muscle (3.32 ± 0.46 mmol/l) and adipose tissue (3.51 ± 0.17 mmol/l) compared with arterialized plasma levels (5.56 ± 0.13 mmol/l). Thus the observed gradients and dynamic relationships between plasma and ISF glucose in muscle and adipose tissue provide evidence that transcapillary exchange of glucose is limited in these two tissues under fasting conditions.

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