scholarly journals Determination of Interleukin-6 (IL-6) in Cerebrospinal Fluid: Potential Role for the Evaluation of the Vital Prognosis in Bacterial Meningitis

2016 ◽  
Vol 16 (4) ◽  
pp. 136-140 ◽  
Author(s):  
Ibrahim Dan Dano ◽  
Odile Ouwe Missi Oukem-Boye ◽  
Ali Elhadji Mahamane ◽  
Hassimi Sadou
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Interleukin 6 ◽  
Potential Role ◽  
Fluid Potential

scholarly journals The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Okko Savonius ◽  
Irmeli Roine ◽  
Saeed Alassiri ◽  
Taina Tervahartiala ◽  
Otto Helve ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cerebrospinal Fluid ◽  
Matrix Metalloproteinases ◽  
Bacterial Meningitis ◽  
Confidence Interval ◽  
Potential Role ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Inflammatory Cascade ◽  
Disease Outcomes

Background. Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis. We determined levels of MPO, MMP-8, MMP-9, and tissue inhibitor of metalloproteinase- (TIMP-) 1 in the CSF of children with bacterial meningitis and investigated how these inflammatory mediators relate to each other and to the disease outcomes. Methods. Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996–2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays. Results. MPO correlated positively with MMP-8 (rho 0.496, P<0.001) and MMP-9 (rho 0.153, P=0.02) but negatively with TIMP-1 (rho -0.361, P<0.001). MMP-8 emerged as the best predictor of disease outcomes: a CSF MMP-8 concentration above the median increased the odds of death 4.9-fold (95% confidence interval 1.8–12.9). Conclusions. CSF MMP-8 presented as an attractive prognostic marker in children with bacterial meningitis.

Immunoglobulins in cerebrospinal fluid in various neurologic disorders.

1980 ◽  
Vol 26 (1) ◽  
pp. 115-116 ◽  
Author(s):  
A Bouloukos ◽  
J Lekakis ◽  
J Michael ◽  
A Kalofoutis
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Neurologic Disorders ◽  
The Absolute

Abstract We determined the concentrations of immunoglobulins A, G, and M in cerebrospinal fluid of 16 patients suffering from multiple sclerosis, 13 with non-bacterial meningitis, 10 with stroke syndrome, and 13 with epilepsy. The differences in concentrations of immunoglobulins in these groups were remarkable in the patients with multiple sclerosis, meningitis, or stroke syndrome. We propose that the determination of the absolute immunoglobulin content in cerebrospinal fluid is of greater significance than the relative immunoglobulin concentration.

scholarly journals IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis

2011 ◽  
Vol 15 (2) ◽  
pp. 156-158 ◽  
Author(s):  
Vitor Laerte Laerte Pinto Junior ◽  
Maria Cristina Rebelo ◽  
Rachel Novaes Gomes ◽  
Edson Fernandes de Assis ◽  
Hugo C Castro-Faria-Neto ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Bacterial Meningitis ◽  
Aseptic Meningitis ◽  
Potential Role

Immunoglobulins in cerebrospinal fluid in various neurologic disorders.

1980 ◽  
Vol 26 (1) ◽  
pp. 115-116
Author(s):  
A Bouloukos ◽  
J Lekakis ◽  
J Michael ◽  
A Kalofoutis
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Neurologic Disorders ◽  
The Absolute

Abstract We determined the concentrations of immunoglobulins A, G, and M in cerebrospinal fluid of 16 patients suffering from multiple sclerosis, 13 with non-bacterial meningitis, 10 with stroke syndrome, and 13 with epilepsy. The differences in concentrations of immunoglobulins in these groups were remarkable in the patients with multiple sclerosis, meningitis, or stroke syndrome. We propose that the determination of the absolute immunoglobulin content in cerebrospinal fluid is of greater significance than the relative immunoglobulin concentration.

scholarly journals IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis

2011 ◽  
Vol 15 (2) ◽  
pp. 156-158 ◽  
Author(s):  
Vitor Laerte Laerte Pinto Junior ◽  
Maria Cristina Rebelo ◽  
Rachel Novaes Gomes ◽  
Edson Fernandes de Assis ◽  
Hugo C. Castro-Faria-Neto ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Bacterial Meningitis ◽  
Aseptic Meningitis ◽  
Potential Role

Nitric oxide accelerates the degradation of tetrahydrobiopterin but not total neopterin in cerebrospinal fluid; potential implications for the assessment of tetrahydrobiopterin metabolism

2007 ◽  
Vol 44 (4) ◽  
pp. 394-396 ◽  
Author(s):  
A A J Lam ◽  
S J R Heales
Keyword(s):  
Nitric Oxide ◽  
Cerebrospinal Fluid ◽  
Oxide Formation ◽  
Accelerated Degradation ◽  
Nitric Oxide Formation ◽  
Neopterin Concentration ◽  
Fluid Potential

Assessment of total neopterin and tetrahydrobioterin (BH4) concentrations in cerebrospinal fluid (CSF) can be used to identify potential disorders of BH4 biosynthesis. In this study, we demonstrate that exposure of CSF to nitric oxide leads to an accelerated degradation of BH4 but does not affect the total neopterin concentration. These data suggest that in those conditions associated with increased nitric oxide formation, perturbation of the total neopterin to BH4 ratio could occur. Under such circumstances a putative diagnosis of a defect in BH4 biosynthesis may erroneously be proposed. Assessment of central nitric oxide generation may therefore be a useful adjunct to the determination of CSF pterin status.

Usefulness of interleukin 6 levels in the cerebrospinal fluid for the diagnosis of bacterial meningitis

2014 ◽  
Vol 29 (4) ◽  
pp. 693.e1-693.e6 ◽  
Author(s):  
Waka Takahashi ◽  
Taka-aki Nakada ◽  
Ryuzo Abe ◽  
Kumiko Tanaka ◽  
Yosuke Matsumura ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Interleukin 6

scholarly journals Measurement of Interleukin-6 in Cerebrospinal Fluid for the Diagnosis of Bacterial Meningitis

2016 ◽  
Vol 19 (4) ◽  
pp. 185-190 ◽  
Author(s):  
Ibrahim Dan Dano ◽  
Hassimi Sadou ◽  
Bassira Issaka ◽  
Odile Ouwe Missi Oukem-Boye
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Interleukin 6
Sign in / Sign up

Export Citation Format

Share Document