scholarly journals Nanoparticles Effects on Zinc Oxide/green Tea Complex on the Lipid Profile and Liver Functions of Rats after Monosodium Glutamate Treatment

2018 ◽  
Vol 18 (2) ◽  
pp. 65-70 ◽  
Author(s):  
Reham Z. Hamza ◽  
Fawziah A. Al-Salm ◽  
Nahla S. El-Shen
Keyword(s):  
Zinc Oxide ◽  
Lipid Profile ◽  
Green Tea ◽  
Monosodium Glutamate ◽  
Liver Functions

The Interaction of Zinc Oxide/Green Tea Extract Complex Nanoparticles and its Effect on Monosodium Glutamate Toxicity in Liver of Rats

2019 ◽  
Vol 20 (6) ◽  
pp. 465-475 ◽  
Author(s):  
Fawziah A. Al-Salmi ◽  
Reham Z. Hamza ◽  
Nahla S. El-Shenawy
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Green Tea ◽  
Zinc Oxide Nanoparticles ◽  
Monosodium Glutamate ◽  
Green Tea Extract ◽  
Control Group ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Tea Extract

Background: Zinc oxide nanoparticles (ZnO NPs) are increasingly utilized in both industrial and medical applications. Therefore, the study was aimed to investigate the effect of green nanoparticle complex (green tea extract/zinc oxide nanoparticles complex, GTE/ZnO NPs) on oxidative stress induced by monosodium glutamate (MSG) on the liver of rats. Methods: Wistar male rats (n=64) weighing between 200-250 g were divided randomly into eight groups: control group was given physiological saline (1 mg/kg), two groups were treated with two different doses of MSG (MSG-LD, MSG-HD; 6 and 17.5 mg/Kg, respectively), GTE was given 1 mg/mL, 5th group was treated with ZnO NPs and 6th group was treated with GTE/ZnO NPs complex while, 7th and 8th groups were treated with MSG-LD + GTE/ZnO NPs complex and MSG-HD + GTE/ZnO NPs complex, respectively. All substances were given orally for 30 consecutive days. At the end of the study, the liver was homogenized for measurement of the oxidative stress status and anti-inflammatory biomarkers as well as histological and transmission alternations. Results: Results showed that the antioxidant enzymes activity and glutathione level were significantly decreased in MSG groups than control in a dose-dependent manner. Conversely, the malondialdehyde and inflammatory cytokines levels were significantly increased in MSG groups than the control group. The liver indicated no evidence of alteration in oxidative status, anti-inflammatory and morphological parameters in GTE, ZnO NPs and GTE/ZnO NPs complex groups. Conclusion: In conclusion, MSG at both doses caused oxidative stress and inflammation on liver after 28 days of exposure that supported histological analysis and transmission view of hepatic parenchyma. GTE/ZnO NPs act as partial hepato-protective against MSG.

scholarly journals Effect of Green Tea and Zinc oxide Nanoparticles Complex on Histopathology of Spleen of Male Rats Induced by Monosodium Glutamate

2019 ◽  
pp. 04-11
Author(s):  
Fawziah A Al-Salmi ◽  
Reham Z Hamza ◽  
Nahla S El-Shenawy
Keyword(s):  
Zinc Oxide ◽  
Green Tea ◽  
Zinc Oxide Nanoparticles ◽  
Monosodium Glutamate ◽  
Male Rats ◽  
Albino Rats ◽  
Oxide Nanoparticles ◽  
White Pulp ◽  
Zno Nps ◽  
Red Pulp

