Brucine Sensitizes HepG2 Human Liver Cancer Cells to 5-fluorouracil via Fas/FasL Apoptotic Pathway

2017 ◽  
Vol 13 (3) ◽  
pp. 323-331
Author(s):  
Guoquan Fan ◽  
Xiaoting Liang ◽  
Yankun He ◽  
Hua Ren ◽  
Jianping Zhao ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Apoptotic Pathway ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

scholarly journals RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Pengfei Sun ◽  
Lei Li ◽  
Zhongchao Li
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Apoptotic Pathway ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Hep3b Cells ◽  
Human Liver Cancer Cells

Background. RAB9, as a member of the Rab GTPase family, is required for the transport of the mannose-6-phosphate receptor (MPR) from late endosomes to trans-Golgi network (TGN). However, the role of RAB9A in tumors, including liver cancer, is still unknown. Methods. We used pcDNA3.1 plasmid to upregulate the expression of RAB9A in Hep3b cells and used specific shRNA to downregulate the expression of RAB9A in HepG2 cells. Biological functions of RAB9A were performed by CCK-8 assay, colony formation assay, apoptosis analysis, transwell assays, and wound healing assays. Finally, an in-depth mechanism study was performed by western blot. Results. RAB9A promoted the proliferation and clonality of Hep3b and HepG2 cells. RAB9A also inhibited apoptosis and the activation of mitochondrial apoptotic pathway. In addition, RAB9A promoted the invasion and migration of Hep3b and HepG2 cells. Importantly, RAB9A activated the AKT/mTOR signaling pathway in human liver cancer cells. A double-effect inhibitor (BEZ235) significantly hindered the effect of RAB9A overexpression on the proliferation and invasion of Hep3b cells. Conclusion. Our data suggest that RAB9A plays a carcinogenic role in human liver cancer progression partially through AKT signaling pathways, suggesting that RAB9A may serve as a potential therapeutic target for liver cancer therapy.

Emodin Regulates Apoptotic Pathway in Human Liver Cancer Cells

2012 ◽  
Vol 27 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Jian-Qing Yu ◽  
Wei Bao ◽  
Jia-Chuan Lei
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Apoptotic Pathway ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

Precise Electrical Detection of Curcumin Cytotoxicity in Human Liver Cancer Cells

2021 ◽  
Author(s):  
Novi Angeline ◽  
Sung-Sik Choo ◽  
Cheol-Hwi Kim ◽  
Suk Ho Bhang ◽  
Tae-Hyung Kim
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Electrical Detection ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

scholarly journals Aberrant miRNA expression response to UV irradiation in human liver cancer cells

2014 ◽  
Vol 9 (3) ◽  
pp. 904-910 ◽  
Author(s):  
GAOFENG LIANG ◽  
GUANGDA LI ◽  
YANYAN WANG ◽  
WANJUN LEI ◽  
ZHONGDANG XIAO
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Uv Irradiation ◽  
Mirna Expression ◽  
Human Liver ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Expression Response ◽  
Human Liver Cancer Cells

scholarly journals Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2β

Hepatology ◽  
2007 ◽  
Vol 47 (2) ◽  
pp. 521-531 ◽  
Author(s):  
Komal Ramani ◽  
Heping Yang ◽  
Meng Xia ◽  
Ainhoa Iglesias Ara ◽  
José M. Mato ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Methionine Adenosyltransferase ◽  
Mitogenic Effect ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells
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