Biochemical and Hormonal Effects of Nymphaea lotus Aqueous Extract on Hyperprolactinemic Female Wistar Rats

2017 ◽  
Vol 12 (3) ◽  
pp. 91-98
Author(s):  
Olubunmi Josephine Sharaibi ◽  
Anthony Jide Afolayan
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Hormonal Effects ◽  
Female Wistar Rats

scholarly journals The Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibits Cell Proliferation Induced by Estradiol on the Uterus and Vagina of Ovariectomized Female Wistar Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Marius Trésor Wego Kamgaing ◽  
Marie Alfrede Mvondo ◽  
Sylviane Laure Poualeu Kamani ◽  
Stéphane Minko Essono ◽  
Sylvie Lea Wansi Ngnokam
Keyword(s):  
Cell Proliferation ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Estradiol Valerate ◽  
Control Groups ◽  
Natural Substances ◽  
Ovx Rats ◽  
Female Wistar Rats ◽  
Potential Alternative ◽  
Dacryodes Edulis

Proliferation is a cellular process strongly linked to the genesis of cancer. Natural substances with antiproliferative activities are currently potential alternatives in the treatment of cancers. Dacryodes edulis, for instance, is a medicinal plant traditionally used in the treatment of cancer. Scientific studies have reported the antioxidant activity of this plant. In addition, the presence of prostate cancer chemopreventive polyphenols was reported in D. edulis extracts. Therefore, this study was aimed to evaluate the effects of the aqueous extract of D. edulis leaves on cell proliferation induced by estradiol in ovariectomized female Wistar rats. In this regard, ovariectomized (OVX) rats were cotreated with estradiol valerate (E2V) (0.75 mg/kg) and the aqueous extract of D. edulis leaves. Control groups received either the vehicle (sham-operated animals and the OVX control), E2V (0.75 mg/kg) only, or E2V (0.75 mg/kg) and tamoxifen (10 mg/kg). Treatments were administered orally for 3 consecutive days, and animals were sacrificed thereafter. Epithelial heights of the uterus and vagina were assessed. Uterine levels of total cholesterol and estradiol were determined as well. Results showed that the aqueous extract of D. edulis leaves reversed the effects of estradiol as it reduced uterine weight ( p < 0.05 ), uterine ( p < 0.05 ), and vaginal ( p < 0.001 ) epithelium heights. This antiproliferative effect of D. edulis was associated with reduced tissue (uterine) levels of estradiol ( p < 0.001 ). These results suggest that the aqueous extract of D. edulis leaves could be a potential alternative treatment for proliferation-related diseases.

scholarly journals Diuretic, Kaliuretic and Anti-Natriuretic Properties of Aqueous Extract of Celosia trigyna L. (Amaranthaceae) on Wistar Rats

2020 ◽  
pp. 37-47
Author(s):  
Touwindséda Aimée Sawadogo ◽  
Youssoufou Ouedrogo ◽  
Lazare Belemnaba ◽  
Filkpièrè Léonard Da ◽  
Balé Bayala
Keyword(s):  
Carbonic Anhydrase ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Negative Control ◽  
Urinary Flow ◽  
Diuretic Effect ◽  
Electrolyte Excretion ◽  
Carbonic Anhydrase Inhibition ◽  
Female Wistar Rats ◽  
Natriuretic Effect

Aims: The purpose of this study was to determine the diuretic and electrolyte excretion properties of the aqueous extract of Celosia trigyna L. (Amaranthaceae) on female Wistar rats. Methodology: The extraction of active principles was done by macerating aerial parts of the plant. The administration of the extract and other products was done by single-dose gavage. Measurements of urinary flow rate (UFR), natriuria, kaliuria and chloruria were taken on urine collected for twenty-four hours after each product was administered. Diuretic activity (DA) and diuretic index (DI), natriuretic and saluretic effects, and carbonic anhydrase inhibition were calculated. A NaCl solution (0.9%) was used as a negative control; furosemide and aldactone were respectively used as hypokalemic and hyperkalemic positive controls. Results: We observed a significant increase in UFR, confirmed by the values of DA and DI, obtained after the administration of extract. For electrolyte excretion, we observed an increase of the kaliuria (p ˂ 0.001) and a decrease of natriuria (p ˂ 0.001) after the extract was administered; chloruria did not significantly changed. We also found a drastic anti-natriuretic dose-dependent effect while saluretic activity and carbonic anhydrase inhibition were not clearly observable. Conclusion: These results confirm the ethnobotanical data about diuretic effect of Celosia trigyna L. extract. This diuretic effect would be supported by a specific increase in K+ excretion suggesting that the extract is possibly hypokalemic. The anti-natriuretic effect suggests that extract possess an aldosterone-like properties.