Background and objective: Synthesis of zinc oxide nanoparticles (ZnO NPs) with green tea extract (GTE) to form a complex is known to be one of the most multiuse nanoparticles with its application in treatment the toxicity of monosodium glutamate (MSG) on liver, kidney, testis, and pancreas. Therefore, the present study was concerned with the pontifical effect of ZnO NPs / GTE complex on the histological structure of spleen exposed to MSG. Materials and Methods: The toxicity of MSG was evaluated in male albino rats using two dosages (low, 6.0 and high, 17.5 mg/kg). The albino rats were taken for the experiment and randomly assigned into six groups; control, ZnO NPs, MSG-LD, MSG-HD, ZnO NPs / GTE + MSG-LD, and ZnO NPs / GTE + MSG-HD. The animals were decapitated after 30 days of exposure and spleens were dissected out and processed for the histological examination by light microscope. Results: The result revealed that MSG causes shrinkage in the white pulp nodule with increasing the area of the white pulp and degeneration of red pulp as compared to the control. The changes were more prominent in the rats treated with the higher dosage of MSG. The finding suggests that MSG may effect on adhesion of splenocytes and degeneration of red pulp in the rat leading to the reduced immunogenic response. Conclusions: The data could be demonstrated the effect of MSG on spleen tissue was a dose-dependent and led to hypertrophy of white pulp of the spleen. The ZnO NPs/GTE complex could provide a protective benefit against MSG-induced splenomegaly through its potent antioxidant properties due to the presence of GTE and reduction of the ZnO. The future study will be a concern on the thymus histology as it acts as the center of lymphoid organ. Keywords: Monosodium glutamate, ZnO nanoparticles, Spleen, Histology, Rats

scholarly journals Cardioprotective Effect of Zinc Oxide Nanoparticles/Green Tea Extract Complex on Monosodium Glutamate Toxicity

2019 ◽  
pp. 1-5
Author(s):  
Nahla S. El-Shenawy ◽  
Reham Z. Hamza ◽  
Fawziah A. Al-Salmi
Keyword(s):  
Zinc Oxide ◽  
Body Weight ◽  
Green Tea ◽  
Zinc Oxide Nanoparticles ◽  
Monosodium Glutamate ◽  
Heart Tissue ◽  
Green Tea Extract ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Tea Extract

Monosodium glutamate (MSG) is used worldwide as a food additive, the survey has disclosed some of MSG's deleterious effects on various organs and tissues of rats. This research was achieved to determine the impact of MSG on the albino rats' antioxidant and histology of cardiac tissue. 48 male rats were divided into six groups of eight rats each. Group one used for monitoring and normal saline, whereas rats of group two were given the lower dosage of MSG 6 mg/Kg, rats in group three received 17.5 m/kg body weight of MSG, while rats in group four were given 10 mg/kg body weight of zinc oxide nanoparticles /green tea extract (ZnO NPs/GTE) complex, the fifth and sixth groups were treated with the lower and the higher doses of MSG with ZnO NP/GTE complex for 30 days. Each animal was sacrificed at the end of the treatment period and the heart was thoroughly separated, determining the antioxidant parameter and the histopathological changes. MSG administration to the rats has shown a substantial rise in peroxidation of cardiac heart tissue, decline in the activities of catalase, superoxide dismutase, and glutathione peroxidase beside the decrease in the glutathione level as compared to those in the control animals. The treatment the induced-rats with MSG using complex showed some degree of recovery by a reduction in LPO of the heart and enhancement of antioxidant enzymes. The findings suggested that the intrinsic antioxidant of the heart tissue can significantly be alternated with the use of MSG in a dose-dependent manner and these changes could be improved by using the green ZnO NPs complex. This complex acts as a factor to decrease the histological damage that could be happening by the induction of MSG.

Zinc oxide nanoparticles with green tea extract complex in the pancreas of rats against monosodium glutamate toxicity

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Reham Z. Hamza ◽  
Fawziah A. Al-Salmi ◽  
Nahla S. El-Shenawy
Keyword(s):  
Zinc Oxide ◽  
Green Tea ◽  
Zinc Oxide Nanoparticles ◽  
Monosodium Glutamate ◽  
Green Tea Extract ◽  
Glutamate Toxicity ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Pancreatic Cell ◽  
Tea Extract

AbstractObjectivesNanotechnology is an exciting field for investigators. Green zinc oxide nanoparticles (ZnO NPs) with Camellia sinensis extract complex are proved to be used in the treatment of the toxicity of monosodium glutamate (MSG) in the liver, kidney, and testis of rats. Therefore, the synthesized complex of green nanoparticles using green tea extract (GTE) was tested against the toxicity of MSG on the pancreas.MethodsThe glucose and insulin levels were estimated as well as some biochemical parameters for evaluating the antioxidant status of the pancreas tissue. The histopathological change of the pancreas also has been determined.ResultsIt indicates the biomedical capability of ZnO NPs/GTE to act as potent antidiabetic through decreasing blood glucose and increasing serum insulin also, inhibition of lipid peroxidation and enhancement of the antioxidant parameters.ConclusionsThe ZnO NPs/GTE enhanced the pancreatic cell and Langerhans islets as well lowered the sugar levels and stimulated insulin.