Abortifacient effect of the aqueous extract of Striga Hermontheca in female wistar rats

2015 ◽  
Vol 104 (3) ◽  
pp. e107
Author(s):  
I.G. Bako ◽  
H.N. Madugu ◽  
A. Adamu ◽  
I.M. Maje
Keyword(s):  
Aqueous Extract ◽  
Wistar Rats ◽  
Female Wistar Rats

scholarly journals ANTI FERTILITY AND ANTI IMPLANTATION EFFECT OF GREEN TEA AQUEOUS EXTRACT ON FEMALE WISTAR RATS

2016 ◽  
Vol 7 (4) ◽  
pp. 106-110
Author(s):  
Nikita Saraswat ◽  
A K Rai ◽  
Ankita Wal ◽  
Khushboo Gaur ◽  
Mohd Faisal ◽  
...  
Keyword(s):  
Green Tea ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Female Wistar Rats

Acute and subacute toxicity of aqueous extract of the tuber of Kedrostis africana (L.) Cogn in Wistar rats

2018 ◽  
Vol 15 (4) ◽  
Author(s):  
Jeremiah Oshiomame Unuofin ◽  
Gloria Aderonke Otunola ◽  
Anthony Jide Afolayan
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Morphological Alteration ◽  
Subchronic Toxicity ◽  
Subacute Toxicity ◽  
Single Oral Administration ◽  
Female Wistar Rats ◽  
Acute Study

Abstract Kedrostis africana (L.) Cogn (Cucurbitaceae) is used in South African traditional medicine and pharmacopoeia as an emetic, purgative and diuretic, and it is used against dropsy in the management of obesity. Aim of the study In this study, acute and subacute toxicity of aqueous extract of K. africanatuber was evaluated in male and female Wistar rats in order to assess its safety profile. Materials and methods In acute toxicity, the effects of a single oral dose (2,000 and 5,000 mg/kg) of aqueous extract was determined in both sexes. General behavior, adverse effects and mortality were determined for 3 h and then periodically for 14 days. The subchronic toxicity test was performed in rats. The effects of the extract in daily single oral administration at the doses of 200, 400 and 600 mg/kg for 28 days were determined. Food and water intakes were monitored daily while body weight was monitored on a weekly bases. Hematological, biochemical and organ parameters were determined at the end of the 28-day administration. Results In the acute study, a single administration of the aqueous extract at the doses of 2,000 and 5,000 mg/kg did not induce mortality. Thus, the LD50 of the aqueous extract of K. africana (AEKA) has been estimated to be higher than 5,000 mg/kg. In the subchronic study, daily oral administration of the AEKA did not result in death of the rats or significant changes in hematological or biochemical parameters at the highest dose of 600 mg/kg. No alteration was observed in body weight, food and water intake. Liver, kidney and heart histopathology did not reveal morphological alteration. Conclusions The results showed that the aqueous tuber extract of K. africana did not cause any death, nor did it cause abnormalities in necropsy and histopathology findings. There were no acute or subchronic toxicity observed, and this indicates that the plant extract could be considered safe for oral medication.

scholarly journals Absence of Renal Protection of an Aqueous Extract of Lemongrass (Cymbopogon citratus) Cultivated in Costa Rica, Using a Model of Acute Renal Failure in Wistar Rats

2019 ◽  
Vol 7 (6) ◽  
pp. 11-19
Author(s):  
Apú Leitón Navilla ◽  
Fallas Ramírez Jose Manuel ◽  
Orozco Aguilar Josué ◽  
Rodríguez Arrieta Jesús Alexander ◽  
Mora Román Juan José
Keyword(s):  
Costa Rica ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Histopathological Analysis ◽  
Sodium Potassium ◽  
Female Wistar Rats ◽  
Nephroprotective Activity ◽  
Layer Chromatography

citratus, known as zacate de limón (lemongrass), is commonly used in Costa Rica for the treatment of "kidney diseases." Therefore, the activity as renal protector of an aqueous extract of this plant was evaluated after oral administration, in a model of acute kidney injury (AKI) in female Wistar rats. For this, an aqueous extract was characterized by thin layer chromatography and qualitative phytochemical tests. An AKI model induced by potassium chromate in female Wistar rats was carried out. The serum concentration of creatinine, sodium, potassium and glucose were determined, as well as the concentrations of creatinine, sodium, potassium, glucose and proteins in urine, together with the urinary flow determination. A histopathological analysis of the subjects’ kidneys was performed, and the presence of kidney damage was identified. The characterization of the extract by thin layer chromatography, and ferric chloride, Shinoda and Wilson tests gave negative results for phenols, tannins and flavonoids. No positive changes were observed in renal function markers in urine. No histopathological evidence of nephroprotective activity of the aqueous extract of C. citratus was found. It is concluded that the aqueous extract of C. citratus obtained by infusion does not possess nephroprotective activity at a dose of 150 mg/kg evaluated by the AKI in female Wistar rats.

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