Ameliorative Role of Green Tea and Zinc Oxide Nanoparticles Complex Against Monosodium Glutamate-Induced Testicular Toxicity in Male Rats

2020 ◽  
Vol 21 (6) ◽  
pp. 488-501 ◽  
Author(s):  
Reham Z. Hamza ◽  
Fawziah A. Al-Salmi ◽  
Hebatullah Laban ◽  
Nahla S. El-Shenawy
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Zinc Oxide ◽  
Green Tea ◽  
Zinc Oxide Nanoparticles ◽  
Monosodium Glutamate ◽  
Male Rats ◽  
Histological Structure ◽  
Oxide Nanoparticles ◽  
Testosterone Levels

Background and Objective: This study was designed to estimate the long-term effects of zinc oxide nanoparticles/green tea (ZnONPs/GTE) complex against monosodium glutamate (MSG). The antioxidant/oxidative status, testosterone levels, DNA damage, and histopathological changes of testis were evaluated. Methods: The rats were divided into eight groups that were treated as follows: saline, the lower dosage of MSG (6.0 mg/kg), the higher dosage of MSG (17.5 mg/Kg), GTE, ZnONPs, ZnONPs/GTE and the last two groups were treated with the lower dosage of MSG or the higher dosage of MSG with ZnONPs/GTE complex. The data showed minimal toxicity in testicular tissue after the administration of ZnONPs. Results: The MSG treatment in the adult male rats reduced testosterone levels and disrupted testicular histology, which revealed dose-dependence of MSG. Also, ZnONPs induced testicular dysfunction through the interference of antioxidant/oxidant balance and suppression of testosterone levels as well as induction of cellular damage of testis. The combination of ZnONPs with GTE complex significantly protects against MSG or ZnONPs toxicity by decreasing the DNA damage, oxidative stress, and enhancement of antioxidant as well as histological structure of testis. Conclusion: We could recommend using ZnONPs/GTE complex to reduce the toxicity of ZnONPs and MSG on the testis at the cellular and oxidative stress levels.

scholarly journals Antioxidant Activities of Green Tea Extract/Zinc Oxide Nanoparticles Against Monosodium Glutamate in Different Organs

2020 ◽  
Vol 8 (1) ◽  
pp. 49-52
Author(s):  
Reham Z. Hamza ◽  
Fawzeh A. Al-Salmi ◽  
Nahla S. El-Shenawy
Keyword(s):  
Zinc Oxide ◽  
Green Tea ◽  
Zinc Oxide Nanoparticles ◽  
Antioxidant Activities ◽  
Monosodium Glutamate ◽  
Toxic Substance ◽  
Green Tea Extract ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Tea Extract

This brief review provided evidence for the role of green tea extract (GTE)/zinc oxide nanoparticles (ZnO NPs) in a variety of biomedical applications against the toxic effect of monosodium glutamate (MSG). MSG is used to enhance the taste, however it causes oxidative stress in the long-term. Many effects of MSG consumption on the brain, obesity, sex organs, and metabolism have been verified. This review covered the effect of GTE/ZnO NPs on many different organs including the liver, kidney, heart, spleen, testis, brain, and pancreas after being exposed to MSG. The review indicated that the toxicity induced by MSG could be restored by GTE/ZnO NPs in different organs. Accordingly, the green nanoparticles could be attended as a futuristic approach to be used against any toxic substance.

Evaluation of the Effect of Nanoparticles Zinc Oxide/Camellia sinensis Complex on the Kidney of Rats Treated with Monosodium Glutamate: Antioxidant and Histological Approaches

2019 ◽  
Vol 20 (7) ◽  
pp. 542-550 ◽  
Author(s):  
Nahla S. El-Shenawy ◽  
Reham Z. Hamza ◽  
Fawziah A. Al-Salmi ◽  
Rasha A. Al-Eisa
Keyword(s):  
Zinc Oxide ◽  
Camellia Sinensis ◽  
Zinc Oxide Nanoparticles ◽  
Morphological Changes ◽  
Monosodium Glutamate ◽  
Oxide Nanoparticles ◽  
High Dose ◽  
Enzymatic Antioxidants ◽  
Zno Nps ◽  
Tea Extract

Background: Zinc oxide nanoparticles (ZnO NPs) are robustly used biomedicine. Moreover, no study has been conducted to explore the consequence of green synthesis of ZnO NPs with Camellia sinensis (green tea extract, GTE) on kidneys of rats treated with monosodium glutamate (MSG). Methods: Therefore, the objective of the research was designed to explore the possible defensive effect of GTE/ZnO NPs against MSG-induced renal stress investigated at redox and histopathological points. Results: The levels of urea and creatinine increased as the effect of a high dose of MSG, in addition, the myeloperoxidase and xanthine oxidase activates were elevated significantly with the high dose of MSG. The levels of non-enzymatic antioxidants (uric acid, glutathione, and thiol) were decreased sharply in MSG-treated rats as compared to the normal group. Conclusion: The data displayed that GTE/ZnO NPs reduced the effects of MSG significantly by reduction of the level peroxidation and enhancement intracellular antioxidant. These biochemical findings were supported by histopathology evaluation, which showed minor morphological changes in the kidneys of rats.

Arctium lappa and management of liver functions to detoxifying the bloodstream

2020 ◽  
Vol 10 ◽  
Author(s):  
Mohaddese Mahboubi
Keyword(s):  
Zinc Oxide ◽  
Carbon Tetrachloride ◽  
Animal Studies ◽  
Main Part ◽  
Liver Enzymes ◽  
Review Article ◽  
Northern Asia ◽  
Arctium Lappa ◽  
Perennial Plant ◽  
Liver Functions

: Arctium lappa or burdock (Compositae family) is a perennial plant, native to Europe, Northern Asia and North America. Burdock roots are known as detoxifying herb to clear toxins from the bloodstream. It seems that its effects are on the liver functions as the main part of body in detoxifying the bloodstream. The aim of this review article was to evaluate the potency of burdock in management of liver functions in detoxifying the bloodstream. The information was extracted from electronic resources (Google scholar, Science Direct, Springer, Magiran). The results of our investigation exhibited that the studies are limited to animal studies, but the results of investigations showed that burdock roots detoxify the liver against ethanol, carbon tetrachloride (CCL4), acetaminophen, cadmium and zinc oxide by improving the functions of liver enzymes. The antioxidant, anti-inflammatory and prebiotic effects of burdock roots may involve in its effects on liver enzymes and detoxifying the blood. The large clinical studies are required to confirm its efficacy on liver functions and detoxify the liver.

Green tea extract outperforms metformin in lipid profile and glycaemic control in overweight women: A double-blind, placebo-controlled, randomized trial

2017 ◽  
Vol 22 ◽  
pp. 1-6 ◽  
Author(s):  
Monallisa Alves Ferreira ◽  
Anna Paula Oliveira Gomes ◽  
Ana Paula Guimarães de Moraes ◽  
Maria Luiza Ferreira Stringhini ◽  
João Felipe Mota ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Randomized Trial ◽  
Lipid Profile ◽  
Green Tea ◽  
Green Tea Extract ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Overweight Women ◽  
Tea Extract

scholarly journals Kidney and Liver Functions and Stress Oxidative Markers of Monosodium Glutamate-Induced Obese Rats

2012 ◽  
Vol 2 (5) ◽  
pp. 168-177 ◽  
Author(s):  
María Del Carmen Contini ◽  
Néstor Millen ◽  
Luisina Riera ◽  
Stella Mahieu
Keyword(s):  
Monosodium Glutamate ◽  
Oxidative Markers ◽  
Obese Rats ◽  
Liver Functions ◽  
Stress Oxidative
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